Mouse Nope/IGDCC4 Antibody Summary
Gly22-His953
Accession # Q9EQS9
Applications
Mouse Nope/IGDCC4 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Nope/IGDCC4
Mouse Nope (Neighbor Of Punc E11) was discovered as a gene proximal to the Punc gene on chromosome 9 (1). Punc and Nope are distant members of a subgroup of the immunoglobulin (Ig) superfamily, which include DCC (Deleted in Colorectal Cancer) (2), Caenorhabditis elegans UNC5 (UNC = behaviorally uncoordinated) and its mammalian homologues (rat UNC5H1 and H2, mouse UNC5H2 and H3, and human UNC5H3 and H4) (3), Drosophila Frazzled (4), vertebrate Neogenin (5), and mouse Nope and mouse Punc. Members of this subgroup of the Ig superfamily are type I transmembrane proteins with four Ig domains in their extracellular regions.
Mouse Nope consists of a 21 amino acid (aa) signal peptide, a 933 aa extracellular domain (including four Ig domains, five fibronectin-type III (FnIII) repeats), a 24 aa transmembrane segment, and a 274 aa cytoplasmic domain (1). The extracellular domain of mouse Nope shares 45% aa sequence similarity with mouse Punc. However, the cytoplasmic domains of mouse Nope and mouse Punc do not share aa sequence similarity. Compared to other members of the subgroup of the Ig superfamily, mouse Nope extracellular domain shares 25.8% and 25.2% aa similarity with mouse DCC and mouse Neogenin, respectively. Mouse and human Nope share 90.8% aa sequence similarity. Mouse Nope is expressed mostly in embryonic muscle tissues and in developing and adult nervous systems. The structural similarities between Nope and the guidance receptor of the DCC family suggest that Nope may have similar functions as the DCC family (6‑8).
- Salbaum, J.M. and C. Kappen (2000) Genomics 64:15.
- Fearon et al. (1990) Science 247:49.
- Keino-Masu et al. (1996) Cell 87:175.
- Hong, K. et al. (1999) Cell 97:927.
- Leonardo, E.D. et al. (1997) Nature 386:833.
- Kolodziej et al. (1996) Cell 87:197.
- Meyerhardt (1997) Oncogene 14:1129.
- Vielmetter et al. (1997) Genomics 41:414.
Product Datasheets
Citations for Mouse Nope/IGDCC4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
2
Citations: Showing 1 - 2
Filter your results:
Filter by:
-
Depolarized Hepatocytes Express the Stem/Progenitor Cell Marker Neighbor of Punc E11 After Bile Duct Ligation in Mice
Authors: A Bowe, S Zweerink, V Mück, V Kondylis, S Schulte, T Goeser, D Nierhoff
J. Histochem. Cytochem., 2018-04-06;0(0):2215541876823.
Species: Mouse
Sample Types: Tissue Homogenates, Whole Tissue
Applications: IHC-Fr, Western Blot -
New cell surface markers for murine fetal hepatic stem cells identified through high density complementary DNA microarrays.
Authors: Nierhoff, Dirk, Levoci, Lauretta, Schulte, Sigrid, Goeser, Tobias, Rogler, Leslie E, Shafritz, David A
Hepatology, 2007-08-01;46(2):535-47.
Species: Mouse
Sample Types: Tissue Homogenates, Whole Cells, Whole Tissue
Applications: Flow Cytometry, IHC-Fr, Western Blot
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Mouse Nope/IGDCC4 Antibody
There are currently no reviews for this product. Be the first to review Mouse Nope/IGDCC4 Antibody and earn rewards!
Have you used Mouse Nope/IGDCC4 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
