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Human/Mouse E-Cadherin Antibody

Catalog #: AF748
142 Citations 11 Reviews Datasheet / COA / SDS
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AF748
AF748-SP
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Detection of Human and Mouse E‑Cadherin by Western Blot.
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Citations (142)
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Reviews (11)
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Human/Mouse E-Cadherin Antibody Summary

Species Reactivity
Human, Mouse
Specificity
Detects mouse E-Cadherin in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse E-Cadherin
Asp157-Val709
Accession # P09803
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.5 µg/mL
See below
Simple Western
5 µg/mL
See below
Flow Cytometry
0.25 µg/106 cells
D3 mouse embryonic stem cell line
Immunohistochemistry
5-15 µg/mL
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Dual RNAscope ISH-IHC
5-15 µg/mL
Immersion fixed paraffin-embedded sections of mouse intestine
Immunocytochemistry
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human and Mouse E-Cadherin antibody by Western Blot. View Larger

Detection of Human and Mouse E‑Cadherin by Western Blot. Western blot shows lysates of A431 human epithelial carcinoma cell line, A549 human lung carcinoma cell line, HepG2 human hepatocellular carcinoma cell line, P19 mouse embryonal carcinoma cell line, and 4T1 mouse breast cancer cell line. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for E-Cadherin at approximately 110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry E-Cadherin antibody in D3 Mouse Embryonic Stem Cell Line by Immunocytochemistry (ICC). View Larger

E‑Cadherin in D3 Mouse Embryonic Stem Cell Line. E-Cadherin was detected in immersion fixed D3 mouse embryonic stem cell line using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cell surfaces. View our protocol for Fluorescent ICC Staining of Stem Cells on Coverslips.

Immunohistochemistry E-Cadherin antibody in Mouse Skin by Immunohistochemistry (IHC-Fr). View Larger

E‑Cadherin in Mouse Skin. E-Cadherin was detected in perfusion fixed frozen sections of mouse skin using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; Catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to plasma membranes in keratinocytes. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

Immunocytochemistry E-Cadherin antibody in Mouse Intestinal Organoids by Immunocytochemistry (ICC). View Larger

E‑Cadherin in Mouse Intestinal Organoids. E-Cadherin was detected in immersion fixed mouse intestinal organoids using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (green; Catalog # NL001) and counterstained with DAPI (blue). Magnification shown at 100X (upper panel) and 40X (lower panel). Specific staining was localized to cell surfaces. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunocytochemistry E-Cadherin antibody in Mouse Intestinal Organoids by Immunocytochemistry (ICC). View Larger

E‑Cadherin in Mouse Intestinal Organoids. E-Cadherin was detected in immersion fixed mouse intestinal organoids using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green; Catalog # NL003) and counterstained with DAPI (blue). Specific staining was localized to cell surfaces. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Immunohistochemistry E-Cadherin antibody in Mouse Spinal Cord by Immunohistochemistry (IHC-Fr). View Larger

E‑Cadherin in Mouse Spinal Cord. E-Cadherin was detected in perfusion fixed frozen sections of mouse spinal cord using Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) at 1.7 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to dorsal horn. View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.

Simple Western Detection of Human and Mouse E-Cadherin antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Human and Mouse E‑Cadherin by Simple WesternTM. Simple Western lane view shows lysates of 4T1 mouse breast cancer cell line, P19 mouse embryonal carcinoma cell line, A431 human epithelial carcinoma cell line, and MCF-7 human breast cancer cell line, loaded at 0.2 mg/mL. A specific band was detected for E-Cadherin at approximately 128 kDa (as indicated) using 5 µg/mL of Goat Anti-Human/Mouse E-Cadherin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF748) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Immunocytochemistry/ Immunofluorescence Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence Retention of the spermatogonial phenotype following gene correction.Immunostaining was performed on gene-corrected GT59 (left) and GT65 cells (right): DAZL, a germ cell specific marker; GFRA1, POU5F1, ETV5, CDH1, and SOHLH1, markers of undifferentiated spermatogonia. Additionally, GT59 and GT65 cells were treated with the differentiation factor, retinoic acid (1 µM) or a vehicle control and then immunostained to examine levels of ZBTB16, a marker of undifferentiated spermatogonia. Bar represents 50 microns. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/25409432), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence Localization of MAFB in mouse testes.(A) Localization of MAFB in E18.5 mouse testes. Double immunostaining of MAFB with E-cadherin (ECAD), GATA4, or STAR is shown. Nuclei were counterstained with DAPI. The color of each marker is indicated above the images. G; germ cells. S; Sertoli cells. L; Leydig cells. MAFB was specifically detected in Leydig cells and Sertoli cells. (B) Localization of MAFB in adult mouse testes. Double immunostaining of MAFB with E-cadherin (ECAD), KIT, SCP3, PNA Lectin, or vimentin is shown. Nuclei were counterstained with DAPI. The color of each marker is indicated above the images. All seminiferous tubules shown represent stage VII. US; undifferentiated spermatogonia. DS; differentiated spermatogonia. P; pachytene spermatocytes. Sp; spermatids. S; Sertoli cells. L; Leydig cells. MAFB was specifically detected in Leydig cells, Sertoli cells, and pachytene spermatocytes. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0190800), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence Cellular localization of PEDF in testicular spermatogenic cells. Methanol-fixed cells were used to stain premeiotic and meiotic/postmeiotic cells as described in Figure 2. (A) alpha 6-integrin, (B) GFR-alpha, (C) CDH1, (D) and NC—IF staining without the presence of primary antibody. (E) CREM, (F) Boule, (G) Acrosin and (H) NC—IF staining without the presence of primary antibody. Scale bar: 100 μm. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33498962), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence Testis morphogenesis of Mafb KO embryos developed normally.(A) Histological section of WT and KO E18.5 testes stained with HE. No morphological alteration or distribution was detectable. (B and C) Counts of Leydig and Sertoli cells from E18.5 WT and KO testes. Embryonic testes (n = 3 per genotype) were sectioned, and 4 sections for each gonad were randomly selected and stained with the germ cell marker E-cadherin (green) together with either STAR (red) or GATA4 (red). Numbers of STAR-positive cells outside seminiferous tubules (Leydig cells) or GATA4-positive cells inside the tubules (Sertoli cells) were counted per unit area. The values are the mean±S.D. *P<0.05. There was no significant difference between WT and KO cell counts. (D) The expression of genes involved in testes development and function. mRNA expression of the gene markers encoding for PGCs (Oct4), Leydig cells (Cyp17a1, StAR, Insl3, Hsd3b1, and Cyp11a1), and Sertoli cells (Amh, Sox9, and WT1) was determined by qRT-PCR in E18.5 WT and Mafb KO testes. Gene expression levels were normalized to Hprt. The bars represent the mean±SEM of five individuals. *P<0.05. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0190800), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence Localization of MAFB in mouse testes.(A) Localization of MAFB in E18.5 mouse testes. Double immunostaining of MAFB with E-cadherin (ECAD), GATA4, or STAR is shown. Nuclei were counterstained with DAPI. The color of each marker is indicated above the images. G; germ cells. S; Sertoli cells. L; Leydig cells. MAFB was specifically detected in Leydig cells and Sertoli cells. (B) Localization of MAFB in adult mouse testes. Double immunostaining of MAFB with E-cadherin (ECAD), KIT, SCP3, PNA Lectin, or vimentin is shown. Nuclei were counterstained with DAPI. The color of each marker is indicated above the images. All seminiferous tubules shown represent stage VII. US; undifferentiated spermatogonia. DS; differentiated spermatogonia. P; pachytene spermatocytes. Sp; spermatids. S; Sertoli cells. L; Leydig cells. MAFB was specifically detected in Leydig cells, Sertoli cells, and pachytene spermatocytes. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0190800), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence View Larger

Detection of Mouse E-Cadherin by Immunocytochemistry/Immunofluorescence Testis morphogenesis of Mafb KO embryos developed normally.(A) Histological section of WT and KO E18.5 testes stained with HE. No morphological alteration or distribution was detectable. (B and C) Counts of Leydig and Sertoli cells from E18.5 WT and KO testes. Embryonic testes (n = 3 per genotype) were sectioned, and 4 sections for each gonad were randomly selected and stained with the germ cell marker E-cadherin (green) together with either STAR (red) or GATA4 (red). Numbers of STAR-positive cells outside seminiferous tubules (Leydig cells) or GATA4-positive cells inside the tubules (Sertoli cells) were counted per unit area. The values are the mean±S.D. *P<0.05. There was no significant difference between WT and KO cell counts. (D) The expression of genes involved in testes development and function. mRNA expression of the gene markers encoding for PGCs (Oct4), Leydig cells (Cyp17a1, StAR, Insl3, Hsd3b1, and Cyp11a1), and Sertoli cells (Amh, Sox9, and WT1) was determined by qRT-PCR in E18.5 WT and Mafb KO testes. Gene expression levels were normalized to Hprt. The bars represent the mean±SEM of five individuals. *P<0.05. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0190800), licensed under a CC-BY license. Not internally tested by R&D Systems.

In-situ Hybridization View Larger

Detection of E‑Cadherin in mouse intestine. Formalin-fixed paraffin-embedded tissue sections of mouse intestine were probed for E-Cadherin mRNA (ACD RNAScope Probe, catalog # 408651; Fast Red chromogen, ACD catalog # 322360). Adjacent tissue section was processed for immunohistochemistry using goat anti-mouse E-Cadherin polyclonal antibody (R&D Systems catalog # AF748) at 0.5ug/mL with overnight incubation at 4 degrees Celsius followed by incubation with anti-goat IgG VisUCyte HRP Polymer Antibody (Catalog # VC004) and DAB chromogen (yellow-brown). Tissue was counterstained with hematoxylin (blue). Specific staining was localized to glandular cells.

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Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: E-Cadherin

Epithelial (E)‑Cadherin (ECAD), also known as cell-CAM120/80 in the human, uvomorulin in the mouse, Arc-1 in the dog, and L-CAM in the chicken, is a member of the cadherin family of cell adhesion molecules. Cadherins are calcium-dependent transmembrane proteins, which bind to one another in a homophilic manner. On their cytoplasmic side, they associate with the three catenins, alpha, beta, and gamma (plakoglobin). This association links the cadherin protein to the cytoskeleton. Without association with the catenins, the cadherins are non-adhesive. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult. E-Cadherin may also play a role in tumor development, as loss of E-Cadherin has been associated with tumor invasiveness. E-Cadherin is a classical cadherin molecule. Classical cadherins consist of a large extracellular domain which contains DXD and DXNDN repeats responsible for mediating calcium‑dependent adhesion, a single-pass transmembrane domain, and a short carboxy-terminal cytoplasmic domain responsible for interacting with the catenins. E‑Cadherin contains five extracellular calcium-binding domains of approximately 110 amino acids each.

References
  1. Bussemakers, M.J.G. et al. (1993) Mol. Biol. Reports 17:123.
  2. Overduin, M. et al. (1995) Science 267:386.
  3. Takeichi, M. (1991) 251:1451.
Entrez Gene IDs
999 (Human); 12550 (Mouse); 83502 (Rat)
Alternate Names
Arc-1; CAD1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1, E-cadherin (epithelial); Cadherin-1; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324 antigen; CD324; CDH1; CDHE; cell-CAM 120/80; Cell-CAM120/80; ECAD; ECadherin; E-Cadherin; Epithelial cadherin; LCAM; L-CAM; UVOE-Cadherin; Uvomorulin

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Citations for Human/Mouse E-Cadherin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

142 Citations: Showing 1 - 10
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  1. Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance.
    Authors: Liu HX, Ermilov A, Grachtchouk M et al.
    Dev Biol
  2. A Fat4-Dchs1 signal between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching.
    Authors: Mao Y, Francis-West P, Irvine KD.
    Development.
  3. Intestinal transit amplifying cells require METTL3 for growth factor signaling, KRAS expression, and cell survival
    Authors: CH Danan, KE Naughton, KE Hayer, S Vellapan, EA McMillan, Y Zhou, R Matsuda, SK Nettleford, K Katada, LR Parham, X Ma, A Chowdhury, BJ Wilkins, P Shah, MD Weitzman, KE Hamilton
    bioRxiv : the preprint server for biology, 2023-04-21;0(0):.
  4. Effect of ectopic expression of homeoprotein EGAM1C on the cell morphology, growth, and differentiation in a mouse embryonic stem cell line, MG1.19 cells.
    Authors: Iha M, Watanabe M, Kihara Y et al.
    Reproduction.
  5. Clearance of erythrocytes from the subarachnoid space through cribriform plate lymphatics in female mice
    Authors: Madarasz, A;Xin, L;Proulx, ST;
    EBioMedicine
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  6. Rosiglitazone and trametinib exhibit potent anti-tumor activity in a mouse model of muscle invasive bladder cancer
    Authors: Plumber, SA;Tate, T;Al-Ahmadie, H;Chen, X;Choi, W;Basar, M;Lu, C;Viny, A;Batourina, E;Li, J;Gretarsson, K;Alija, B;Molotkov, A;Wiessner, G;Lee, BHL;McKiernan, J;McConkey, DJ;Dinney, C;Czerniak, B;Mendelsohn, CL;
    Nature communications
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  7. Critical role of thrombospondin-1 in promoting intestinal mucosal wound repair
    Authors: Wilson, ZS;Raya-Sandino, A;Miranda, J;Fan, S;Brazil, JC;Quiros, M;Garcia-Hernandez, V;Liu, Q;Kim, CH;Hankenson, KD;Nusrat, A;Parkos, CA;
    JCI insight
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  8. In vivo interaction screening reveals liver-derived constraints to metastasis
    Authors: Borrelli, C;Roberts, M;Eletto, D;Hussherr, MD;Fazilaty, H;Valenta, T;Lafzi, A;Kretz, JA;Guido Vinzoni, E;Karakatsani, A;Adivarahan, S;Mannhart, A;Kimura, S;Meijs, A;Baccouche Mhamedi, F;Acar, IE;Handler, K;Ficht, X;Platt, RJ;Piscuoglio, S;Moor, AE;
    Nature
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  9. Trans-omic profiling uncovers molecular controls of early human cerebral organoid formation
    Authors: Chen, C;Lee, S;Zyner, KG;Fernando, M;Nemeruck, V;Wong, E;Marshall, LL;Wark, JR;Aryamanesh, N;Tam, PPL;Graham, ME;Gonzalez-Cordero, A;Yang, P;
    Cell reports
    Species: Human
    Sample Types: Organoid
    Applications: Immunohistochemistry
  10. Venous-plexus-associated lymphoid hubs support meningeal humoral immunity
    Authors: Fitzpatrick, Z;Ghabdan Zanluqui, N;Rosenblum, JS;Tuong, ZK;Lee, CYC;Chandrashekhar, V;Negro-Demontel, ML;Stewart, AP;Posner, DA;Buckley, M;Allinson, KSJ;Mastorakos, P;Chittiboina, P;Maric, D;Donahue, D;Helmy, A;Tajsic, T;Ferdinand, JR;Portet, A;Peñalver, A;Gillman, E;Zhuang, Z;Clatworthy, MR;McGavern, DB;
    Nature
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  11. Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation
    Authors: Liu, J;Prahl, LS;Huang, A;Hughes, AJ;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  12. Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival
    Authors: Danan, CH;Naughton, KE;Hayer, KE;Vellappan, S;McMillan, EA;Zhou, Y;Matsuda, R;Nettleford, SK;Katada, K;Parham, LR;Ma, X;Chowdhury, A;Wilkins, BJ;Shah, P;Weitzman, MD;Hamilton, KE;
    JCI insight
    Species: Transgenic Mouse
    Sample Types: Organoid
    Applications: Immunohistochemistry
  13. Transcriptomic analysis reveals partial epithelial-mesenchymal transition and inflammation as common pathogenic mechanisms in hypertensive nephrosclerosis and Type 2 diabetic nephropathy
    Authors: Nordbø, OP;Landolt, L;Eikrem, Ø;Scherer, A;Leh, S;Furriol, J;Apeland, T;Mydel, P;Marti, HP;
    Physiological reports
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  14. Spatial-temporal proliferation of hepatocytes during pregnancy revealed by genetic lineage tracing
    Authors: He, S;Guo, Z;Zhou, M;Wang, H;Zhang, Z;Shi, M;Li, X;Yang, X;He, L;
    Cell stem cell
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation
    Authors: Mapunda JA, Pareja J, Vladymyrov M et al.
    Nat Commun
  16. Coordination between ECM and cell-cell adhesion regulates the development of islet aggregation, architecture, and functional maturation
    Authors: Tixi W, Maldonado M, Chang YT et al.
    eLife
  17. An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo
    Authors: Liu, K;Tang, M;Xu, W;Meng, X;Jin, H;Han, M;Pu, J;Li, Y;Jiao, F;Sun, R;Shen, R;Lui, KO;Lu, L;Zhou, B;
    Proceedings of the National Academy of Sciences of the United States of America
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  18. Bacterial meningitis in the early postnatal mouse studied at single-cell resolution
    Authors: Wang J, Rattner A, Nathans J
    eLife
  19. Genetic recording of in vivo cell proliferation by ProTracer
    Authors: Liu, X;Weng, W;He, L;Zhou, B;
    Nature protocols
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  20. Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene-environment interaction
    Authors: Alvizi, L;Nani, D;Brito, LA;Kobayashi, GS;Passos-Bueno, MR;Mayor, R;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  21. Opposing roles for TGF?- and BMP-signaling during nascent alveolar differentiation in the developing human lung
    Authors: Frum, T;Hsu, PP;Hein, RFC;Conchola, AS;Zhang, CJ;Utter, OR;Anand, A;Zhang, Y;Clark, SG;Glass, I;Sexton, JZ;Spence, JR;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  22. IGFBP2 expressing midlobular hepatocytes preferentially contribute to liver homeostasis and regeneration
    Authors: Lin, YH;Wei, Y;Zeng, Q;Wang, Y;Pagani, CA;Li, L;Zhu, M;Wang, Z;Hsieh, MH;Corbitt, N;Zhang, Y;Sharma, T;Wang, T;Zhu, H;
    Cell stem cell
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  23. Role of enterocyte Enpp2 and autotaxin in regulating lipopolysaccharide levels, systemic inflammation, and atherosclerosis
    Authors: Arnab Chattopadhyay, Pallavi Mukherjee, Dawoud Sulaiman, Huan Wang, Victor Girjalva, Nasrin Dorreh et al.
    Journal of Lipid Research
  24. Non-optimal bacteria species induce neutrophil-driven inflammation and barrier disruption in the female genital tract
    Authors: M Costa Fuji, A Yazdanpana, S Horne, A Lamont, P Lopez, C Farr Zuend, K Birse, M Taverner, R Greenslade, M Abou, L Noel-Romas, B Abrenica, O Ajibola, N Ikeogu, RC Su, LR McKinnon, H Pymar, V Poliquin, AR Berard, A Burgener, TT Murooka
    Mucosal Immunology, 2023-04-29;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  25. Uropathogenic Escherichia coli infection-induced epithelial trained immunity impacts urinary tract disease outcome
    Authors: SK Russell, JK Harrison, BS Olson, HJ Lee, VP O'Brien, X Xing, J Livny, L Yu, EDO Roberson, R Bomjan, C Fan, M Sha, S Estfanous, AO Amer, M Colonna, TS Stappenbec, T Wang, TJ Hannan, SJ Hultgren
    Nature Microbiology, 2023-04-10;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  26. Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves
    Authors: I Spera, N Cousin, M Ries, A Kedracka, A Castillo, S Aleandri, M Vladymyrov, JA Mapunda, B Engelhardt, P Luciani, M Detmar, ST Proulx
    EBioMedicine, 2023-04-10;91(0):104558.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  27. PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice
    Authors: Vinicius Canale, Marianne R. Spalinger, Rocio Alvarez, Anica Sayoc-Becerra, Golshid Sanati, Salomon Manz et al.
    Cellular and Molecular Gastroenterology and Hepatology
  28. Taste papilla cell differentiation requires tongue mesenchyme via ALK3-BMP signaling to regulate the production of secretory proteins
    Authors: M Ishan, Z Wang, P Zhao, Y Yao, S Stice, L Wells, Y Mishina, HX Liu
    bioRxiv : the preprint server for biology, 2023-04-04;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  29. EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids
    Authors: Charlie J. Childs, Emily M. Holloway, Caden W. Sweet, Yu-Hwai Tsai, Angeline Wu, Abigail Vallie et al.
    JCI Insight
  30. Non-canonical functions of SNAIL drive context-specific cancer progression
    Authors: MC Paul, C Schneeweis, C Falcomatà, C Shan, D Rossmeisl, S Koutsouli, C Klement, M Zukowska, SA Widholz, M Jesinghaus, KK Heuermann, T Engleitner, B Seidler, K Sleiman, K Steiger, M Tschurtsch, B Walter, SA Weidemann, R Pietsch, A Schnieke, RM Schmid, MS Robles, G Andrieux, M Boerries, R Rad, G Schneider, D Saur
    Nature Communications, 2023-03-07;14(1):1201.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  31. Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection
    Authors: AT Tang, DW Buchholz, KM Szigety, B Imbiakha, S Gao, M Frankfurte, M Wang, J Yang, P Hewins, P Mericko-Is, NA Leu, S Sterling, IA Monreal, J Sahler, A August, X Zhu, KA Jurado, M Xu, EE Morrisey, SE Millar, HC Aguilar, ML Kahn
    PloS Biology, 2023-02-06;21(2):e3001989.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  32. Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells
    Authors: W Zhang, Z Xu, X Hao, T He, J Li, Y Shen, K Liu, Y Gao, J Liu, D Edwards, AM Muscarella, L Wu, L Yu, L Xu, X Chen, YH Wu, IL Bado, Y Ding, S Aguirre, H Wang, Z Gugala, RL Satcher, ST Wong, XH Zhang
    Cancer Discovery, 2023-02-06;0(0):.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  33. Arginase-1 inhibition reduces migration ability and metastatic colonization of colon cancer cells
    Authors: Xiangdong Wang, Huihui Xiang, Yujiro Toyoshima, Weidong Shen, Shunsuke Shichi, Hiroki Nakamoto et al.
    Cancer & Metabolism
  34. Non-canonical functions of SNAIL drive context-specific cancer progression
    Authors: MC Paul, C Schneeweis, C Falcomatà, C Shan, D Rossmeisl, S Koutsouli, C Klement, M Zukowska, SA Widholz, M Jesinghaus, KK Heuermann, T Engleitner, B Seidler, K Sleiman, K Steiger, M Tschurtsch, B Walter, SA Weidemann, R Pietsch, A Schnieke, RM Schmid, MS Robles, G Andrieux, M Boerries, R Rad, G Schneider, D Saur
    Nature Communications, 2023;14(1):1201.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  35. Multiscale profiling of protease activity in cancer
    Authors: AP Amini, JD Kirkpatric, CS Wang, AM Jaeger, S Su, S Naranjo, Q Zhong, CM Cabana, T Jacks, SN Bhatia
    Nature Communications, 2022-10-03;13(1):5745.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  36. The NALCN channel regulates metastasis and nonmalignant cell dissemination
    Authors: EP Rahrmann, D Shorthouse, A Jassim, LP Hu, M Ortiz, B Mahler-Ara, P Vogel, M Paez-Ribes, A Fatemi, GJ Hannon, R Iyer, JA Blundon, FC Lourenço, J Kay, RM Nazarian, BA Hall, SS Zakharenko, DJ Winton, L Zhu, RJ Gilbertson
    Nature Genetics, 2022-09-29;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  37. Focal adhesion kinase-mediated signaling controls the onset of pancreatic cell differentiation
    Authors: Uylissa A. Rodriguez, Shakti Dahiya, Michelle L. Raymond, Chenxi Gao, Christina P. Martins-Cargill, Jon D. Piganelli et al.
    Development
  38. Adherens junctions stimulate and spatially guide integrin activation and extracellular matrix deposition
    Authors: R Hadjisavva, O Anastasiou, PS Ioannou, M Zheltkova, PA Skourides
    Oncogene, 2022-07-19;40(3):111091.
    Species: Xenopus
    Sample Types: Embryos
    Applications: IHC
  39. Lymphatics act as a signaling hub to regulate intestinal stem cell activity
    Authors: RE Niec, T Chu, M Schernthan, S Gur-Cohen, L Hidalgo, HA Pasolli, KA Luckett, Z Wang, SR Bhalla, F Cambuli, RP Kataru, K Ganesh, BJ Mehrara, D Pe'er, E Fuchs
    Cell Stem Cell, 2022-06-20;29(7):1067-1082.e18.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Tissue Homogenates
    Applications: Western Blot
  40. Ex Vivo Perfusion Using a Mathematical Modeled, Controlled Gas Exchange Self-Contained Bioreactor Can Maintain a Mouse Kidney for Seven Days
    Authors: N Won, J Castillo-P, X Tan, J Ford, D Heath, LI Mazilescu, M Selzner, IM Rogers
    Cells, 2022-06-02;11(11):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  41. Dual Cre and Dre recombinases mediate synchronized lineage tracing and cell subset ablation in vivo
    Authors: Haixiao Wang, Lingjuan He, Yan Li, Wenjuan Pu, Shaohua Zhang, Ximeng Han et al.
    Journal of Biological Chemistry
  42. A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair.
    Authors: Susana L, Alexander C, Afshin K et al.
    FASEB J.
  43. Cyclic GMP‐AMP synthase contributes to epithelial homeostasis in intestinal inflammation via Beclin‐1‐mediated autophagy
    Authors: Sidrah Khan, Heather L. Mentrup, Elizabeth A. Novak, Vei Shaun Siow, Qian Wang, Erin C. Crawford et al.
    The FASEB Journal
  44. Amniogenesis occurs in two independent waves in primates
    Authors: M Rostovskay, S Andrews, W Reik, PJ Rugg-Gunn
    Cell Stem Cell, 2022-04-18;29(5):744-759.e6.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  45. Loss of Rnf31 and Vps4b sensitizes pancreatic cancer to T cell-mediated killing
    Authors: N Frey, L Tortola, D Egli, S Janjuha, T Rothgangl, KF Marquart, F Ampenberge, M Kopf, G Schwank
    Nature Communications, 2022-04-04;13(1):1804.
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  46. Generation of human tonsil epithelial organoids as an ex vivo model for SARS-CoV-2 infection
    Authors: Han Kyung Kim, Hyeryeon Kim, Myoung Kyu Lee, Woo Hee Choi, Yejin Jang, Jin Soo Shin et al.
    Biomaterials
  47. Neuroinflammation creates an immune regulatory niche at the meningeal lymphatic vasculature near the cribriform plate
    Authors: Martin Hsu, Collin Laaker, Andy Madrid, Melinda Herbath, Yun Hwa Choi, Matyas Sandor et al.
    Nature Immunology
  48. Suspension culture promotes serosal mesothelial development in human intestinal organoids
    Authors: MM Capeling, S Huang, CJ Childs, JH Wu, YH Tsai, A Wu, N Garg, EM Holloway, N Sundaram, C Bouffi, M Helmrath, JR Spence
    Cell Reports, 2022-02-15;38(7):110379.
    Species: Human
    Sample Types: Oraganoids
    Applications: IHC
  49. Fundamentals of vaping-associated pulmonary injury leading to severe respiratory distress
    Authors: Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Clarissa Savko, Grant Shain, Pria Bose et al.
    Life Science Alliance
  50. Macrophage COX2 Mediates Efferocytosis, Resolution Reprogramming, and Intestinal Epithelial Repair
    Authors: David Meriwether, Anthony E. Jones, Julianne W. Ashby, R. Sergio Solorzano-Vargas, Nasrin Dorreh, Shoreh Noori et al.
    Cellular and Molecular Gastroenterology and Hepatology
  51. Oxidized phospholipids cause changes in jejunum mucus that induce dysbiosis and systemic inflammation
    Authors: Pallavi Mukherjee, Arnab Chattopadhyay, Victor Grijalva, Nasrin Dorreh, Venu Lagishetty, Jonathan P. Jacobs et al.
    Journal of Lipid Research
  52. E-Cadherin-Deficient Epithelial Cells Are Sensitive to HDAC Inhibitors
    Authors: L Decourtye-, N Bougen-Zhu, T Godwin, T Brew, E Schulpen, MA Black, P Guilford
    Cancers, 2021-12-30;14(1):.
    Species: Mouse
    Sample Types: Organoids
    Applications: IHC, Western Blot
  53. Loss of E-Cadherin Leads to Druggable Vulnerabilities in Sphingolipid Metabolism and Vesicle Trafficking
    Authors: T Brew, N Bougen-Zhu, W Mitchell, L Decourtye, E Schulpen, Y Nouri, T Godwin, P Guilford
    Cancers, 2021-12-26;14(1):.
    Species: Transgenic Mouse
    Sample Types: Organoids
    Applications: IHC
  54. Deletion of Nf2 in neural crest‐derived tongue mesenchyme alters tongue shape and size, Hippo signalling and cell proliferation in a region‐ and stage‐specific manner
    Authors: Mohamed Ishan, Guiqian Chen, Wenxin Yu, Zhonghou Wang, Marco Giovannini, Xinwei Cao et al.
    Cell Proliferation
  55. Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures
    Authors: K Gkatzis, P Panza, S Peruzzo, DY Stainier
    Elife, 2021-09-29;10(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: IHC
  56. Signaling Modulation by miRNA-221-3p During Tooth Morphogenesis in Mice
    Authors: Yam Prasad Aryal, Tae-Young Kim, Eui-Seon Lee, Chang-Hyeon An, Ji-Youn Kim, Hitoshi Yamamoto et al.
    Frontiers in Cell and Developmental Biology
  57. Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis
    Authors: D Basak, Z Jamal, A Ghosh, PK Mondal, P Dey Talukd, S Ghosh, B Ghosh Roy, R Ghosh, A Halder, A Chowdhury, GK Dhali, BK Chattopadh, ML Saha, A Basu, S Roy, C Mukherjee, NK Biswas, U Chatterji, S Datta
    PLoS ONE, 2021-08-11;16(8):e0255915.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  58. M1 Macrophage-Derived Nanovesicles Repolarize M2 Macrophages for Inhibiting the Development of Endometriosis
    Authors: Qiuju Li, Ming Yuan, Xue Jiao, Yufei Huang, Jing Li, Dong Li et al.
    Frontiers in Immunology
  59. Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19
    Authors: Ji Hoon Ahn, JungMo Kim, Seon Pyo Hong, Sung Yong Choi, Myung Jin Yang, Young Seok Ju et al.
    Journal of Clinical Investigation
  60. Charting human development using a multi-endodermal organ atlas and organoid models
    Authors: Qianhui Yu, Umut Kilik, Emily M. Holloway, Yu-Hwai Tsai, Christoph Harmel, Angeline Wu et al.
    Cell
  61. Microtissue Geometry and Cell‐Generated Forces Drive Patterning of Liver Progenitor Cell Differentiation in 3D
    Authors: Ian C. Berg, Erfan Mohagheghian, Krista Habing, Ning Wang, Gregory H. Underhill
    Advanced Healthcare Materials
  62. In vitro models of fetal lung development to enhance research into congenital lung diseases
    Authors: Soichi Shibuya, Jessica Allen-Hyttinen, Paolo De Coppi, Federica Michielin
    Pediatric Surgery International
  63. Homophilic and heterophilic cadherin bond rupture forces in homo- or hetero-cellular systems measured by AFM-based single-cell force spectroscopy
    Authors: Prem Kumar Viji Babu, Ursula Mirastschijski, Ganzanfer Belge, Manfred Radmacher
    European Biophysics Journal
  64. Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells
    Authors: Takashi Ogino, Naoya Matsunaga, Takahiro Tanaka, Tomohito Tanihara, Hideki Terajima, Hikari Yoshitane et al.
    eLife
  65. Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis
    Authors: D Yamakawa, D Katoh, K Kasahara, T Shiromizu, M Matsuyama, C Matsuda, Y Maeno, M Watanabe, Y Nishimura, M Inagaki
    Cell Reports, 2021-03-09;34(10):108817.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  66. Paneth cell–derived growth factors support tumorigenesis in the small intestine
    Authors: Qing Chen, Kohei Suzuki, Luis Sifuentes-Dominguez, Naoteru Miyata, Jie Song, Adam Lopez et al.
    Life Science Alliance
  67. The Presence of Colony-Stimulating Factor-1 and Its Receptor in Different Cells of the Testis; It Involved in the Development of Spermatogenesis In Vitro
    Authors: Sawaied A, Arazi E, AbuElhija A et al.
    International Journal of Molecular Sciences
  68. Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis
    Authors: P Lu, Y Yamaguchi, WB Fulton, S Wang, Q Zhou, H Jia, ML Kovler, AG Salazar, M Sampah, T Prindle, P Wipf, CP Sodhi, DJ Hackam
    Nature Communications, 2021-02-15;12(1):1042.
    Species: Human, Mouse, Porcine
    Sample Types: Whole Tissue
    Applications: IHC
  69. The Expression Levels and Cellular Localization of Pigment Epithelium Derived Factor (PEDF) in Mouse Testis: Its Possible Involvement in the Differentiation of Spermatogonial Cells
    Authors: N Bagdadi, A Sawaied, A AbuMadighe, E Lunenfeld, M Huleihel
    International Journal of Molecular Sciences, 2021-01-24;22(3):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  70. Mapping Development of the Human Intestinal Niche at Single-Cell Resolution
    Authors: EM Holloway, M Czerwinski, YH Tsai, JH Wu, A Wu, CJ Childs, KD Walton, CW Sweet, Q Yu, I Glass, B Treutlein, JG Camp, JR Spence
    Cell Stem Cell, 2020-12-04;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  71. Tim-3 promotes cell aggressiveness and paclitaxel resistance through NF-kappa B/STAT3 signalling pathway in breast cancer cells
    Authors: Yizi Cong, Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250033, China, Yuxin Cui, Shiguang Zhu, Jianqiao Cao, Haidong Zou et al.
    Chinese Journal of Cancer Research
  72. Developmental Roles of FUSE Binding Protein 1 (Fubp1) in Tooth Morphogenesis
    Authors: Yam Prasad Aryal, Sanjiv Neupane, Tae-Young Kim, Eui-Seon Lee, Nitin Kumar Pokhrel, Chang-Yeol Yeon et al.
    International Journal of Molecular Sciences
  73. Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2
    Authors: J Youk, T Kim, KV Evans, YI Jeong, Y Hur, SP Hong, JH Kim, K Yi, SY Kim, KJ Na, T Bleazard, HM Kim, M Fellows, KT Mahbubani, K Saeb-Parsy, SY Kim, YT Kim, GY Koh, BS Choi, YS Ju, JH Lee
    Cell Stem Cell, 2020-10-21;27(6):905-919.e10.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  74. RUNX1 marks a luminal castration-resistant lineage established at the onset of prostate development
    Authors: Renaud Mevel, Ivana Steiner, Susan Mason, Laura CA Galbraith, Rahima Patel, Muhammad ZH Fadlullah et al.
    eLife
  75. Mycotoxin Deoxynivalenol Has Different Impacts on Intestinal Barrier and Stem Cells by Its Route of Exposure
    Authors: H Hanyu, Y Yokoi, K Nakamura, T Ayabe, K Tanaka, K Uno, K Miyajima, Y Saito, K Iwatsuki, M Shimizu, M Tadaishi, K Kobayashi-
    Toxins (Basel), 2020-09-24;12(10):.
    Species: Mouse
    Sample Types: Organoid
    Applications: IHC
  76. Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth
    Authors: Krivanek J, Soldatov RA, Kastriti ME et al.
    Nature Communications
  77. Calcium-Binding Protein S100P Promotes Tumor Progression but Enhances Chemosensitivity in Breast Cancer
    Authors: Yizi Cong, Yuxin Cui, Suxia Wang, Lei Jiang, Jianqiao Cao, Shiguang Zhu et al.
    Frontiers in Oncology
  78. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi
    Authors: SP Hong, MJ Yang, H Cho, I Park, H Bae, K Choe, SH Suh, RH Adams, K Alitalo, D Lim, GY Koh
    Nat Commun, 2020-08-14;11(1):4102.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  79. Three-Dimensional Imaging and Gene Expression Analysis Upon Enzymatic Isolation of the Tongue Epithelium
    Authors: Christian T. Meisel, Pierfrancesco Pagella, Cristina Porcheri, Thimios A. Mitsiadis
    Frontiers in Physiology
  80. Dysregulation of intestinal epithelial CFTR-dependent Cl- ion transport and paracellular barrier function drives gastrointestinal symptoms of food-induced anaphylaxis in mice
    Authors: A Yamani, D Wu, R Ahrens, L Waggoner, TK Noah, V Garcia-Her, C Ptaschinsk, CA Parkos, NW Lukacs, A Nusrat, SP Hogan
    Mucosal Immunol, 2020-06-23;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  81. Genetic and structural analysis of the in vivo functional redundancy between murine NANOS2 and NANOS3
    Authors: Danelle Wright, Makoto Kiso, Yumiko Saga
    Development
  82. CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs
    Authors: J Jin, IH Jung, SH Moon, S Jeon, SJ Jeong, SK Sonn, S Seo, MN Lee, EJ Song, HY Kweon, S Kim, TK Kim, J Kim, HR Cho, JH Choi, B Kwon, GT Oh
    Cell Rep, 2020-03-24;30(12):4124-4136.e5.
    Species: Mouse
    Sample Types: Colon Tissue
    Applications: IHC
  83. Desmocollin-2 promotes intestinal mucosal repair by controlling integrin-dependent cell adhesion and migration
    Authors: Sven Flemming, Anny-Claude Luissint, Dennis H. M. Kusters, Arturo Raya-Sandino, Shuling Fan, Dennis W. Zhou et al.
    Molecular Biology of the Cell
  84. Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-&beta Resistance
    Authors: T Ringel, N Frey, F Ringnalda, S Janjuha, S Cherkaoui, S Butz, S Srivatsa, M Pirkl, G Russo, L Villiger, G Rogler, H Clevers, N Beerenwink, N Zamboni, T Baubec, G Schwank
    Cell Stem Cell, 2020-03-05;26(3):431-440.e8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  85. Downregulation of SETD7 promotes migration and invasion of lung cancer cells via JAK2/STAT3 pathway
    Authors: Limin Cao, Yinghui Ren, Xueru Guo, Limin Wang, Qicheng Zhang, Xueqin Li et al.
    International Journal of Molecular Medicine
  86. Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1
    Authors: Kendall J. Lough, Danielle C. Spitzer, Abby J. Bergman, Jessica J. Wu, Kevin M. Byrd, Scott E. Williams
    Development
  87. Increased activity of mesenchymal ALK2‐BMP signaling causes posteriorly truncated microglossia and disorganization of lingual tissues
    Authors: Mohamed Ishan, Guiqian Chen, Chenming Sun, Shi‐You Chen, Yoshihiro Komatsu, Yuji Mishina et al.
    genesis
  88. A novel role for necroptosis in the pathogenesis of necrotizing enterocolitis
    Authors: AD Werts, WB Fulton, MR Ladd, A Saad-Eldin, YX Chen, ML Kovler, H Jia, EC Banfield, R Buck, K Goerhing, T Prindle, S Wang, Q Zhou, P Lu, Y Yamaguchi, CP Sodhi, DJ Hackam
    Cell Mol Gastroenterol Hepatol, 2019-11-19;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  89. Lack of whey acidic protein four disulphide core (WFDC) 2 protease inhibitor causes neonatal death from respiratory failure in mice
    Authors: K Nakajima, M Ono, U Radovi?, S Dizdarevi?, SI Tomizawa, K Kuroha, G Naganatsu, I Hoshi, R Matsunaga, T Shirakawa, T Kurosawa, Y Miyazaki, M Seki, Y Suzuki, H Koseki, M Nakamura, T Suda, K Ohbo
    Dis Model Mech, 2019-11-12;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  90. Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo
    Authors: M Reed, AC Luissint, V Azcutia, S Fan, MN O'Leary, M Quiros, J Brazil, A Nusrat, CA Parkos
    Nat Commun, 2019-11-01;10(1):5004.
    Species: Mouse
    Sample Types: Cells
    Applications: IF
  91. Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
    Authors: C Liu, T Tate, E Batourina, ST Truschel, S Potter, M Adam, T Xiang, M Picard, M Reiley, K Schneider, M Tamargo, C Lu, X Chen, J He, H Kim, CL Mendelsohn
    Nat Commun, 2019-10-09;10(1):4589.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  92. Pharmacological reversal of renal cysts from secretion to absorption suggests a potential therapeutic strategy for managing polycystic kidney disease
    Authors: MK Yanda, B Cha, C Cebotaru, L Cebotaru
    J. Biol. Chem., 2019-09-30;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Confocal Microscopy
  93. Disruption of Robo2-Baiap2 integrated signaling drives cystic disease
    Authors: Qinggang Li, Shaoyuan Cui, Qian Ma, Ying Liu, Hongyu Yu, GuangRui Geng et al.
    JCI Insight
  94. Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer
    Authors: DM Gay, RA Ridgway, M Müeller, MC Hodder, A Hedley, W Clark, JD Leach, R Jackstadt, C Nixon, DJ Huels, AD Campbell, TG Bird, OJ Sansom
    Nat Commun, 2019-02-13;10(1):723.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Proximity Ligation Assay (PLA)
  95. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA
    Authors: MA Scavuzzo, J Chmielowie, D Yang, K Wamble, LS Chaboub, L Duraine, B Tepe, SM Glasgow, BR Arenkiel, C Brou, B Deneen, M Borowiak
    Cell Rep, 2018-12-26;25(13):3811-3827.e7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  96. Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner
    Authors: VP O'Brien, DA Dorsey, TJ Hannan, SJ Hultgren
    PLoS Pathog., 2018-12-13;14(12):e1007457.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  97. A novel role for C–C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis
    Authors: Micah D. Dunlap, Nicole Howard, Shibali Das, Ninecia Scott, Mushtaq Ahmed, Oliver Prince et al.
    Mucosal Immunology
  98. Analysis of leukocyte transepithelial migration using an in vivo murine colonic loop model
    Authors: S Flemming, AC Luissint, A Nusrat, CA Parkos
    JCI Insight, 2018-10-18;3(20):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  99. Polyploid Superficial Cells that Maintain the Urothelial Barrier Are Produced via Incomplete Cytokinesis and Endoreplication
    Authors: J Wang, E Batourina, K Schneider, S Souza, T Swayne, C Liu, CD George, T Tate, H Dan, G Wiessner, Y Zhuravlev, JC Canman, IU Mysorekar, CL Mendelsohn
    Cell Rep, 2018-10-09;25(2):464-477.e4.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  100. Activated natural killer T cells in mice induce acute kidney injury with hematuria through possibly common mechanisms shared by human CD56+ T cells
    Authors: Takahiro Uchida, Hiroyuki Nakashima, Seigo Ito, Takuya Ishikiriyama, Masahiro Nakashima, Shuhji Seki et al.
    American Journal of Physiology-Renal Physiology
  101. Liver regeneration requires Yap1-TGF beta -dependent epithelial-mesenchymal transition in hepatocytes
    Authors: Seh-Hoon Oh, Marzena Swiderska-Syn, Mark L. Jewell, Richard T. Premont, Anna Mae Diehl
    Journal of Hepatology
  102. Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance
    Authors: Aysegül Kaymak, Sergi Sayols, Thaleia Papadopoulou, Holger Richly
    Oncotarget
  103. GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance
    Authors: Hue M. La, Ai-Leen Chan, Julien M. D. Legrand, Fernando J. Rossello, Christina G. Gangemi, Antonella Papa et al.
    Development
  104. Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination
    Authors: O Nekrasova, RM Harmon, JA Broussard, JL Koetsier, LM Godsel, GN Fitz, ML Gardel, KJ Green
    Nat Commun, 2018-03-13;9(1):1053.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  105. Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion
    Authors: Masato Hoshi, Antoine Reginensi, Matthew S. Joens, James A. J. Fitzpatrick, Helen McNeill, Sanjay Jain
    Journal of the American Society of Nephrology
  106. NANOS2 acts as an intrinsic regulator of gonocytes-to-spermatogonia transition in the murine testes
    Authors: HP Pui, Y Saga
    Mech. Dev., 2018-01-12;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  107. Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer
    Authors: E Sakai, M Nakayama, H Oshima, Y Kouyama, A Niida, S Fujii, A Ochiai, KI Nakayama, K Mimori, Y Suzuki, CP Hong, CY Ock, SJ Kim, M Oshima
    Cancer Res., 2017-12-27;0(0):.
  108. Multicolor quantitative confocal imaging cytometry
    Authors: DL Coutu, KD Kokkaliari, L Kunz, T Schroeder
    Nat. Methods, 2017-11-13;15(1):39-46.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  109. Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic ? Cell Hyperplasia in Mice
    Authors: J Kim, H Okamoto, Z Huang, G Anguiano, S Chen, Q Liu, K Cavino, Y Xin, E Na, R Hamid, J Lee, B Zambrowicz, R Unger, AJ Murphy, Y Xu, GD Yancopoulo, WH Li, J Gromada
    Cell Metab., 2017-06-06;25(6):1348-1361.e8.
  110. Distinct Requirements for FGFR1 and FGFR2 in Primitive Endoderm Development and Exit from Pluripotency
    Authors: A Molotkov, P Mazot, JR Brewer, RM Cinalli, P Soriano
    Dev. Cell, 2017-05-25;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  111. Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection
    Authors: P Treerat, O Prince, A Cruz-Lagun, M Muñoz-Torr, MA Salazar-Le, M Selman, B Fallert-Ju, TA Reinhardt, JF Alcorn, D Kaushal, J Zuñiga, J Rangel-Mor, JK Kolls, SA Khader
    Mucosal Immunol, 2017-03-01;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  112. Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling
    PLoS Genet, 2016-11-28;12(11):e1006442.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  113. A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease
    Nat Microbiol, 2016-10-31;2(0):16196.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  114. Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress
    Authors: Wakana Ohashi, Shunsuke Kimura, Toshihiko Iwanaga, Yukihiro Furusawa, Tarou Irié, Hironori Izumi et al.
    PLOS Genetics
  115. Western diet enhances benzo(a)pyrene-induced colon tumorigenesis in a polyposis in rat coli (PIRC) rat model of colon cancer
    Authors: Kelly L. Harris, Stephanie R. Pulliam, Emmanuel Okoro, Zhongmao Guo, Mary K. Washington, Samuel E. Adunyah et al.
    Oncotarget
  116. Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells
    Authors: Y Kato, T Katsuki, H Kokubo, A Masuda, Y Saga
    Nat Commun, 2016-04-13;7(0):11272.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  117. E-cadherin can limit the transforming properties of activating beta-catenin mutations.
    Authors: Huels D, Ridgway R, Radulescu S, Leushacke M, Campbell A, Biswas S, Leedham S, Serra S, Chetty R, Moreaux G, Parry L, Matthews J, Song F, Hedley A, Kalna G, Ceteci F, Reed K, Meniel V, Maguire A, Doyle B, Soderberg O, Barker N, Watson A, Larue L, Clarke A, Sansom O
    EMBO J, 2015-08-03;34(18):2321-33.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  118. Yap and Taz are required for Ret-dependent urinary tract morphogenesis
    Authors: Antoine Reginensi, Masato Hoshi, Sami Kamel Boualia, Maxime Bouchard, Sanjay Jain, Helen McNeill
    Development
  119. Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation
    Authors: Philipp Andre, Hai Song, Wantae Kim, Andreas Kispert, Yingzi Yang
    Development
  120. Genome Editing in Mouse Spermatogonial Stem/Progenitor Cells Using Engineered Nucleases
    Authors: Danielle A. Fanslow, Stacey E. Wirt, Jenny C. Barker, Jon P. Connelly, Matthew H. Porteus, Christina Tenenhaus Dann
    PLoS ONE
  121. Mitogen-activated protein kinase (MAPK) pathway regulates branching by remodeling epithelial cell adhesion.
    Authors: Ihermann-Hella A, Lume M, Miinalainen I, Pirttiniemi A, Gui Y, Peranen J, Charron J, Saarma M, Costantini F, Kuure S
    PLoS Genet, 2014-03-06;10(3):e1004193.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  122. AKT3 regulates ErbB2, ErbB3 and estrogen receptor alpha expression and contributes to endocrine therapy resistance of ErbB2(+) breast tumor cells from Balb-neuT mice.
    Authors: Grabinski N, Mollmann K, Milde-Langosch K, Muller V, Schumacher U, Brandt B, Pantel K, Jucker M
    Cell Signal, 2014-01-24;26(5):1021-9.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  123. Annexin A2 mediates secretion of collagen VI, pulmonary elasticity and apoptosis of bronchial epithelial cells.
    Authors: Dassah M, Almeida D, Hahn R, Bonaldo P, Worgall S, Hajjar K
    J Cell Sci, 2013-12-19;127(0):828-44.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Neutralization
  124. Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis by suppressing IL-17A response: involvement of intestinal epithelial costimulatory molecules.
    Authors: Miyauchi, Eiji, Ogita, Tasuku, Miyamoto, Junki, Kawamoto, Seiji, Morita, Hidetosh, Ohno, Hiroshi, Suzuki, Takuya, Tanabe, Soichi
    PLoS ONE, 2013-11-08;8(11):e79735.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  125. MMP20 modulates cadherin expression in ameloblasts as enamel develops.
    Authors: Guan X, Bartlett J
    2013-09-25;92(0):.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  126. EphrinB2 reverse signaling protects against capillary rarefaction and fibrosis after kidney injury.
    Authors: Kida Y, Ieronimakis N, Schrimpf C, Reyes M, Duffield J
    J Am Soc Nephrol, 2013-03-14;24(4):559-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: IHC
  127. A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis.
    Authors: Neal M, Sodhi C, Dyer M, Craig B, Good M, Jia H, Yazji I, Afrazi A, Richardson W, Beer-Stolz D, Ma C, Prindle T, Grant Z, Branca M, Ozolek J, Hackam D
    J Immunol, 2013-03-01;190(7):3541-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  128. Generation of a germ cell-specific mouse transgenic CHERRY reporter, Sohlh1-mCherryFlag
    Authors: Hitomi Suzuki, Christina Tenenhaus Dann, Aleksandar Rajkovic
    genesis
  129. N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs.
    Biochem Biophys Res Commun, 2012-10-22;428(3):354-9.
    Species: Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: Flow Cytometry, IHC-Fr
  130. Remodeling of the lymphatic vasculature during mouse mammary gland morphogenesis is mediated via epithelial-derived lymphangiogenic stimuli.
    Authors: Betterman K, Paquet-Fifield S, Asselin-Labat M, Visvader J, Butler L, Stacker S, Achen M, Harvey N
    Am J Pathol, 2012-10-11;181(6):2225-38.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  131. Neural crest contribution to lingual mesenchyme, epithelium and developing taste papillae and taste buds
    Authors: Hong-Xiang Liu, Yoshihiro Komatsu, Yuji Mishina, Charlotte M. Mistretta
    Developmental Biology
  132. Epithelial cell-intrinsic notch signaling plays an essential role in the maintenance of gut immune homeostasis.
    Authors: Obata Y, Takahashi D, Ebisawa M, Kakiguchi K, Yonemura S, Jinnohara T, Kanaya T, Fujimura Y, Ohmae M, Hase K, Ohno H
    J. Immunol., 2012-01-25;188(5):2427-36.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  133. Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development
    Authors: Hong-Xiang Liu, Ann S. Grosse, Ken Iwatsuki, Yuji Mishina, Deborah L. Gumucio, Charlotte M. Mistretta
    Developmental Biology
  134. Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism.
    Authors: Wang H, Li Q, Liu J
    PLoS ONE, 2011-09-20;6(9):e24763.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  135. Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors.
    Authors: Nakahara T, Norberg SM, Shalinsky DR, Hu-Lowe DD, McDonald DM
    Cancer Res., 2006-02-01;66(3):1434-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  136. FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons.
    Authors: Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin GR
    Development, 2005-07-27;132(17):3847-57.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  137. Multifunctionality of PAI-1 in fibrogenesis: evidence from obstructive nephropathy in PAI-1-overexpressing mice.
    Authors: Matsuo S, Lopez-Guisa JM, Cai X, Okamura DM, Alpers CE, Bumgarner RE, Peters MA, Zhang G, Eddy AA
    Kidney Int., 2005-06-01;67(6):2221-38.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr, IHC-P
  138. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis.
    Authors: Egan CE, Sodhi CP, Good M et al.
    J. Clin. Invest.
  139. Telophase correction refines division orientation in stratified epithelia
    Authors: KJ Lough, KM Byrd, CP Descovich, DC Spitzer, AJ Bergman, GM Beaudoin, LF Reichardt, SE Williams
    Elife, 2019-12-13;8(0):.
  140. Dental Epithelial Stem Cells as a Source for Mammary Gland Regeneration and Milk Producing Cells In Vivo
    Authors: L Jimenez-Ro, P Pagella, H Harada, TA Mitsiadis
    Cells, 2019-10-22;8(10):.
  141. Recapitulating kidney development in vitro by priming and differentiating mouse embryonic stem cells in monolayers.
    Authors: Chow T, Wong F T M et al.
    NPJ Regen Med
  142. Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells.
    Authors: Nino DF, Sodhi CP, Egan CE et al.
    Shock

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Human/Mouse E-Cadherin Antibody
By Gabriele Strusi on 11/29/2022
Application: WB Sample Tested: HepG2 human hepatocellular carcinoma cell line Species: Human

HepG2 40 ug cell lysate loaded. Aspecific bands appeared at 55 kDa

Western Blot Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Armen Petrosyan on 04/01/2022
Application: IHC Sample Tested: Prostate tissue Species: Human
Immunohistochemistry Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Armen Petrosyan on 04/01/2022
Application: IHC Sample Tested: Mice prostate tissue Species: Mice prostate tissue and Mouse
Immunohistochemistry Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Anonymous on 09/22/2021
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Skin tissue Species: Human
Immunocytochemistry/Immunofluorescence Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Chang Xie on 03/21/2019
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Embryonic lung Species: Mouse
Human/Mouse E-Cadherin Antibody
By Anonymous on 01/14/2019
Application: Immunocytochemistry/Immunofluorescence Sample Tested: RT4-D6P2T rat schwannoma cell line Species: Human
Immunocytochemistry/Immunofluorescence Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Leslie Priddy on 04/13/2018
Application: IHC Sample Tested: Tumor cell lyastes Species: Mouse
Human/Mouse E-Cadherin Antibody
By simon liu on 12/19/2017
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Bladder cancer tissue Species: Human
Immunocytochemistry/Immunofluorescence Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Preethi Vijayaraj on 09/27/2017
Application: Immunocytochemistry/Immunofluorescence Sample Tested: iPSC derived epithelial cells Species: Human
Immunocytochemistry/Immunofluorescence Human/Mouse E-Cadherin Antibody AF748
Human/Mouse E-Cadherin Antibody
By Anonymous on 07/31/2017
Application: WB Sample Tested: 293T human embryonic kidney cell line Species: Human
Human/Mouse E‑Cadherin Antibody
By Anonymous on 04/21/2016
Application: WB Sample Tested: mouse primary brain cell cultures Species: Mouse

Ab concentration: 0.1 ug/ml

Western Blot Human/Mouse E‑Cadherin Antibody AF748