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Mouse IL-33 Antibody

Catalog #: AF3626
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AF3626
AF3626-SP
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Detection of Mouse IL‑33 by Western Blot.
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Citations (143)
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Mouse IL-33 Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse IL-33 in ELISAs and Western blots. In sandwich immunoassays, less than 2% cross-reactivity with recombinant human IL‑33 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant mouse IL-33
Ser109-Ile266
Accession # Q8BVZ5
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.4 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Immunocytochemistry
5-15 µg/mL
See below
Intracellular Staining by Flow Cytometry
2.5 µg/106 cells
See below

Mouse IL-33 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
0.2-0.8 µg/mL 

Use in combination with:

Detection Reagent: Mouse IL‑33 Biotinylated Antibody (Catalog # BAF3626)

Standard: Recombinant Mouse IL-33 Protein (Catalog # 3626-ML)

Neutralization
Measured by its ability to neutralize IL‑33-induced proliferation in the D10.G4.1 mouse helper T cell line. Schmitz, J. et al. (2005) Immunity 23:479. The Neutralization Dose (ND50) is typically 10-50 ng/mL in the presence of 0.25 ng/mL Recombinant Mouse IL‑33.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Mouse IL-33 antibody by Western Blot. View Larger

Detection of Mouse IL‑33 by Western Blot. Western blot shows lysates of HEK293T human embryonic kidney cell line either mock transfected or transfected with full length mouse IL-33. PVDF membrane was probed with 0.4 µg/mL of Goat Anti-Mouse IL-33 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3626) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for IL-33 at approximately 37 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunohistochemistry IL-33 antibody in Mouse Spleen by Immunohistochemistry (IHC-Fr). View Larger

IL‑33 in Mouse Spleen. IL-33 was detected in immersion fixed frozen sections of mouse spleen using Goat Anti-Mouse IL-33 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3626) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in lymphocytes. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Immunocytochemistry IL-33 antibody in bEnd by Immunocytochemistry (ICC).3 Mouse Cell Line by Immunocytochemistry (ICC). View Larger

IL‑33 in bEnd.3 Mouse Cell Line. IL-33 was detected in immersion fixed bEnd.3 mouse endothelioma cell line using Goat Anti-Mouse IL-33 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3626) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; Catalog # NL001) and counterstained with DAPI (blue, lower panel). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Intracellular Staining by Flow Cytometry Detection of IL-33 antibody in Mouse Splenocytes antibody by Flow Cytometry. View Larger

Detection of IL‑33 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were treated for 5 hours with 50 ng/mL PMA and 1 µg/mL Ca2+ionomycin then stained with Goat Anti-Mouse IL-33 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3626, filled histogram) or isotype control antibody (Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.

Neutralization Proliferation Induced by IL‑33 and Neutralization by Human IL‑33 Antibody. View Larger

Proliferation Induced by IL‑33 and Neutralization by Human IL‑33 Antibody. Recombinant Mouse IL-33 (Catalog # 3626-ML) stimulates proliferation in the D10.G4.1 mouse helper T cell line in a dose-dependent manner (orange line), as measured by Resazurin (Catalog # AR002). Proliferation elicited by Recombinant Mouse IL-33 (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse IL-33 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3626). The ND50 is typically 10-50 ng/mL.

Immunohistochemistry Detection of Mouse IL-33 by Immunohistochemistry View Larger

Detection of Mouse IL-33 by Immunohistochemistry IL-33/ST2 axis in tendon healing in vivo.Kinetics of (a) Il33 and (b) soluble St2 gene expression post injury. Data are mean fold change±s.d. showing relative expression to 18s housekeeping gene (pooled data from four mice per group performed on four sequential occasions, n=16 per condition). *P<0.05, **P<0.01 versus control (WT) mice (ANOVA) +P<0.05,++P<0.01, NS not significant; control (WT) injured versus St2−/− injured. (c) Immunohistochemistry showing IL-33 and ST2 expression in tendon biopsies of WT and St2−/− mice day 1 post injury. IgG control shown in bottom left of pictures. Black horizontal line indicates 50 μm. (d) Col3 mRNA and (e) Collagen 3 protein levels in tendon biopsies of WT and St2−/− mice post injury. (f) Col1 mRNA and (g) Collagen 1 protein levels in tendon biopsies of WT and St2−/− mice post injury. For (d–g) data are mean±s.d. of duplicate samples, representative of four mice per condition (n=16). *P<0.05, **P<0.01 versus control (WT) mice. +P<0.05, ++P<0.01 control (WT) injured versus St2−/− injured mice (ANOVA). mRNA graphs show relative expression to 18s housekeeping gene. (h) Percentage change in tendon strength for WT and St2−/− mice post injury. Data are mean±s.d., representative of four mice per condition (n=16). *P<0.05, **P<0.01 versus control mice. #P<0.05 St2−/− injured versus WT injured mice (Mann–Whitney U-test). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25857925), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Mouse IL-33 by Western Blot View Larger

Detection of Mouse IL-33 by Western Blot HMGB1 increases IL-33 expression and acts as an autocrine factor in enhancing IL-33 expression in a partial TLR-4 dependent fashion during cyclic stretch.(A) MLE-12 cells were treated with 3 μg/ml HMGB1 or control solution before 6h cyclic stretch and IL-33 production was measured by ELISA. (B) MLE-12 cells were treated with 10 μg/ml HMGB1 neutralizing antibody (2G7) or control solution before 6h cyclic stretch and IL-33 production was detected by Western blot. beta -actin served as loading control. (C) MLE-12 cells transfecting with non-specific control siRNA or TLR-4-specific siRNA were treated with 3 μg/ml HMGB1 or control solution before stretch. IL-33 production in each group was measured with ELISA. **P<0.01, ***P<0.001 when compared between groups denoted by horizontal lines. Each stretching group collected at least from three wells and represented a single experiment, the bar graphs illustrate data representative of three independent experiments. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/28898270), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Human IL-33 by Immunohistochemistry View Larger

Detection of Human IL-33 by Immunohistochemistry IL-33/ST2 expression in human tendon.(a) IL-33, (b) soluble ST2 (sST2) and (c) mST2 mRNA expression in human tendon samples. Fold change in gene expression of IL-33, sST2 and mST2 in control (semi-membranosus tendon, n=10), torn supraspinatus tendon (established pathology) and matched subscapularis human tendon samples (early pathology; n=17). Data are mean±s.d. relative to the housekeeping gene18S (mean of duplicate analysis). *P<0.05, **P<0.01, ***P<0.001 versus control (Student's t-test). (d) Immunostaining of IL-33 and ST2 in control (n=10), torn tendon (n=17) and early tendinopathy (n=17). Graphs illustrate modified Bonar scoring based on 10 high-power fields. Data are mean±s.d. *P<0.05, **P<0.01 versus control (Student's t-test). Scale bar, 65 μm. (e) Fold change in gene expression of IL33 and ST2 24 h post incubation with tumour necrosis factor (TNF-alpha ), IL-1 beta or in combination depicting relative expression to media alone utilizing housekeeping gene GAPDH. Data are mean±s.d. of triplicate samples, representative of three individual patient samples. *P<0.05, **P<0.01 versus control (media) (Student's t-test). (f) IL-33 immunostaining of human tendon explants cultured for 24 h with medium (control), 100 ng ml−1 TNF alpha or 100 ng ml−1 TNF alpha +100 ng ml−1 IL-1 beta. (g) Fold change in COL1 and COL3 mRNA expression in human tendon explants cultured for 24 h with rhIL-33, relative to housekeeping gene GAPDH. (h) Time course of COL1 and COL3 mRNA expression following incubation with rhIL-33, relative to housekeeping gene GAPDH. (i) Collagen 1 and 3 protein expression in human tendon explants 24 h post incubation with rhIL-33. For (g–i) data are mean±s.d. of triplicate samples, representative of three individual patients. *P<0.05, **P<0.01 versus control (Student's t-test). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25857925), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse Mouse IL-33 Antibody by Immunohistochemistry View Larger

Detection of Mouse Mouse IL-33 Antibody by Immunohistochemistry Prior Nb exposure results in earlier and exacerbated HSV-2 pathology. (I and J) (I) Vaginal IL-33 measured by ELISA (day 2) and (J) IF staining of vaginal tissue (day 3; n = 4). Data are representative of two independent experiments with 4–6 mice per group (mean ± SEM). Statistical significance was calculated by two-way analysis of variance (ANOVA) with Bonferroni correction for multiple comparisons and Mann-Whitney t test. ∗p ≤ 0.05, ∗∗p ≤ 0.01, ∗∗p ≤ 0.01, ∗∗∗p ≤ 0.001, ns, not significant. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33857419), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-33

IL-33, also known as NF-HEV and DVS 27, is a 30 kDa proinflammatory protein that may also regulate gene transcription (1-3). DVS 27 was identifed as a gene that is upregulated in vasospastic cerebral arteries (1). NF-HEV was described as a nuclear factor that is preferentially expressed in the endothelial cells of high endothelial venules relative to endothelial cells from other tissues (2). IL-33 was identified based on sequence and structural homology with IL-1 family cytokines (3). DVS 27, NF-HEV, and IL-33 share 100% amino acid sequence identity. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL-1 beta stimulation (1, 3). Similar to IL-1, IL-33 can be cleaved in vitro by caspase-1, generating an N-terminal fragment that is slightly shorter than the C-terminal fragment (3, 4). The N-terminal portion of full length IL-33 contains a predicted bipartite nuclear localization sequence and a homeodomain-like helix-turn-helix DNA binding domain. By immunofluorescence, full length IL-33 localizes to the nucleus in HUVECs and transfectants (2). The C-terminal fragment, corresponding to mature IL-33, binds and triggers signaling through mast cell IL-1 R4/ST2L, a longtime orphan receptor involved in the augmentation of Th2 cell responses (3, 5-7). A ternary signaling complex is formed by the subsequent association of IL-33 and ST2L with IL-1R AcP (8). Stimulation of Th2 polarized lymphocytes with mature IL-33 in vitro induces IL-5 and IL-13 secretion (3). In vivo administration of mature IL-33 promotes increased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues (3). Full length and mature mouse IL-33 share approximately 55% and 90% aa sequence identity with human and rat IL-33, respectively. Mouse IL-33 shares less than 25% aa sequence identity with other IL-1 family proteins.

References
  1. Onda, H. et al. (1999) J. Cereb. Blood Flow Metab. 19:1279.
  2. Baekkevold, E.S. et al. (2003) Am. J. Pathol. 163:69.
  3. Schmitz, J. et al. (2005) Immunity 23:479.
  4. Black, R.A. et al. (1989) J. Biol. Chem. 264:5323.
  5. Xu, D. et al. (1998) J. Exp. Med. 187:787.
  6. Lohning, M. et al. (1998) Proc. Natl. Acad. Sci. USA 95:6930.
  7. Dinarello, C.A. (2005) Immunity 23:461.
  8. Chackerian, A.A. et al. (2007) J. Immunol. 179:2551.
Long Name
Interleukin 33
Entrez Gene IDs
90865 (Human); 77125 (Mouse)
Alternate Names
C9orf26; C9orf26chromosome 9 open reading frame 26 (NF-HEV); DKFZp586H0523; DVS27; DVS27-related protein; IL1F11; IL-1F11; IL33; IL-33; interleukin 33; Interleukin-1 family member 11; interleukin-33; NFHEV; NF-HEV; NF-HEVNFEHEV; Nuclear factor from high endothelial venules; RP11-575C20.2

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Citations for Mouse IL-33 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

143 Citations: Showing 1 - 10
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  1. IL-33/ST2 signaling in monocyte-derived macrophages maintains blood-brain barrier integrity and restricts infarctions early after ischemic stroke
    Authors: Wang, M;Dufort, C;Du, Z;Shi, R;Xu, F;Huang, Z;Sigler, AR;Leak, RK;Hu, X;
    Journal of neuroinflammation
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  2. Oligodendroglial fatty acid metabolism as a central nervous system energy reserve
    Authors: Asadollahi, E;Trevisiol, A;Saab, AS;Looser, ZJ;Dibaj, P;Ebrahimi, R;Kusch, K;Ruhwedel, T;Möbius, W;Jahn, O;Lee, JY;Don, AS;Khalil, MA;Hiller, K;Baes, M;Weber, B;Abel, ED;Ballabio, A;Popko, B;Kassmann, CM;Ehrenreich, H;Hirrlinger, J;Nave, KA;
    Nature neuroscience
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  3. A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy
    Authors: Bisen, S;Verma, SK;Mukhopadhyay, CS;Singh, NK;
    Experimental & molecular medicine
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  4. Active secretion of IL-33 from astrocytes is dependent on TMED10 and promotes central nervous system homeostasis
    Authors: Jiao, M;Wang, C;Tang, X;Dai, C;Zhang, N;Fan, A;Qian, Z;Liu, S;Zhang, F;Li, B;Xu, Y;Tan, Z;Gong, F;Lu, Y;Zheng, F;
    Brain, behavior, and immunity
    Species: Mouse, Transgenic Mouse
    Sample Types: Cell Lysates, Tissue Homogenates, Whole Cells
    Applications: Western Blot, Neutralization
  5. Glyceryl triacetate promotes blood-brain barrier recovery after ischemic stroke through lipogenesis-mediated IL-33 in mice
    Authors: Wei, H;Zhen, L;Wang, S;Yang, L;Zhang, S;Zhang, Y;Jia, P;Wang, T;Wang, K;Zhang, Y;Ma, L;Lv, J;Zhang, P;
    Journal of neuroinflammation
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  6. CEBPA restricts alveolar type 2 cell plasticity during development and injury-repair
    Authors: Hassan, D;Chen, J;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  7. PTRF-IL33-ZBP1 signaling mediating macrophage necroptosis contributes to HDM-induced airway inflammation
    Authors: Du, J;Liu, Y;Lan, G;Zhou, Y;Ni, Y;Liao, K;Zheng, F;Cheng, Q;Shi, G;Su, X;
    Cell death & disease
    Species: Mouse
    Sample Types: Cell Lysates, Tissue Homogenates
    Applications: Western Blot
  8. Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization
    Authors: Geetika Kaur, Deepti Sharma, Shivantika Bisen, Chandra Sekhar Mukhopadhyay, Katherine Gurdziel, Nikhlesh K. Singh
    Communications Biology
  9. Fungal mycobiome-mediated immune response: a non-negligible promoter in pancreatic oncogenesis and chemoresistance
    Authors: Yaling Jiang, Valentina Donati, Godefridus J. Peters, Elisa Giovannetti, Dong Mei Deng
    Cancer Drug Resistance
  10. TMEM59 ablation leads to loss of olfactory sensory neurons and impairs olfactory functions via interaction with inflammation
    Authors: Z Ma, W Li, L Zhuang, T Wen, P Wang, H Yu, Y Liu, Y Yu
    Brain, Behavior, and Immunity, 2023-04-13;111(0):151-168.
    Species: Moyse
    Sample Types: Whole Tissue
    Applications: IHC
  11. Exogenous interleukin 33 enhances the brain's lymphatic drainage and toxic protein clearance in acute traumatic brain injury mice
    Authors: M Liu, J Huang, T Liu, J Yuan, C Lv, Z Sha, C Wu, W Jiang, X Liu, M Nie, Y Chen, S Dong, Y Qian, C Gao, Y Fan, D Wu, R Jiang
    Acta neuropathologica communications, 2023-04-07;11(1):61.
    Species: Mouse
    Sample Types:
    Applications: In Vivo
  12. Age-dependent Pdgfrbeta signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice
    Authors: AM Benvie, D Lee, BM Steiner, S Xue, Y Jiang, DC Berry
    Nature Communications, 2023-03-31;14(1):1806.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  13. Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination
    Authors: J Hou, Y Zhou, Z Cai, M Terekhova, A Swain, PS Andhey, RM Guimaraes, A Ulezko Ant, T Qiu, S Sviben, G Strout, JAJ Fitzpatric, Y Chen, S Gilfillan, DH Kim, SJ Van Dyken, MN Artyomov, M Colonna
    Cell Reports, 2023-03-21;42(4):112293.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  14. IL-33-mediated activation of mast cells is involved in the progression of imiquimod-induced psoriasis-like dermatitis
    Authors: Xuyue Zhou, Yu Hu, Lingxi Liu, Lihao Liu, Hongying Chen, Dan Huang et al.
    Cell Communication and Signaling
  15. Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice
    Authors: Cheong LY, Wang B, Wang Q et al.
    Nature communications
  16. Active eosinophils regulate host defence and immune responses in colitis
    Authors: Alessandra Gurtner, Costanza Borrelli, Ignacio Gonzalez-Perez, Karsten Bach, Ilhan E. Acar, Nicolás G. Núñez et al.
    Nature
  17. Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice
    Authors: Zhao J, Jung S, Li X et al.
    Journal of Clinical Investigation
  18. Restoring myocardial infarction-induced long-term memory impairment by targeting the cystic fibrosis transmembrane regulator
    Authors: Lotte Vanherle, Darcy Lidington, Franziska E. Uhl, Saskia Steiner, Stefania Vassallo, Cecilia Skoug et al.
    eBioMedicine
  19. IL-33/ST2 axis promotes remodeling of the extracellular matrix and drives protective microglial responses in the mouse model of perioperative neurocognitive disorders
    Authors: S Li, H Liu, Y Qian, L Jiang, S Liu, Y Liu, C Liu, X Gu
    International immunopharmacology, 2022-11-26;114(0):109479.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  20. Targeting TNF-alpha producing macrophages activate antitumor immunity in pancreatic cancer through IL33 signaling
    Authors: Ajay Dixit, Aaron L Sarver, Jon Zettervall, Huocong Huang, Kexin Zheng, Rolf A. Brekken et al.
    JCI Insight
  21. IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection
    Authors: L Xu, C Wei, Y Chen, Y Wu, X Shou, W Chen, D Lu, H Sun, W Li, B Yu, X Wang, X Zhang, Y Yu, Z Lei, R Tang, J Zhu, Y Li, L Lu, H Zhou, S Zhou, C Su, X Chen
    Nature Communications, 2022-11-12;13(1):6881.
    Species: Mouse
    Sample Types: In Vivo, Tissue Homogenates
    Applications: Neutralization, Western Blot
  22. Organoids capture tissue-specific innate lymphoid cell development in mice and humans
    Authors: GM Jowett, E Read, LB Roberts, D Coman, M Vilà Gonzá, T Zabinski, U Niazi, R Reis, TJ Trieu, D Danovi, E Gentleman, L Vallier, MA Curtis, GM Lord, JF Neves
    Cell Reports, 2022-08-30;40(9):111281.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  23. In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response
    Authors: J Glaubitz, A Wilden, J Golchert, G Homuth, U Völker, BM Bröker, T Thiele, MM Lerch, J Mayerle, AA Aghdassi, FU Weiss, M Sendler
    Nature Communications, 2022-08-03;13(1):4502.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  24. Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A2BAR signaling in intestinal epithelial cells
    Authors: Darine W. El-Naccache, Fei Chen, Mark J. Palma, Alexander Lemenze, Matthew A. Fischer, Wenhui Wu et al.
    Cell Reports
  25. Short-term high fat feeding induces inflammatory responses of tuft cells and mucosal barrier cells in the murine stomach
    Authors: P Widmayer, P Pregitzer, H Breer
    Histology and histopathology, 2022-07-29;0(0):18503.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  26. IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy
    Authors: Deepti Sharma, Shivantika Bisen, Geetika Kaur, Eric C. Van Buren, Gadiparthi N. Rao, Nikhlesh K. Singh
    Communications Biology
  27. Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche
    Authors: K Kos, MA Aslam, R van de Ven, MD Wellenstei, W Pieters, A van Weverw, DEM Duits, K van Pul, CS Hau, K Vrijland, D Kaldenbach, EAM Raeven, SA Quezada, R Beyaert, H Jacobs, TD de Gruijl, KE de Visser
    Cell Reports, 2022-03-01;38(9):110447.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  28. Therapeutic Potential of a Combination of Electroacupuncture and Human iPSC-Derived Small Extracellular Vesicles for Ischemic Stroke
    Authors: P Deng, L Wang, Q Zhang, S Chen, Y Zhang, H Xu, H Chen, Y Xu, W He, J Zhang, H Sun
    Cells, 2022-02-26;11(5):.
    Species: Mouse
    Sample Types: Tissue Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  29. Roxadustat (FG-4592) Facilitates Recovery From Renal Damage by Ameliorating Mitochondrial Dysfunction Induced by Folic Acid
    Authors: Xue Li, Bo Jiang, Yu Zou, Jie Zhang, Yuan-Yuan Fu, Xiao-Yue Zhai
    Frontiers in Pharmacology
  30. Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
    Authors: Aftab Alam, Eric Levanduski, Parker Denz, Helena Solleiro Villavicencio, Maulasri Bhatta, Lamees Alhorebi et al.
    Cancer Cell
  31. Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
    Authors: Danyang He, Heping Xu, Huiyuan Zhang, Ruihan Tang, Yangning Lan, Ruxiao Xing et al.
    Immunity
  32. Interleukin-33 activates group 2 innate lymphoid cell expansion and modulates endometriosis
    Authors: JE Miller, H Lingegowda, LK Symons, O Bougie, SL Young, BA Lessey, M Koti, C Tayade
    JCI Insight, 2021-12-08;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  33. Eosinophil extracellular traps drive asthma progression through neuro-immune signals
    Authors: Y Lu, Y Huang, J Li, J Huang, L Zhang, J Feng, J Li, Q Xia, Q Zhao, L Huang, S Jiang, S Su
    Nature Cell Biology, 2021-10-06;23(10):1060-1072.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  34. The impact of airborne endotoxin exposure on rheumatoid arthritis-related joint damage, autoantigen expression, autoimmunity, and lung disease
    Authors: TR Mikuls, R Gaurav, GM Thiele, BR England, MG Wolfe, BP Shaw, KL Bailey, TA Wyatt, AJ Nelson, MJ Duryee, CD Hunter, D Wang, DJ Romberger, DP Ascherman, JA Poole
    International immunopharmacology, 2021-08-27;100(0):108069.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  35. IL-33 promotes innate lymphoid cell-dependent IFN-gamma production required for innate immunity to Toxoplasma gondii
    Authors: Joseph T Clark, David A Christian, Jodi A Gullicksrud, Joseph A Perry, Jeongho Park, Maxime Jacquet et al.
    eLife
  36. Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection
    Authors: Alisha Chetty, Matthew G. Darby, Pia M. Vornewald, Mara Martín-Alonso, Anna Filz, Manuel Ritter et al.
    Cell Host & Microbe
  37. A gene-environment-induced epigenetic program initiates tumorigenesis
    Authors: D Alonso-Cur, YJ Ho, C Burdziak, JLV Maag, JP Morris, R Chandwani, HA Chen, KM Tsanov, FM Barriga, W Luan, N Tasdemir, G Livshits, E Azizi, J Chun, JE Wilkinson, L Mazutis, SD Leach, R Koche, D Pe'er, SW Lowe
    Nature, 2021-02-03;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  38. ROR alpha is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
    Authors: Ana C. F. Ferreira, Aydan C. H. Szeto, Morgan W. D. Heycock, Paula A. Clark, Jennifer A. Walker, Alastair Crisp et al.
    Nature Immunology
  39. Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
    Authors: NB Leimkühler, HFE Gleitz, L Ronghui, IAM Snoeren, SNR Fuchs, JS Nagai, B Banjanin, KH Lam, T Vogl, C Kuppe, USA Stalmann, G Büsche, H Kreipe, I Gütgemann, P Krebs, Y Banz, P Boor, EW Tai, TH Brümmendor, S Koschmiede, M Crysandt, E Bindels, R Kramann, IG Costa, RK Schneider
    Cell Stem Cell, 2020-12-09;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. Fibroblast-derived IL-33 facilitates breast cancer metastasis by modifying the immune microenvironment and driving type-2 immunity
    Authors: Ophir Shani, Tatiana Vorobyov, Lea Monteran, Dor Lavie, Noam Cohen, Yael Raz et al.
    Cancer Research
  41. IL-33 Mediates Lung Inflammation by the IL-6-Type Cytokine Oncostatin M
    Authors: F Botelho, A Dubey, EA Ayaub, R Park, A Yip, A Humbles, R Kolbeck, CD Richards
    Mediators of Inflammation, 2020-11-28;2020(0):4087315.
    Species: Mouse
    Sample Types: Tissue Lysates
    Applications: Western Blot
  42. Tumor-derived interleukin-33 promotes tissue-resident CD8+ T cells and is required for checkpoint blockade tumor immunotherapy
    Authors: Lujun Chen, Runzi Sun, Junchi Xu, Wensi Zhai, Dachuan Zhang, Min Yang et al.
    Cancer Immunology Research
  43. Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling
    Authors: Katherine M. Still, Samantha J. Batista, Carleigh A. O’Brien, Oyebola O. Oyesola, Simon P. Früh, Lauren M. Webb et al.
    PLOS Pathogens
  44. IL-33 Alarmin and Its Active Proinflammatory Fragments Are Released in Small Intestine in Celiac Disease
    Authors: Federico Perez, Carolina N. Ruera, Emanuel Miculan, Paula Carasi, Karen Dubois-Camacho, Laura Garbi et al.
    Frontiers in Immunology
  45. Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk
    Authors: J Huang, MA Gandini, L Chen, S M'Dahoma, PL Stemkowski, H Chung, DA Muruve, GW Zamponi
    Cell Rep, 2020-10-06;33(1):108233.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  46. Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection
    Authors: T Li, Z Zhang, JG Bartolacci, GK Dwyer, Q Liu, L Mathews, M Velayutham, A Roessing, YC Lee, H Dai, S Shiva, MH Oberbarnsc, JL Dziki, SJ Mullett, SG Wendell, JD Wilkinson, SA Webber, MA Wood-Trage, SC Watkins, AJ Demetris, GS Hussey, SF Badylak, HR Turnquist
    J. Clin. Invest., 2020-10-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  47. Anacardic acid induces IL-33 and promotes remyelination in CNS
    Authors: Åsa Ljunggren-Rose, Chandramohan Natarajan, Pranathi Matta, Akansha Pandey, Isha Upender, Subramaniam Sriram
    Proceedings of the National Academy of Sciences
  48. Fibroblast-derived IL-33 is dispensable for lymph node homeostasis but critical for CD8 T cell responses to acute and chronic viral infection
    Authors: P Aparicio-D, H Cannelle, MB Buechler, S Nguyen, SM Kallert, S Favre, N Alouche, N Papazian, B Ludewig, T Cupedo, DD Pinschewer, SJ Turley, SA Luther
    Eur. J. Immunol., 2020-08-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC
  49. Group 2 Innate Lymphoid Cells Must Partner with the Myeloid-Macrophage Lineage for Long-Term Postviral Lung Disease
    Authors: K Wu, X Wang, SP Keeler, BJ Gerovac, EV Agapov, DE Byers, S Gilfillan, M Colonna, Y Zhang, MJ Holtzman
    J. Immunol., 2020-07-08;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Supernates, Whole Cells
    Applications: ICC, Western Blot
  50. Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
    Authors: Phi T. Nguyen, Leah C. Dorman, Simon Pan, Ilia D. Vainchtein, Rafael T. Han, Hiromi Nakao-Inoue et al.
    Cell
  51. A Truncated Form of HpARI Stabilizes IL-33, Amplifying Responses to the Cytokine
    Authors: Caroline Chauché, Francesco Vacca, Shin Li Chia, Josh Richards, William F. Gregory, Adefunke Ogunkanbi et al.
    Frontiers in Immunology
  52. IL-33/ST2 axis is involved in disease progression in the spleen during Leishmania donovani infection
    Authors: A Lamberet, O Rostan, S Dion, A Jan, H Guegan, C Manuel, M Samson, JP Gangneux, F Robert-Gan
    Parasit Vectors, 2020-06-22;13(1):320.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  53. PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy
    Authors: Andrea Farini, Chiara Villa, Dario Di Silvestre, Pamela Bella, Luana Tripodi, Rossana Rossi et al.
    Frontiers in Physiology
  54. Interleukin-33 Signaling Controls the Development of Iron-Recycling Macrophages
    Authors: Yuning Lu, Gemma Basatemur, Ian C. Scott, Davide Chiarugi, Marc Clement, James Harrison et al.
    Immunity
  55. Strain-Specific Differences in House Dust Mite (Dermatophagoides farinae)-Induced Mouse Models of Allergic Rhinitis
    Authors: KI Lee, JS Bae, EH Kim, JH Kim, L Lyu, YJ Chung, JH Mo
    Clin Exp Otorhinolaryngol, 2020-05-15;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  56. Myristoylation of LMCD1 Leads to Its Species-Specific Derepression of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression During Development of Vascular Lesions
    Authors: Suresh Govatati, Prahalathan Pichavaram, Jagadeesh Janjanam, Liang Guo, Renu Virmani, Gadiparthi N. Rao
    Arteriosclerosis, Thrombosis, and Vascular Biology
  57. Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model
    Authors: K Takenaga, M Akimoto, N Koshikawa, H Nagase
    PLoS ONE, 2020-04-27;15(4):e0232230.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  58. Dynamic Expression of Interleukin-33 and ST2 in the Mouse Reproductive Tract Is Influenced by Superovulation
    Authors: Salma Begum, Barry E. Perlman, Nuriban Valero-Pacheco, Valerie O’Besso, Tracy Wu, Sara S. Morelli et al.
    Journal of Histochemistry & Cytochemistry
  59. Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity
    Authors: Anne-Laure Flamar, Christoph S.N. Klose, Jesper B. Moeller, Tanel Mahlakõiv, Nicholas J. Bessman, Wen Zhang et al.
    Immunity
  60. ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
    Authors: JA Moral, J Leung, LA Rojas, J Ruan, J Zhao, Z Sethna, A Ramnarain, B Gasmi, M Gururajan, D Redmond, G Askan, U Bhanot, E Elyada, Y Park, DA Tuveson, M Gönen, SD Leach, JD Wolchok, RP DeMatteo, T Merghoub, VP Balachandr
    Nature, 2020-02-19;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IF, IHC
  61. Effective Nephroprotection Against Acute Kidney Injury with a Star-Shaped Polyglutamate-Curcuminoid Conjugate
    Authors: G Córdoba-Da, A Duro-Casta, RC Castelo-Br, C González-G, P Cannata, AB Sanz, MJ Vicent, A Ortiz, AM Ramos
    Sci Rep, 2020-02-06;10(1):2056.
    Species: Mouse
    Sample Types: Cell Culture Lysates
    Applications: Western Blot
  62. IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
    Authors: J Augustine, S Pavlou, I Ali, K Harkin, E Ozaki, M Campbell, AW Stitt, H Xu, M Chen
    J Neuroinflammation, 2019-12-03;16(1):251.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  63. Chronic exposure to high fat diet triggers myelin disruption and interleukin-33 upregulation in hypothalamus
    Authors: Hui-Ting Huang, Sheng-Feng Tsai, Hung-Tsung Wu, Hsin-Ying Huang, Han-Hsueh Hsieh, Yu-Ming Kuo et al.
    BMC Neuroscience
  64. Early Life Represents a Vulnerable Time Window for IL-33–Induced Peripheral Lung Pathology
    Authors: Li Y. Drake, Diane Squillace, Koji Iijima, Takao Kobayashi, Masaru Uchida, Gail M. Kephart et al.
    The Journal of Immunology
  65. Single-cell transcriptomic profiling of the aging mouse brain
    Authors: Methodios Ximerakis, Scott L. Lipnick, Brendan T. Innes, Sean K. Simmons, Xian Adiconis, Danielle Dionne et al.
    Nature Neuroscience
  66. A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue
    Authors: Batika M.J. Rana, Eric Jou, Jillian L. Barlow, Noe Rodriguez-Rodriguez, Jennifer A. Walker, Claire Knox et al.
    Journal of Experimental Medicine
  67. Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma
    Authors: Eryi Wang, Xiaoyu Liu, Wei Tu, Danh C. Do, Haiqiong Yu, Liteng Yang et al.
    Allergy
  68. IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization
    Authors: MF Eissmann, C Dijkstra, A Jarnicki, T Phesse, J Brunnberg, AR Poh, N Etemadi, E Tsantikos, S Thiem, ND Huntington, ML Hibbs, A Boussiouta, MA Grimbaldes, M Buchert, RJJ O'Donoghue, F Masson, M Ernst
    Nat Commun, 2019-06-21;10(1):2735.
    Species: Mouse, Transgenic Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC, Western Blot
  69. Interleukin‑33 promotes obstructive renal injury via macrophages
    Authors: Yanlei Li, Jing Liu, Ting Yu, Bingdi Yan, Hongjun Li
    Molecular Medicine Reports
  70. NFATc1-E2F1-LMCD1–Mediated IL-33 Expression by Thrombin Is Required for Injury-Induced Neointima Formation
    Authors: Suresh Govatati, Prahalathan Pichavaram, Jagadeesh Janjanam, Baolin Zhang, Nikhlesh K. Singh, Arul M. Mani et al.
    Arteriosclerosis, Thrombosis, and Vascular Biology
  71. Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection
    Authors: A Zychlinsky, M Rousseau, L Lacerda Ma, T Canton, CR Consiglio, ML Albert, M Fontes, D Duffy, MA Ingersoll
    JCI Insight, 2019-05-30;5(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  72. Matrix bound nanovesicle-associated IL-33 activates a pro-remodeling macrophage phenotype via a non-canonical, ST2-independent pathway
    Authors: GS Hussey, JL Dziki, YC Lee, JG Bartolacci, M Behun, HR Turnquist, SF Badylak
    J Immunol Regen Med, 2019-02-01;3(0):26-35.
    Species: Mouse
    Sample Types: Matrix Bound Nanovesicles
    Applications: Western Blot
  73. IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages
    Authors: EO Weinberg, B Ferran, Y Tsukahara, MMS Hatch, J Han, CE Murdoch, R Matsui
    PLoS ONE, 2019-01-25;14(1):e0210827.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  74. RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development
    Authors: H Anderton, E Bandala-Sa, DS Simpson, JA Rickard, AP Ng, L Di Rago, C Hall, JE Vince, J Silke, G Liccardi, R Feltham
    Cell Death Differ., 2018-09-05;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  75. Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species
    Authors: Danny Ben-Zvi, Luca Meoli, Wasif M. Abidi, Eirini Nestoridi, Courtney Panciotti, Erick Castillo et al.
    Cell Metabolism
  76. TCR transgenic mice reveal step-wise, multi-site acquisition of the distinctive fat-Treg phenotype
    Authors: Chaoran Li, Joanna R. DiSpirito, David Zemmour, Raul German Spallanzani, Wilson Kuswanto, Christophe Benoist et al.
    Cell
  77. Phenotyping acute and chronic atopic dermatitis-like lesions in Stat6VT mice identifies a role for IL-33 in disease pathogenesis
    Authors: Sonia C. DaSilva-Arnold, Anita Thyagarajan, Leroy J. Seymour, Qiaofang Yi, Joshua R. Bradish, Mohammed Al-Hassani et al.
    Archives of Dermatological Research
  78. Endogenous IL-33 Contributes to Kidney Ischemia-Reperfusion Injury as an Alarmin
    Authors: Maroua Ferhat, Aurélie Robin, Sébastien Giraud, Sandra Sena, Jean-Michel Goujon, Guy Touchard et al.
    Journal of the American Society of Nephrology
  79. IL-1? mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation
    Authors: I Mahmutovic, M Menzel, S Ramu, S Cerps, H Akbarshahi, L Uller
    Respir. Res., 2018-01-24;19(1):16.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  80. Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity
    Authors: T Liu, NA Barrett, Y Kanaoka, E Yoshimoto, D Garofalo, H Cirka, C Feng, JA Boyce
    J. Immunol., 2017-12-27;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  81. Behavioral Changes in Mice Lacking Interleukin-33
    Authors: E Dohi, EY Choi, IVL Rose, AS Murata, S Chow, M Niwa, SI Kano
    eNeuro, 2017-12-26;4(6):.
    Species: Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: IHC-Fr, Western Blot
  82. Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms
    Authors: M Yamaguchi, SK Samuchiwal, O Quehenberg, JA Boyce, B Balestrier
    Mucosal Immunol, 2017-12-20;11(3):615-626.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  83. HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33
    Authors: Megan Osbourn, Dinesh C. Soares, Francesco Vacca, E. Suzanne Cohen, Ian C. Scott, William F. Gregory et al.
    Immunity
  84. Cyclic stretch induced IL-33 production through HMGB1/TLR-4 signaling pathway in murine respiratory epithelial cells
    Authors: J Chang, Y Xia, K Wasserloos, M Deng, KJ Blose, DA Vorp, HR Turnquist, TR Billiar, BA Pitt, MZ Zhang, LM Zhang
    PLoS ONE, 2017-09-12;12(9):e0184770.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  85. IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3
    Authors: R Lv, J Zhao, M Lei, D Xiao, Y Yu, J Xie
    Cell. Physiol. Biochem., 2017-08-09;42(5):1961-1972.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development (Capture)
  86. IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model
    Authors: J Xu, J Guardado, R Hoffman, H Xu, R Namas, Y Vodovotz, L Xu, M Ramadan, J Brown, HR Turnquist, TR Billiar
    PLoS Med., 2017-07-25;14(7):e1002365.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  87. Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice
    Authors: Zhengxiang He, Lili Chen, Fabricio O. Souto, Claudia Canasto-Chibuque, Gerold Bongers, Madhura Deshpande et al.
    Scientific Reports
  88. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice
    Authors: M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson
    J. Immunol., 2017-07-12;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  89. Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease
    Authors: BW Lewis, R Sultana, R Sharma, A Noël, I Langohr, S Patial, AL Penn, Y Saini
    J. Immunol., 2017-06-30;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  90. Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy
    Authors: Sandra M. Kallert, Stephanie Darbre, Weldy V. Bonilla, Mario Kreutzfeldt, Nicolas Page, Philipp Müller et al.
    Nature Communications
  91. Macrophages produce IL-33 by activating MAPK signaling pathway during RSV infection
    Authors: F Qi, S Bai, D Wang, L Xu, H Hu, S Zeng, R Chai, B Liu
    Mol. Immunol., 2017-05-19;87(0):284-292.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  92. IL-33/ST2-mediated inflammation in macrophages is directly abrogated by IL-10 during rheumatoid arthritis
    Authors: S Chen, B Chen, Z Wen, Z Huang, L Ye
    Oncotarget, 2017-05-16;8(20):32407-32418.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  93. Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis
    Authors: V Carrière, MI Arshad, J Le Seyec, B Lefevre, M Farooq, A Jan, C Manuel, L Touami-Ber, C Lucas-Cler, V Genet, H Gascan, JP Girard, F Chalmel, L Lamontagne, C Piquet-Pel, M Samson
    Mediators Inflamm., 2017-05-04;2017(0):1359064.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  94. IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria
    Authors: F Reverchon, S Mortaud, M Sivoyon, I Maillet, A Laugeray, J Palomo, C Montécot, A Herzine, S Meme, W Meme, F Erard, B Ryffel, A Menuet, VFJ Quesniaux
    PLoS Pathog., 2017-04-27;13(4):e1006322.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  95. Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands
    Authors: H Nakagawa, N Suzuki, Y Hirata, Y Hikiba, Y Hayakawa, H Kinoshita, S Ihara, K Uchino, Y Nishikawa, H Ijichi, M Otsuka, J Arita, Y Sakamoto, K Hasegawa, N Kokudo, K Tateishi, K Koike
    Proc. Natl. Acad. Sci. U.S.A., 2017-04-24;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  96. Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice
    Authors: T Sezaki, Y Hirata, T Hagiwara, YI Kawamura, T Okamura, R Takanashi, K Nakano, M Tamura-Nak, LC Burkly, T Dohi
    World J. Gastroenterol., 2017-04-07;23(13):2294-2307.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  97. Experimental atopic dermatitis depends on IL-33R signaling via MyD88 in dendritic cells
    Authors: C Li, I Maillet, C Mackowiak, C Viala, F Di Padova, M Li, D Togbe, V Quesniaux, Y Lai, B Ryffel
    Cell Death Dis, 2017-04-06;8(4):e2735.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  98. A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract
    Authors: JE Oh, DS Oh, HE Jung, HK Lee
    Proc. Natl. Acad. Sci. U.S.A, 2017-01-30;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  99. Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI
    Authors: Diego Martin-Sanchez, Olga Ruiz-Andres, Jonay Poveda, Susana Carrasco, Pablo Cannata-Ortiz, Maria D. Sanchez-Niño et al.
    Journal of the American Society of Nephrology
  100. Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis
    PLoS ONE, 2016-12-19;11(12):e0168080.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  101. IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy
    Proc. Natl. Acad. Sci. U.S.A., 2016-11-07;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  102. Inflammation elevated IL-33 originating from the lung mediates inflammation in acute lung injury
    Authors: Shi-Hui Lin
    Clin. Immunol, 2016-10-28;0(0):.
    Species: Mouse
    Sample Types: In Vivo, Whole Tissue
    Applications: IHC-P, In Vivo
  103. LIPOPOLYSACCHARIDE DOMAINS MODULATE UROVIRULENCE
    Infect Immun, 2016-10-17;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  104. Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells
    Authors: Carl D. Richards, Laura Izakelian, Anisha Dubey, Grace Zhang, Steven Wong, Karen Kwofie et al.
    Mediators of Inflammation
  105. IL-33/ST2 pathway in a bleomycin-induced pulmonary fibrosis model
    Authors: Jiao Xu, Jinxu Zheng, Ping Song, Yanjuan Zhou, Shuhong Guan
    Molecular Medicine Reports
  106. Collagen-induced arthritis and imiquimod-induced psoriasis develop independently of interleukin-33
    Authors: Sara Khaleghparast Athari
    Arthritis Res Ther, 2016-06-18;18(1):143.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  107. Increased expression of upstream TH2-cytokines in a mouse model of viral-induced asthma exacerbation.
    Authors: Mahmutovic Persson I, Akbarshahi H, Menzel M, Brandelius A, Uller L
    J Transl Med, 2016-02-16;14(1):52.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  108. IL-33 amplifies an innate immune response in the degenerating retina
    Authors: Hongkang Xi, Kenneth J. Katschke, Yun Li, Tom Truong, Wyne P. Lee, Lauri Diehl et al.
    Journal of Experimental Medicine
  109. IL-33 reflects dynamics of disease activity in patients with autoimmune hemolytic anemia by regulating autoantibody production.
    Authors: Bu X, Zhang T, Wang C, Ren T, Wen Z
    J Transl Med, 2015-12-16;13(0):381.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  110. IL-33 Signaling Protects from Murine Oxazolone Colitis by Supporting Intestinal Epithelial Function
    Authors: Amanda Waddell, Jefferson E. Vallance, Preston D. Moore, Amy T. Hummel, David Wu, Shiva K. Shanmukhappa et al.
    Inflammatory Bowel Diseases
  111. Pulmonary Epithelial Cell-Derived Cytokine TGF-beta1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.
    Authors: Denney L, Byrne A, Shea T, Buckley J, Pease J, Herledan G, Walker S, Gregory L, Lloyd C
    Immunity, 2015-11-17;43(5):945-58.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: ELISA Development (Capture)
  112. Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation
    Authors: E. Suzanne Cohen, Ian C. Scott, Jayesh B. Majithiya, Laura Rapley, Benjamin P. Kemp, Elizabeth England et al.
    Nature Communications
  113. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway.
    Authors: Liu T, Kanaoka Y, Barrett N, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw T, Katz H, Boyce J
    J Immunol, 2015-09-04;195(8):3537-45.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  114. Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells
    Authors: Elizabeth A. Oczypok, Pavle S. Milutinovic, John F. Alcorn, Anupriya Khare, Lauren T. Crum, Michelle L. Manni et al.
    Journal of Allergy and Clinical Immunology
  115. IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms.
    Authors: Mager L, Riether C, Schurch C, Banz Y, Wasmer M, Stuber R, Theocharides A, Li X, Xia Y, Saito H, Nakae S, Baerlocher G, Manz M, McCoy K, Macpherson A, Ochsenbein A, Beutler B, Krebs P
    J Clin Invest, 2015-05-26;125(7):2579-91.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  116. AMCase is a crucial regulator of type 2 immune responses to inhaled house dust mites.
    Authors: Kim L, Morita R, Kobayashi Y, Eisenbarth S, Lee C, Elias J, Eynon E, Flavell R
    Proc Natl Acad Sci U S A, 2015-05-18;112(22):E2891-9.
    Species: Mouse
    Sample Types: BALF
    Applications: ELISA Development (Capture)
  117. MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease.
    Authors: Millar N, Gilchrist D, Akbar M, Reilly J, Kerr S, Campbell A, Murrell G, Liew F, Kurowska-Stolarska M, McInnes I
    Nat Commun, 2015-04-10;6(0):6774.
    Species: Mouse
    Sample Types: In Vivo, Whole Tissue
    Applications: IHC, Neutralization
  118. Critical role of IL-33 receptor ST2 in experimental cerebral malaria development.
    Authors: Palomo J, Reverchon F, Piotet J, Besnard A, Couturier-Maillard A, Maillet I, Tefit M, Erard F, Mazier D, Ryffel B, Quesniaux V
    Eur J Immunol, 2015-03-20;45(5):1354-65.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  119. Epidermal Expression and Regulation of Interleukin-33 during Homeostasis and Inflammation: Strong Species Differences.
    Authors: Sundnes O, Pietka W, Loos T, Sponheim J, Rankin A, Pflanz S, Bertelsen V, Sitek J, Hol J, Haraldsen G, Khnykin D
    J Invest Dermatol, 2015-03-04;135(7):1771-80.
    Species: Human, Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  120. Inflammation-Induced Expression of the Alarmin Interleukin 33 Can Be Suppressed by Galacto-Oligosaccharides
    Authors: Kim A.T. Verheijden, Peyman Akbari, Linette E.M. Willemsen, Aletta D. Kraneveld, Gert Folkerts, Johan Garssen et al.
    International Archives of Allergy and Immunology
  121. Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation
    Authors: Sudhir Kumar, Marat Khodoun, Eric M. Kettleson, Christopher McKnight, Tiina Reponen, Sergey A. Grinshpun et al.
    Toxicology
  122. Alternaria-derived serine protease activity drives IL-33-mediated asthma exacerbations.
    Authors: Snelgrove R, Gregory L, Peiro T, Akthar S, Campbell G, Walker S, Lloyd C
    J Allergy Clin Immunol, 2014-03-15;134(3):583-592.e6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  123. Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
    Authors: Mamdouh A K Sedhom, Mélanie Pichery, Jenna R Murdoch, Benoit Foligné, Nathalie Ortega, Sylvain Normand et al.
    Gut
  124. IL-33, but Not IL-25, Is Crucial for the Development of House Dust Mite Antigen-Induced Allergic Rhinitis
    Authors: Wakako Nakanishi, Sachiko Yamaguchi, Akira Matsuda, Maho Suzukawa, Akiko Shibui, Aya Nambu et al.
    PLoS ONE
  125. Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.
    Authors: Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R
    Immunity, 2013-10-24;39(5):976-85.
    Species: Human, Mouse
    Sample Types: Cell Culture Supernates, Peritoneal Fluid
    Applications: ELISA Development (Capture)
  126. Airway epithelial cells initiate the allergen response through transglutaminase 2 by inducing IL-33 expression and a subsequent Th2 response.
    Authors: Oh, Keunhee, Seo, Myung Wo, Lee, Ga Young, Byoun, Ok-Jin, Kang, Hye-Ryun, Cho, Sang-Heo, Lee, Dong-Sup
    Respir Res, 2013-03-13;14(0):35.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  127. Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis.
    Authors: Scalfone, Lisa K, Nel, Hendrik, Gagliardo, Lucille, Cameron, Jody L, Al-Shokri, Shaikha, Leifer, Cynthia, Fallon, Padraic, Appleton, Judith A
    Infect Immun, 2013-02-12;81(4):1354-63.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  128. Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency
    Authors: Praxedis Martin, Dominique Talabot-Ayer, Christian Alexander Seemayer, Solenne Vigne, Céline Lamacchia, Emiliana Rodriguez et al.
    Arthritis Research & Therapy
  129. Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12.
    Authors: Paulissen G, El Hour M, Rocks N, Gueders M, Bureau F, Foidart J, Lopez-Otin C, Noel A, Cataldo D
    J Immunol, 2012-09-07;189(8):4135-43.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  130. Transcriptional regulation of murine IL-33 by TLR and non-TLR agonists.
    Authors: Polumuri SK, Jayakar GG, Shirey KA, Roberts ZJ, Perkins DJ, Pitha PM, Vogel SN
    J. Immunol., 2012-05-25;189(1):50-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  131. IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss
    Authors: Mario M. Zaiss, Mariola Kurowska-Stolarska, Christina Böhm, Regina Gary, Carina Scholtysek, Bartosz Stolarski et al.
    The Journal of Immunology
  132. The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation.
    Authors: Byrne SN, Beaugie C, O'Sullivan C, Leighton S, Halliday GM
    Am. J. Pathol., 2011-05-13;179(1):211-22.
    Species: Mouse
    Sample Types: In Vivo, Whole Tissue
    Applications: IHC-Fr, Neutralization
  133. Paracrine IL-33 Stimulation Enhances Lipopolysaccharide-Mediated Macrophage Activation.
    Authors: Ohno T, Oboki K, Morita H
    PLoS ONE, 2011-04-11;6(4):e18404.
    Species: Mouse
    Sample Types: Recombinant Protein, Whole Cells
    Applications: ELISpot Development, Neutralization
  134. Mast cells as sensors of cell injury through IL-33 recognition.
    Authors: Enoksson M, Lyberg K, Moller-Westerberg C, Fallon PG, Nilsson G, Lunderius-Andersson C
    J. Immunol., 2011-01-14;186(4):2523-8.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  135. IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
    Authors: Nelson MP, Christmann BS, Werner JL, Metz AE, Trevor JL, Lowell CA, Steele C
    J. Immunol., 2011-01-10;186(4):2372-81.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  136. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
    Authors: Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
    J. Immunol., 2009-12-15;183(12):7890-7.
    Species: Mouse
    Sample Types: Cell Culture Supernates, Tissue Homogenates, Whole Cells
    Applications: ELISA Development, ELISpot Development, Western Blot
  137. IL-33 shifts macrophage polarization, promoting resistance against Pseudomonas aeruginosa keratitis.
    Authors: Hazlett LD, McClellan SA, Barrett RP, Huang X, Zhang Y, Wu M, Van Rooijen N, Szliter E
    Invest. Ophthalmol. Vis. Sci., 2009-11-05;51(3):1524-32.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  138. Induction of IL-33 expression and activity in central nervous system glia.
    Authors: Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
    J. Leukoc. Biol., 2008-06-13;84(3):631-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  139. Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical synapse development
    Authors: Y Xie, AT Kuan, W Wang, ZT Herbert, O Mosto, O Olukoya, M Adam, S Vu, M Kim, D Tran, N Gómez, C Charpentie, I Sorour, TE Lacey, MY Tolstoruko, BL Sabatini, WA Lee, CC Harwell
    Cell Reports, 2022-02-22;38(8):110416.
  140. Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
    Authors: Gaya M, Barral P, Burbage M et al.
    Cell
  141. Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury
    Authors: Yamakawa D, Tsuboi J, Kasahara K et al.
    Advanced science (Weinheim, Baden-Wurttemberg, Germany)
  142. Osteoblast Hypoxia-Inducible Factor-1a Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway.
    Authors: Kang H, Yang K, Xiao L et al.
    Front Immunol.
  143. Eosinophils regulate intra-adipose axonal plasticity
    Authors: Meng X, Qian X, Ding X et al.
    Proceedings of the National Academy of Sciences of the United States of America

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Mouse IL-33 Antibody
By Sébastien Brot on 10/13/2023
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Adult brain Species: Mouse

Expression of IL-33 (in red) in the mouse cortex, 7 days after traumatic brain injury

Immunocytochemistry/Immunofluorescence Mouse IL-33 Antibody AF3626
Mouse IL-33 Antibody
By Anonymous on 04/06/2021
Application: WB Sample Tested: Aorta tissue Species: Mouse
Western Blot Mouse IL-33 Antibody AF3626
Mouse IL-33 Antibody
By Josh Richards on 01/28/2020
Application: ELISA Sample Tested: Mouse lymphocytes Species: Mouse

Incubated with Protein X suspected of blocking activity of mIL-33

ELISA Mouse IL-33 Antibody AF3626
Mouse IL-33 Antibody
By Anonymous on 10/06/2019
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Spleen tissue Species: Mouse

green: IL-33, red: vimentin

Immunocytochemistry/Immunofluorescence Mouse IL-33 Antibody AF3626
Mouse IL-33 Antibody
By Anonymous on 09/07/2017
Application: ELISA Sample Tested: Lung tissue Species: Mouse