Proteome Profiler Human Apoptosis Array Kit

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors
Authors: Wang, J;Calizo, A;Zhang, L;Pino, JC;Lyu, Y;Pollard, K;Zhang, X;Larsson, AT;Conniff, E;Llosa, NJ;Wood, DK;Largaespada, DA;Moody, SE;Gosline, SJ;Hirbe, AC;Pratilas, CA;
Science advances  2023-11-24

Hydroxyl Group Acetylation of Quercetin Enhances Intracellular Absorption and Persistence to Upregulate Anticancer Activity in HepG2 Cells
Authors: Sakao, K;Saruwatari, H;Minami, S;Hou, DX;
International journal of molecular sciences  2023-11-23

Acquired temozolomide resistance instructs patterns of glioblastoma behavior in gelatin hydrogels
Authors: Kriuchkovskaia, V;Eames, EK;Riggins, RB;Harley, BAC;
bioRxiv : the preprint server for biology  2023-11-16

Simultaneous Inhibition of PI3K and PAK in Preclinical Models of Neurofibromatosis Type 2-related Schwannomatosis
Authors: Fernandez-Valle, C;Nagel, A;Huegel, J;Petrilli, A;Rosario, R;Victoria, B;Hardin, H;
Research square  2023-10-16

In need of age-appropriate cardiac models: Impact of cell age on extracellular matrix therapy outcomes
Authors: Ozcebe, SG;Zorlutuna, P;
Aging cell  2023-10-06

Development, Characterization and Pharmacological Evaluation of Cannabidiol-Loaded Long Circulating Niosomes
Authors: Gugleva, V;Ahchiyska, K;Georgieva, D;Mihaylova, R;Konstantinov, S;Dimitrov, E;Toncheva-Moncheva, N;Rangelov, S;Forys, A;Trzebicka, B;Momekova, D;
Pharmaceutics  2023-10-03

Pyrenebutyrate Pt(IV) Complexes with Nanomolar Anticancer Activity
Authors: Ahmedova, A;Mihaylova, R;Stoykova, S;Mihaylova, V;Burdzhiev, N;Elincheva, V;Momekov, G;Momekova, D;
Pharmaceutics  2023-09-13

Apoptotic effect and cell arrest of deoxyshikonin in human osteosarcoma cells through the p38 pathway
Authors: Hsieh, MC;Hsieh, YH;Chou, CH;Yang, JS;Lu, PW;Huang, TY;Yang, SF;Lu, KH;
Journal of cellular and molecular medicine  2023-05-08

Induction of Apoptosis and Decrease of Autophagy in Colon Cancer Cells by an Extract of Lyophilized Mango Pulp
Authors: GA Lozano-Cas, SS Arango-Var, ME Maldonado-
International Journal of Environmental Research and Public Health, 2023-02-25;20(5):.  2023-02-25

Semilicoisoflavone B Induces Apoptosis of Oral Cancer Cells by Inducing ROS Production and Downregulating MAPK and Ras/Raf/MEK Signaling
Authors: MJ Hsieh, HY Ho, YS Lo, CC Lin, YC Chuang, MM Abomughaid, MC Hsieh, MK Chen
International Journal of Molecular Sciences, 2023-02-24;24(5):.  2023-02-24

CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors
Authors: J Wang, A Calizo, L Zhang, JC Pino, Y Lyu, K Pollard, X Zhang, AT Larsson, E Conniff, N Llosa, DK Wood, DA Largaespad, SE Moody, SJ Gosline, AC Hirbe, CA Pratilas
bioRxiv : the preprint server for biology, 2023-02-03;0(0):.  2023-02-03

ADS024, a Bacillus velezensis strain, protects human colonic epithelial cells against C. difficile toxin-mediated apoptosis
Authors: Y Xie, A Chupina Es, B Nelson, H Feng, C Pothoulaki, L Chesnel, HW Koon
Frontiers in Microbiology, 2023-01-10;13(0):1072534.  2023-01-10

Mycoplasma hominis Causes DNA Damage and Cell Death in Primary Human Keratinocytes
Authors: AT Amorim, VS Lino, LM Marques, DJ Martins, ACR Braga Juni, GB Campos, CNT Oliveira, E Boccardo, J Timenetsky
Microorganisms, 2022-10-01;10(10):.  2022-10-01

Phytochemical analysis of Artemisia kopetdaghensis: Sesquiterpene lactones with proapoptotic activity against prostate cancer cells
Authors: M Fattahian, M Ghanadian, B Zolfaghari, M Aghaei, F Zulfiqar, IA Khan, Z Ali
Phytochemistry, 2022-08-28;203(0):113411.  2022-08-28

Melatonin inhibits NaIO3-induced ARPE-19 cell apoptosis via suppression of HIF-1alpha/BNIP3-LC3B/mitophagy signaling
Authors: K Wang, YS Chen, HW Chien, HL Chiou, SF Yang, YH Hsieh
Cell & bioscience, 2022-08-19;12(1):133.  2022-08-19

Analysis of regulating activities of 5'-epiequisetin on proliferation, apoptosis, and migration of prostate cancer cells in vitro and in vivo
Authors: X Wang, X Luo, X Gan, C Chen, Z Yang, J Wen, W Fang, H Huang, C Gao, X Zhou, X Feng, Y Liu
Frontiers in Pharmacology, 2022-08-10;13(0):920554.  2022-08-10

Depleting TMED3 alleviates the development of endometrial carcinoma
Authors: J Zhang, Y Qi
Cancer Cell International, 2022-07-19;22(1):231.  2022-07-19

Picrasidine I Triggers Heme Oxygenase-1-Induced Apoptosis in Nasopharyngeal Carcinoma Cells via ERK and Akt Signaling Pathways
Authors: HY Ho, PJ Chen, YC Chuang, YS Lo, CC Lin, MJ Hsieh, MK Chen
International Journal of Molecular Sciences, 2022-05-29;23(11):.  2022-05-29

The effect of apigenin and chemotherapy combination treatments on apoptosis-related genes and proteins in acute leukaemia cell lines
Authors: AA Mahbub, CL Le Maitre, NA Cross, N Jordan-Mah
Scientific Reports, 2022-05-25;12(1):8858.  2022-05-25

Design, synthesis, and evaluation of a novel series of mono-indolylbenzoquinones derivatives for the potential treatment of breast cancer
Authors: J Jia, H Yin, C Chen, M Hu, Q Zhong, S Zheng, W Zhang, H Li, L Xu, G Wang, L He
European Journal of Medicinal Chemistry, 2022-04-16;237(0):114375.  2022-04-16

Cell surface nucleolin is a novel ADAMTS5 receptor mediating endothelial cell apoptosis
Authors: DC Kirman, B Renganatha, WK Chui, MW Chen, NA Kaya, R Ge
Cell Death & Disease, 2022-02-23;13(2):172.  2022-02-23

Curcumin analog HO-3867 triggers apoptotic pathways through activating JNK1/2 signalling in human oral squamous cell carcinoma cells
Authors: CW Chen, MJ Hsieh, PC Ju, YH Hsieh, CW Su, YL Chen, SF Yang, CW Lin
Journal of Cellular and Molecular Medicine, 2022-02-21;0(0):.  2022-02-21

Apoptosis-associated speck-like protein containing a CARD regulates the growth of pancreatic ductal adenocarcinoma
Authors: M Koizumi, T Watanabe, J Masumoto, K Sunago, Y Imamura, K Kanemitsu, T Kumagi, Y Hiasa
Scientific Reports, 2021-11-16;11(1):22351.  2021-11-16

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site
Authors: J George, Y Li, IP Kadamberi, D Parashar, SW Tsaih, P Gupta, A Geethadevi, C Chen, C Ghosh, Y Sun, S Mittal, R Ramchandra, H Rui, G Lopez-Bere, C Rodriguez-, G Leone, JS Rader, AK Sood, M Dey, S Pradeep, P Chaluvally
Cell Reports, 2021-11-02;37(5):109934.  2021-11-02

Magnolol Triggers Caspase-Mediated Apoptotic Cell Death in Human Oral Cancer Cells through JNK1/2 and p38 Pathways
Authors: YT Chen, CW Lin, CW Su, WE Yang, CY Chuang, SC Su, MJ Hsieh, SF Yang
Biomedicines, 2021-09-22;9(10):.  2021-09-22

Intravesical Instillation of Azacitidine Suppresses Tumor Formation through TNF-R1 and TRAIL-R2 Signaling in Genotoxic Carcinogen-Induced Bladder Cancer
Authors: SC Wang, YC Chang, MY Wu, CY Yu, SL Chen, WW Sung
Cancers, 2021-08-04;13(16):.  2021-08-04

Alkylaminophenol and GPR17 Agonist for Glioblastoma Therapy: A Combinational Approach for Enhanced Cell Death Activity
Authors: P Doan, P Nguyen, A Murugesan, NR Candeias, O Yli-Harja, M Kandhavelu
Cells, 2021-08-03;10(8):.  2021-08-03

Complement Factor C5a Inhibits Apoptosis of Neutrophils-A Mechanism in Polytrauma?
Authors: C Ehrnthalle, S Braumüller, S Kellermann, F Gebhard, M Perl, M Huber-Lang
Journal of Clinical Medicine, 2021-07-17;10(14):.  2021-07-17

Overexpression of PSMC2 promotes the tumorigenesis and development of human breast cancer via regulating plasminogen activator urokinase (PLAU)
Authors: Y Wang, M Zhu, J Li, Y Xiong, J Wang, H Jing, Y Gu
Cell Death & Disease, 2021-07-09;12(7):690.  2021-07-09

ALPK2 acts as tumor promotor in development of bladder cancer through targeting DEPDC1A
Authors: Y Wang, J Wu, W Luo, H Zhang, G Shi, Y Shen, Y Zhu, C Ma, B Dai, D Ye, Y Zhu
Cell Death & Disease, 2021-07-01;12(7):661.  2021-07-01

Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells
Authors: Z Zhang, M Oh, JI Sasaki, JE Nör
Cell Death & Disease, 2021-06-24;12(7):644.  2021-06-24

Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53
Authors: P Malkomes, I Lunger, E Oppermann, K Abou-El-Ar, T Oellerich, S Günther, C Canbulat, S Bothur, F Schnütgen, W Yu, S Wingert, N Haetscher, C Catapano, MS Dietz, M Heilemann, HM Kvasnicka, K Holzer, H Serve, WO Bechstein, MA Rieger
Oncogene, 2021-06-08;0(0):.  2021-06-08

Long-Term Exposure to Nanosized TiO2 Triggers Stress Responses and Cell Death Pathways in Pulmonary Epithelial Cells
Authors: M Alswady-Ho, JS Erdem, S Phuyal, O Knittelfel, A Sharma, DM Fonseca, Ø Skare, G Slupphaug, S Zienolddin
International Journal of Molecular Sciences, 2021-05-19;22(10):.  2021-05-19

Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells
Authors: L Vania, G Morris, E Ferreira, SFT Weiss
BMC Cancer, 2021-04-09;21(1):392.  2021-04-09

The Antitumor Effects of Plasma-Activated Saline on Muscle-Invasive Bladder Cancer Cells In Vitro and In Vivo Demonstrate Its Feasibility as a Potential Therapeutic Approach
Authors: H Zhang, J Zhang, B Guo, H Chen, D Xu, MG Kong
Cancers, 2021-03-02;13(5):.  2021-03-02

TGF-&beta1 signaling inhibit the in vitro apoptotic, infection and stimulatory cell response induced by influenza H1N1 virus infection on A549 cells
Authors: GB Rivera-Bah, AH Márquez-Ba, DV López-Guer, FR Esquivel-G, JL Montiel-He
Virus research, 2021-02-10;0(0):198337.  2021-02-10

Luteolin inhibits proliferation, triggers apoptosis and modulates Akt/mTOR and MAP kinase pathways in HeLa cells
Authors: R Raina, S Pramodh, N Rais, S Haque, J Shafarin, K Bajbouj, M Hamad, A Hussain
Oncology Letters, 2021-01-07;21(3):192.  2021-01-07

Carbon ion triggered immunogenic necroptosis of nasopharyngeal carcinoma cells involving necroptotic inhibitor BCL-x
Authors: C Bao, Y Sun, B Dwarakanat, Y Dong, Y Huang, X Wu, C Guha, L Kong, JJ Lu
Journal of Cancer, 2021-01-01;12(5):1520-1530.  2021-01-01

Activation of the miR-371/372/373 miRNA Cluster Enhances Oncogenicity and Drug Resistance in Oral Carcinoma Cells
Authors: SC Lin, HL Wu, LY Yeh, CC Yang, SY Kao, KW Chang
International Journal of Molecular Sciences, 2020-12-11;21(24):.  2020-12-11

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer
Authors: H Khawaja, A Campbell, JZ Roberts, A Javadi, P O'Reilly, D McArt, WL Allen, J Majkut, M Rehm, A Bardelli, F Di Nicolan, CJ Scott, R Kennedy, N Vitale, T Harrison, OJ Sansom, DB Longley, E Evergren, S Van Schaey
Cell Death Dis, 2020-10-29;11(10):930.  2020-10-29

CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer
Authors: JC Fleming, J Woo, K Moutasim, CJ Hanley, SJ Frampton, O Wood, M Ward, CH Woelk, CH Ottensmeie, S Hafizi, D Kim, GJ Thomas
Cancers (Basel), 2020-10-13;12(10):.  2020-10-13

Selinexor Sensitizes TRAIL-R2-Positive TNBC Cells to the Activity of TRAIL-R2xCD3 Bispecific Antibody
Authors: S Martini, M Figini, A Croce, B Frigerio, M Pennati, AM Gianni, C De Marco, MG Daidone, C Argueta, Y Landesman, N Zaffaroni, A Satta
Cells, 2020-10-02;9(10):.  2020-10-02

Decreased Thymic Output Contributes to Immune Defects in Septic Patients
Authors: N Sommer, S Noack, A Hecker, H Hackstein, G Bein, N Weissmann, W Seeger, K Mayer, M Hecker
J Clin Med, 2020-08-20;9(9):.  2020-08-20

Punicalagin Regulates Apoptosis-Autophagy Switch via Modulation of Annexin A1 in Colorectal Cancer
Authors: T Ganesan, A Sinniah, Z Chik, MA Alshawsh
Nutrients, 2020-08-13;12(8):.  2020-08-13

Robustaflavone induces G0/G1 cell cycle arrest and apoptosis in human umbilical vein endothelial cells and exhibits anti-angiogenic effects in vivo
Authors: WK Sim, JH Park, KY Kim, IS Chung
Sci Rep, 2020-07-06;10(1):11070.  2020-07-06

Sequesterpene Lactones Isolated from a Brazilian Cerrado Plant (Eremanthus spp.) as Anti-Proliferative Compounds, Characterized by Functional and Proteomic Analysis, are Candidates for New Therapeutics in Glioblastoma
Authors: C Izumi, HJ Laure, NG Barbosa, C Hassibe Th, G Aguiar Fer, J Paulo Barr, N Peporine L, J César Rosa
Int J Mol Sci, 2020-07-01;21(13):.  2020-07-01

Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis
Authors: A Ianevski, E Kulesskiy, K Krpina, G Lou, Y Aman, A Bugai, K Aasumets, Y Akimov, D Bulanova, K Gildemann, AF Arutyunyan, OY Susova, AL Zhuze, P Ji, W Wang, T Holien, M Bugge, E Zusinaite, V Oksenych, H Lysvand, JM Gerhold, M Bjørås, P Johansen, A Waage, CA Heckman, EF Fang, DE Kainov
Cancers (Basel), 2020-06-25;12(6):.  2020-06-25

Antiproliferative and Apoptotic Effects of Cardamonin against Hepatocellular Carcinoma HepG2 Cells
Authors: NA Badroon, N Abdul Maji, MA Alshawsh
Nutrients, 2020-06-12;12(6):.  2020-06-12

TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades
Authors: SA Scarneo, KW Yang, JR Roques, A Dai, LS Eibschutz, P Hughes, TAJ Haystead
Oncotarget, 2020-05-26;11(21):1961-1970.  2020-05-26

Two Sides to the Same Coin-Cytotoxicity vs. Potential Metastatic Activity of AgNPs Relative to Triple-Negative Human Breast Cancer MDA-MB-436 Cells
Authors: M Matysiak-K, M Czajka, B Jod?owska-, K Sawicki, P Wojty?a-Bu, M Kruszewski, L Kapka-Skrz
Molecules, 2020-05-20;25(10):.  2020-05-20

Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma
Authors: J Lippmann, K Petri, S Fulda, J Liese
Transl Oncol, 2020-05-13;13(8):100785.  2020-05-13

The Effect of 4'-hydroxy-3,4,5-trimetoxystilbene, the Metabolite of Resveratrol Analogue DMU-212, on Growth, Cell Cycle and Apoptosis in DLD-1 and LOVO Colon Cancer Cell Lines
Authors: M Jozkowiak, P Skupin-Mru, A Nowicki, S Borys-Wojc, M Wierzchows, M Kaczmarek, P Ramlau, J Jodynis-Li, H Piotrowska
Nutrients, 2020-05-07;12(5):.  2020-05-07

Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction
Authors: DJ Trembinski, DI Bink, K Theodorou, J Sommer, A Fischer, A van Bergen, CC Kuo, IG Costa, C Schürmann, MS Leisegang, RP Brandes, T Alekseeva, B Brill, A Wietelmann, CN Johnson, A Spring-Con, M Kaulich, S Werfel, S Engelhardt, MN Hirt, K Yorgan, T Eschenhage, L Kirchhof, P Hofmann, N Jaé, I Wittig, N Hamdani, C Bischof, J Krishnan, RH Houtkooper, S Dimmeler, RA Boon
Nat Commun, 2020-04-27;11(1):2039.  2020-04-27

Identification of UAP1L1 as tumor promotor in gastric cancer through regulation of CDK6
Authors: J Qi, S Liu, W Liu, G Cai, G Liao
Aging (Albany NY), 2020-04-20;12(8):6904-6927.  2020-04-20

Apoptosis characterization in mononuclear blood leukocytes of HIV�patients during dengue acute disease
Authors: A Torrentes-, JC Sánchez-Ar, T Azamor, LS Barbosa, ED Hottz, M Gandini, FA Bozza, RV da Cunha, LM de Oliveir, PV Damasco, EL de Azeredo
Sci Rep, 2020-04-14;10(1):6351.  2020-04-14

Dual Targeting of the p38 MAPK-HO-1 Axis and cIAP1/XIAP by Demethoxycurcumin Triggers Caspase-Mediated Apoptotic Cell Death in Oral Squamous Cell Carcinoma Cells
Authors: MH Chien, WE Yang, YC Yang, CC Ku, WJ Lee, MY Tsai, CW Lin, SF Yang
Cancers (Basel), 2020-03-16;12(3):.  2020-03-16

Apoptosis Induced by (-)-Epicatechin in Human Breast Cancer Cells is Mediated by Reactive Oxygen Species
Authors: F Pereyra-Ve, IM Olivares-C, AG Perez-Ruiz, JP Luna-Arias, JR García-Sán
Molecules, 2020-02-25;25(5):.  2020-02-25

The TUSC2 Tumour Suppressor Inhibits the Malignant Phenotype of Human Thyroid Cancer Cells via SMAC/DIABLO Protein
Authors: RM Mariniello, FM Orlandella, AE Stefano, PLC Iervolino, G Smaldone, N Luciano, N Cervone, F Munciguerr, S Esposito, P Mirabelli, G Salvatore
Int J Mol Sci, 2020-01-21;21(3):.  2020-01-21

PLF-1 (Proliferin-1) Modulates Smooth Muscle Cell Proliferation and Development of Experimental Intimal Hyperplasia
Authors: L Hu, Z Huang, H Ishii, H Wu, S Suzuki, A Inoue, W Kim, H Jiang, X Li, E Zhu, L Piao, G Zhao, Y Lei, K Okumura, GP Shi, T Murohara, M Kuzuya, XW Cheng
J Am Heart Assoc, 2019-12-16;8(24):e005886.  2019-12-16

Semi-Synthetic Ingenol Derivative from Euphorbia tirucalli Inhibits Protein Kinase C Isotypes and Promotes Autophagy and S-phase Arrest on Glioma Cell Lines
Authors: VAO Silva, MN Rosa, A Tansini, O Martinho, A Tanuri, AF Evangelist, A Cruvinel C, JP Lima, LF Pianowski, RM Reis
Molecules, 2019-11-22;24(23):.  2019-11-22

Modeling Snyder-Robinson Syndrome in multipotent stromal cells reveals impaired mitochondrial function as a potential cause for deficient osteogenesis
Authors: AL Ramsay, V Alonso-Gar, C Chaboya, B Radut, B Le, J Florez, C Schumacher, FA Fierro
Sci Rep, 2019-10-28;9(1):15395.  2019-10-28

Protein Expression Profiling Identifies Key Proteins and Pathways Involved in Growth Inhibitory Effects Exerted by Guggulsterone in Human Colorectal Cancer Cells
Authors: R Leo, L Therachiyi, SK Siveen, S Uddin, M Kulinski, J Buddenkott, M Steinhoff, AR Krishnanku
Cancers (Basel), 2019-10-01;11(10):.  2019-10-01

Tissue-regenerative potential of the secretome of gamma-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis
Authors: E Simader, L Beer, M Laggner, V Vorstandle, A Gugerell, M Erb, P Kalinina, D Copic, D Moser, A Spittler, E Tschachler, H Jan Ankers, M Mildner
Cell Death Dis, 2019-09-30;10(10):729.  2019-09-30

CLEFMA Activates the Extrinsic and Intrinsic Apoptotic Processes through JNK1/2 and p38 Pathways in Human Osteosarcoma Cells
Authors: JS Yang, RC Lin, YH Hsieh, HH Wu, GC Li, YC Lin, SF Yang, KH Lu
Molecules, 2019-09-09;24(18):.  2019-09-09

Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1
Authors: TND Pham, S Stempel, MA Shields, C Spaulding, K Kumar, DJ Bentrem, M Matsangou, HG Munshi
Int J Mol Sci, 2019-09-02;20(17):.  2019-09-02

Effective Treatment of Metastatic Melanoma by Combining MAPK and PI3K Signaling Pathway Inhibitors
Authors: SN Aasen, H Parajuli, T Hoang, Z Feng, K Stokke, J Wang, K Roy, R Bjerkvig, S Knappskog, F Thorsen
Int J Mol Sci, 2019-08-29;20(17):.  2019-08-29

Kinome expression profiling to target new therapeutic avenues in multiple myeloma
Authors: H de Boussac, A Bruyer, M Jourdan, A Maes, N Robert, C Gourzones, L Vincent, A Seckinger, G Cartron, D Hose, E De Bruyne, A Kassambara, P Pasero, J Moreaux
Haematologica, 2019-07-09;0(0):.  2019-07-09

Comparison of Radiosensitization by HDAC Inhibitors CUDC-101 and SAHA in Pancreatic Cancer Cells
Authors: S Moertl, S Payer, R Kell, K Winkler, N Anastasov, MJ Atkinson
Int J Mol Sci, 2019-07-02;20(13):.  2019-07-02

A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH
Authors: M Ueda, M Okada, M Mizuguchi, B Kluve-Beck, K Kanenawa, A Isoguchi, Y Misumi, M Tasaki, A Ueda, A Kanai, R Sasaki, T Masuda, Y Inoue, T Nomura, S Shinriki, T Shuto, H Kai, T Yamashita, H Matsui, MD Benson, Y Ando
J. Biol. Chem., 2019-06-05;0(0):.  2019-06-05

Heme Oxygenase-1 is a Key Molecule Underlying Differential Response of TW-37-Induced Apoptosis in Human Mucoepidermoid Carcinoma Cells
Authors: IH Yang, CH Ahn, NP Cho, B Jin, W Lee, YC Jung, SD Hong, JA Shin, SD Cho
Molecules, 2019-05-01;24(9):.  2019-05-01

Investigation into the Molecular Mechanisms underlying the Anti-proliferative and Anti-tumorigenesis activities of Diosmetin against HCT-116 Human Colorectal Cancer
Authors: S Koosha, Z Mohamed, A Sinniah, MA Alshawsh
Sci Rep, 2019-03-26;9(1):5148.  2019-03-26

Cytarabine-Resistant FLT3-ITD Leukemia Cells are Associated with TP53 Mutation and Multiple Pathway Alterations-Possible Therapeutic Efficacy of Cabozantinib
Authors: YC Ko, CY Hu, ZH Liu, HF Tien, DL Ou, HF Chien, LI Lin
Int J Mol Sci, 2019-03-11;20(5):.  2019-03-11

Reverse signaling via PD-L1 supports malignant cell growth and survival in classical Hodgkin lymphoma
Authors: S Jalali, T Price-Tros, C Bothun, J Villasboas, HJ Kim, ZZ Yang, AJ Novak, H Dong, SM Ansell
Blood Cancer J, 2019-02-19;9(3):22.  2019-02-19

Mechanisms of Toxicity of Industrially Relevant Silicomanganese Dust on Human 1321N1 Astrocytoma Cells: An In Vitro Study
Authors: YJ Arnoldusse, T Kringlen E, J Samulin Er, I Kero, M Baarnes Er, V Skaug, S Zienolddin
Int J Mol Sci, 2019-02-10;20(3):.  2019-02-10

In vitro cytotoxicity and anticancer effects of citral nanostructured lipid carrier on MDA MBA-231 human breast cancer cells
Authors: N Nordin, SK Yeap, HS Rahman, NR Zamberi, N Abu, NE Mohamad, CW How, MJ Masarudin, R Abdullah, NB Alitheen
Sci Rep, 2019-02-07;9(1):1614.  2019-02-07

Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis
Authors: NA Razak, N Abu, WY Ho, NR Zamberi, SW Tan, NB Alitheen, K Long, SK Yeap
Sci Rep, 2019-02-06;9(1):1514.  2019-02-06

Natural product inspired allicin analogs as novel anti-cancer agents
Authors: I Bhaumik, K Pal, U Debnath, P Karmakar, K Jana, AK Misra
Bioorg. Chem., 2019-01-29;86(0):259-272.  2019-01-29

Muscadine grape skin extract inhibits prostate cancer cells by inducing cell-cycle arrest, and decreasing migration through heat shock protein 40
Authors: DN Ignacio, KD Mason, EC Hackett-Mo, C Albanese, L Ringer, WD Wagner, PC Wang, MA Carducci, SK Kachhap, CJ Paller, J Mendonca, L Li-Ying Ch, B Lin, DK Hartle, JE Green, CA Brown, TS Hudson
Heliyon, 2019-01-16;5(1):e01128.  2019-01-16

HPV-Mediated Resistance to TNF and TRAIL Is Characterized by Global Alterations in Apoptosis Regulatory Factors, Dysregulation of Death Receptors, and Induction of ROS/RNS
Authors: TK Cabeça, A de Mello A, R Andrette, V de Souza L, MG Morale, F Aguayo, L Termini, LL Villa, AP Lepique, E Boccardo
Int J Mol Sci, 2019-01-08;20(1):.  2019-01-08

KRas4B-PDE6? complex stabilization by small molecules obtained by virtual screening affects Ras signaling in pancreatic cancer
Authors: D Casique-Ag, P Briseño-Dí, P García-Gut, CHG la Rosa, RS Quintero-B, A Rojo-Domín, I Vergara, LA Medina, J Correa-Bas, M Bello, R Hernández-, M Del RocioT, M Vargas
BMC Cancer, 2018-12-29;18(1):1299.  2018-12-29

6- and 8-Prenylnaringenin, Novel Natural Histone Deacetylase Inhibitors Found in Hops, Exert Antitumor Activity on Melanoma Cells
Authors: S Venturelli, H Niessner, T Sinnberg, A Berger, M Burkard, C Urmann, K Donaubauer, A Böcker, C Leischner, H Riepl, J Frank, UM Lauer, C Garbe, C Busch
Cell. Physiol. Biochem., 2018-11-20;51(2):543-556.  2018-11-20

Targeting PDK4 inhibits breast cancer metabolism
Authors: MR Guda, S Asuthkar, CM Labak, AJ Tsung, I Alexandrov, MJ Mackenzie, DV Prasad, KK Velpula
Am J Cancer Res, 2018-09-01;8(9):1725-1738.  2018-09-01

Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma
Authors: D Xu, SQ Liang, H Yang, U Lüthi, C Riether, S Berezowska, TM Marti, SRR Hall, R Bruggmann, GJ Kocher, RA Schmid, RW Peng
Br. J. Cancer, 2018-06-20;0(0):.  2018-06-20

Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
Authors: B Haas, V Klinger, C Keksel, V Bonigut, D Kiefer, J Caspers, J Walther, M Wos-Magang, S Weickhardt, G Röhn, M Timmer, R Frötschl, N Eckstein
Cancer Cell Int., 2018-05-04;18(0):69.  2018-05-04

DK1 Induces Apoptosis via Mitochondria-Dependent Signaling Pathway in Human Colon Carcinoma Cell Lines In Vitro
Authors: Y Hussin, MNM Aziz, NF Che Rahim, SK Yeap, NE Mohamad, MJ Masarudin, N Nordin, NMA Abd Rahman, CY Yong, MN Akhtar, SNH Zamrus, NB Alitheen
Int J Mol Sci, 2018-04-11;19(4):.  2018-04-11

Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide
Authors: SS Kim, JB Harford, M Moghe, A Rait, KF Pirollo, EH Chang
Nucleic Acids Res., 2018-02-16;0(0):.  2018-02-16

Induction of apoptosis by pinostrobin in human cervical cancer cells: Possible mechanism of action
Authors: A Jaudan, S Sharma, SNA Malek, A Dixit
PLoS ONE, 2018-02-08;13(2):e0191523.  2018-02-08

Diverse functions of clusterin promote and protect against the development of pulmonary fibrosis
Authors: L Peix, IC Evans, DR Pearce, JK Simpson, TM Maher, RJ McAnulty
Sci Rep, 2018-01-30;8(1):1906.  2018-01-30

Curcumin Analog DK1 Induces Apoptosis in Human Osteosarcoma Cells In Vitro through Mitochondria-Dependent Signaling Pathway
Authors: MNM Aziz, Y Hussin, NF Che Rahim, N Nordin, NE Mohamad, SK Yeap, CY Yong, MJ Masarudin, YK Cheah, N Abu, MN Akhtar, NB Alitheen
Molecules, 2018-01-05;23(1):.  2018-01-05

Transcriptome Analysis of Gene Expression Provides New Insights into the Effect of Mild Therapeutic Hypothermia on Primary Human Cortical Astrocytes Cultured under Hypoxia
Authors: MM Salman, P Kitchen, MN Woodroofe, RM Bill, AC Conner, PR Heath, MT Conner
Front Cell Neurosci, 2017-12-14;11(0):386.  2017-12-14

Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling
Authors: R Johnson, S Shabalala, J Louw, AP Kappo, CJF Muller
Molecules, 2017-09-22;22(10):.  2017-09-22

Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest
Authors: K Oura, T Tadokoro, S Fujihara, A Morishita, T Chiyo, E Samukawa, Y Yamana, K Fujita, T Sakamoto, T Nomura, H Yoneyama, H Kobara, H Mori, H Iwama, K Okano, Y Suzuki, T Masaki
Oncol. Rep., 2017-09-20;38(5):2825-2835.  2017-09-20

The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
Authors: IC Etti, R Abdullah, A Kadir, NM Hashim, SK Yeap, MU Imam, F Ramli, I Malami, KL Lam, U Etti, P Waziri, M Rahman
PLoS ONE, 2017-08-03;12(8):e0182357.  2017-08-03

WWOX sensitises ovarian cancer cells to paclitaxel via modulation of the ER stress response
Authors: S Janczar, J Nautiyal, Y Xiao, E Curry, M Sun, E Zanini, AJ Paige, H Gabra
Cell Death Dis, 2017-07-27;8(7):e2955.  2017-07-27

Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival
Authors: RJ Chen, CT Shun, ML Yen, CH Chou, MC Lin
Oncotarget, 2017-07-07;8(37):62081-62098.  2017-07-07

Dual Inhibition of HDAC and tyrosine kinase signaling pathways with CUDC-907 inhibits thyroid cancer growth and metastases
Authors: S Kotian, L Zhang, M Boufraqech, K Gaskins, SK Gara, MM Quezado, N Nilubol, E Kebebew
Clin. Cancer Res., 2017-06-09;0(0):.  2017-06-09

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes
Authors: M Mustapic, E Eitan, JK Werner, ST Berkowitz, MP Lazaropoul, J Tran, EJ Goetzl, D Kapogianni
Front Neurosci, 2017-05-22;11(0):278.  2017-05-22

Discovery of a novel small molecule inhibitor that targets PP2A-?-Catenin signaling and restricts tumor growth and metastasis
Authors: S Maheshwari, AS Rao, A Singh, LR Singh, GR Palnati, RK Arya, SH Cheruvu, S Shahi, T Sharma, S Meena, AK Singh, R Kant, M Riyazuddin, HK Bora, MI Siddiqi, JR Gayen, KV Sashidhara, D Datta
Mol. Cancer Ther., 2017-05-12;0(0):.  2017-05-12

Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell
Authors: S Chen, J Tao, F Zhong, Y Jiao, J Xu, Q Shen, H Wang, S Fan, Y Zhang
PLoS ONE, 2017-05-03;12(5):e0176501.  2017-05-03

MCPIP1 Exogenous Overexpression Inhibits Pathways Regulating MYCN Oncoprotein Stability in Neuroblastoma
Authors: El?bieta Boratyn
J. Cell. Biochem, 2017-03-27;0(0):.  2017-03-27

Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
Authors: IC Etti, A Rasedee, NM Hashim, AB Abdul, A Kadir, SK Yeap, P Waziri, I Malami, KL Lim, CJ Etti
Drug Des Devel Ther, 2017-03-20;11(0):865-879.  2017-03-20

MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis
Authors: CS Mak, MM Yung, LM Hui, LL Leung, R Liang, K Chen, SS Liu, Y Qin, TH Leung, KF Lee, KK Chan, HY Ngan, DW Chan
Mol. Cancer, 2017-01-17;16(1):11.  2017-01-17

Differential effects of Helenalin, an anti-inflammatory sesquiterpene lactone, on the proteome, metabolome and the oxidative stress response in several immune cell types
Authors: Paula Zwicker
Toxicol In Vitro, 2016-12-18;40(0):45-54.  2016-12-18

Enhancing radiosensitization in EphB4 receptor-expressing Head and Neck Squamous Cell Carcinomas
Sci Rep, 2016-12-12;6(0):38792.  2016-12-12

Large-scale pharmacological profiling of 3D tumor models of cancer cells
Cell Death Dis, 2016-12-01;7(12):e2492.  2016-12-01

SurR9C84A Protects and Recovers Human Cardiomyocytes from Hypoxia Induced Apoptosis
Authors: Rupinder Kaur Kanwar
Exp. Cell Res., 2016-11-02;0(0):.  2016-11-02

Suppression of mir-200 family expression by oncogenic KRAS activation promotes cell survival and epithelial-mesenchymal transition in KRAS-driven cancer
Mol Cell Biol, 2016-10-13;0(0):.  2016-10-13

Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma
PLoS ONE, 2016-09-02;11(9):e0159749.  2016-09-02

Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment
PLoS ONE, 2016-07-08;11(7):e0159013.  2016-07-08

Synergistic effects of combined treatment with histone deacetylase inhibitor suberoylanilide hydroxamic acid and TRAIL on human breast cancer cells
Authors: Weiqiang Zhou
Sci Rep, 2016-06-13;6(0):28004.  2016-06-13

Cisplatin-induced mesenchymal stromal cells-mediated mechanism contributing to decreased antitumor effect in breast cancer cells.
Authors: Skolekova S, Matuskova M, Bohac M, Toro L, Demkova L, Gursky J, Kucerova L
Cell Commun Signal, 2016-01-12;14(1):4.  2016-01-12

GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway.
Authors: Mahata B, Biswas S, Rayman P, Chahlavi A, Ko J, Bhattacharjee A, Li Y, Li Y, Das T, Sa G, Raychaudhuri B, Vogelbaum M, Tannenbaum C, Finke J, Biswas K
PLoS ONE, 2015-07-30;10(7):e0134425.  2015-07-30

EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer.
Authors: Subramanian N, Kanwar J, Kanwar R, Sreemanthula J, Biswas J, Khetan V, Krishnakumar S
PLoS ONE, 2015-07-15;10(7):e0132407.  2015-07-15

Inhibition of Survivin with YM155 Induces Durable Tumor Response in Anaplastic Thyroid Cancer.
Authors: Mehta A, Zhang L, Boufraqech M, Liu-Chittenden Y, Zhang Y, Patel D, Davis S, Rosenberg A, Ylaya K, Aufforth R, Li Z, Shen M, Kebebew E
Clin Cancer Res, 2015-05-05;21(18):4123-32.  2015-05-05

Antineoplastic Effects of siRNA against TMPRSS2-ERG Junction Oncogene in Prostate Cancer.
Authors: Urbinati G, Ali H, Rousseau Q, Chapuis H, Desmaele D, Couvreur P, Massaad-Massade L
PLoS ONE, 2015-05-01;10(5):e0125277.  2015-05-01

AMP-18 Targets p21 to Maintain Epithelial Homeostasis.
Authors: Chen P, Li Y, Toback F
PLoS ONE, 2015-04-28;10(4):e0125490.  2015-04-28

Decidualization and syndecan-1 knock down sensitize endometrial stromal cells to apoptosis induced by embryonic stimuli.
Authors: Boeddeker S, Baston-Buest D, Fehm T, Kruessel J, Hess A
PLoS ONE, 2015-04-01;10(4):e0121103.  2015-04-01

Decreased expression of APAF-1 and increased expression of cathepsin B in invasive pituitary adenoma.
Authors: Tanase, Cristian, Albulescu, Radu, Codrici, Elena, Calenic, Bogdan, Popescu, Ionela D, Mihai, Simona, Necula, Laura, Cruceru, Maria Li, Hinescu, Mihail E
Onco Targets Ther, 2014-12-22;8(0):81-90.  2014-12-22

High dose ionizing radiation regulates micro RNA and gene expression changes in human peripheral blood mononuclear cells.
Authors: Beer L, Seemann R, Ristl R, Ellinger A, Kasiri M, Mitterbauer A, Zimmermann M, Gabriel C, Gyongyosi M, Klepetko W, Mildner M, Ankersmit H
BMC Genomics, 2014-09-25;15(0):814.  2014-09-25

ABCB5 is a limbal stem cell gene required for corneal development and repair.
Authors: Ksander B, Kolovou P, Wilson B, Saab K, Guo Q, Ma J, McGuire S, Gregory M, Vincent W, Perez V, Cruz-Guilloty F, Kao W, Call M, Tucker B, Zhan Q, Murphy G, Lathrop K, Alt C, Mortensen L, Lin C, Zieske J, Frank M, Frank N
Nature, 2014-07-02;511(7509):353-7.  2014-07-02

B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection.
Authors: Nothelfer K, Arena E, Pinaud L, Neunlist M, Mozeleski B, Belotserkovsky I, Parsot C, Dinadayala P, Burger-Kentischer A, Raqib R, Sansonetti P, Phalipon A
J Exp Med, 2014-05-26;211(6):1215-29.  2014-05-26

MicroRNA-155 as an inducer of apoptosis and cell differentiation in Acute Myeloid Leukaemia.
Authors: Palma, Catalina, Al Sheikha, Dima, Lim, Teck Kha, Bryant, Adam, Vu, Thi Than, Jayaswal, Vivek, Ma, David D
Mol Cancer, 2014-04-05;13(0):79.  2014-04-05

Aldose reductase-mediated phosphorylation of p53 leads to mitochondrial dysfunction and damage in diabetic platelets.
Authors: Tang, Wai Ho, Stitham, Jeremiah, Jin, Yu, Liu, Renjing, Lee, Seung He, Du, Jing, Atteya, Gourg, Gleim, Scott, Spollett, Geralyn, Martin, Kathleen, Hwa, John
Circulation, 2014-01-28;129(15):1598-609.  2014-01-28

Targeting cadherin-17 inactivates Ras/Raf/MEK/ERK signaling and inhibits cell proliferation in gastric cancer.
Authors: Lin Z, Zhang C, Zhang M, Xu D, Fang Y, Zhou Z, Chen X, Qin N, Zhang X
PLoS ONE, 2014-01-20;9(1):e85296.  2014-01-20

Vertical blockade of the IGFR- PI3K/Akt/mTOR pathway for the treatment of hepatocellular carcinoma: the role of survivin.
Authors: Ou, Da-Liang, Lee, Bin-Shyu, Lin, Liang-In, Liou, Jun-Yang, Liao, Sheng-Ch, Hsu, Chiun, Cheng, Ann-Lii
Mol Cancer, 2014-01-03;13(0):2.  2014-01-03

How liposomal Cisplatin overcomes chemoresistance in ovarian tumour cells.
Anticancer Res, 2014-01-01;34(1):525-30.  2014-01-01

Cold atmospheric plasma (CAP) changes gene expression of key molecules of the wound healing machinery and improves wound healing in vitro and in vivo.
Authors: Arndt S, Unger P, Wacker E, Shimizu T, Heinlin J, Li Y, Thomas H, Morfill G, Zimmermann J, Bosserhoff A, Karrer S
PLoS ONE, 2013-11-12;8(11):e79325.  2013-11-12

Cidofovir: a novel antitumor agent for glioblastoma.
Authors: Hadaczek P, Ozawa T, Soroceanu L, Yoshida Y, Matlaf L, Singer E, Fiallos E, James C, Cobbs C
Clin Cancer Res, 2013-10-29;19(23):6473-83.  2013-10-29

Targeting ovarian cancer and chemoresistance through selective inhibition of sphingosine kinase-2 with ABC294640.
Authors: White, Martin D, Chan, Lucas, Antoon, James W, Beckman, Barbara
Anticancer Res, 2013-09-01;33(9):3573-9.  2013-09-01

The novel c-Met inhibitor cabozantinib overcomes gemcitabine resistance and stem cell signaling in pancreatic cancer.
Authors: Hage C, Rausch V, Giese N, Giese T, Schonsiegel F, Labsch S, Nwaeburu C, Mattern J, Gladkich J, Herr I
Cell Death Dis, 2013-05-09;4(0):e627.  2013-05-09

NFATc2 is a potential therapeutic target in human melanoma.
J. Invest. Dermatol., 2012-06-21;132(11):2652-60.  2012-06-21

Locally different endothelial nitric oxide synthase protein levels in ascending aortic aneurysms of bicuspid and tricuspid aortic valve.
Authors: Mohamed SA, Radtke A, Saraei R
Cardiol Res Pract, 2012-06-18;2012(0):165957.  2012-06-18

Cacospongionolide and scalaradial, two marine sesterterpenoids as potent apoptosis-inducing factors in human carcinoma cell lines.
Authors: De Stefano D, Tommonaro G, Malik SA, Iodice C, De Rosa S, Maiuri MC, Carnuccio R
PLoS ONE, 2012-04-03;7(4):e33031.  2012-04-03

TWEAK affects keratinocyte G2/M growth arrest and induces apoptosis through the translocation of the AIF protein to the nucleus.
Authors: Sabour Alaoui S, Dessirier V, de Araujo E, Alexaki VI, Pelekanou V, Lkhider M, Stathopoulos EN, Castanas E, Bagot M, Bensussan A, Tsapis A
PLoS ONE, 2012-03-16;7(3):e33609.  2012-03-16

Antiapoptotic signaling via MCL1 confers resistance to caspase-3-mediated apoptotic cell death in the pregnant human uterine myocyte.
Authors: Stephenson-Famy A, Marks J, Suresh A
Mol. Endocrinol., 2011-12-22;26(2):320-30.  2011-12-22

Anti-tumor effects of fibroblast growth factor-binding protein (FGF-BP) knockdown in colon carcinoma.
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Mol. Cancer, 2011-11-23;10(0):144.  2011-11-23

Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
Authors: Li J, Cho YY, Langfald A
Cancer Prev Res (Phila), 2011-07-26;4(8):1190-7.  2011-07-26

LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma.
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Oncogene, 2010-12-06;30(15):1753-63.  2010-12-06

CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1.
Authors: Datta D, Banerjee P, Gasser M
J. Biol. Chem., 2010-09-20;285(47):36842-8.  2010-09-20

Inhibition of caspase-3 differentially affects vascular smooth muscle cell apoptosis in the concave versus convex aortic sites in ascending aneurysms with a bicuspid aortic valve.
Authors: Mohamed SA, Misfeld M, Hanke T, Charitos EI, Bullerdiek J, Belge G, Kuehnel W, Sievers HH
Ann. Anat., 2010-04-11;192(3):145-50.  2010-04-11

Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis.
Authors: Ray RB, Raychoudhuri A, Steele R
Cancer Res., 2010-02-23;70(5):1925-31.  2010-02-23

A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
Authors: Cailleteau C, Liagre B, Beneytout JL
J. Cell. Biochem., 2009-07-01;107(4):785-96.  2009-07-01