Proteome Profiler Human Phospho-RTK Array Kit

ARL6IP5 Ameliorates alpha -Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12
Authors: Siddique, I;Kamble, K;Gupta, S;Solanki, K;Bhola, S;Ahsan, N;Gupta, S;
International journal of molecular sciences  2023-06-22

Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
Authors: Kim, S;Carvajal, R;Kim, M;Yang, HW;
Cell reports  2023-05-29

Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling
Authors: Pillay, V;Shukla, L;Herle, P;Maciburko, S;Bandara, N;Reid, I;Morgan, S;Yuan, Y;Luu, J;Cowley, KJ;Ramm, S;Simpson, KJ;Achen, MG;Stacker, SA;Shayan, R;Karnezis, T;
Frontiers in pharmacology  2023-04-28

Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities
Authors: I Paassen, J Williams, C Ríos Arceo, F Ringnalda, KS Mercer, JL Buhl, N Moreno, A Federico, NE Franke, M Kranendonk, SA Upadhyaya, K Kerl, M van de Wet, H Clevers, M Kool, EW Hoving, MF Roussel, J Drost
Oncogene, 2023-04-05;0(0):.  2023-04-05

Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema
Authors: JJ Park, K Oh, GW Lee, G Bang, JH Park, HB Kim, JY Kim, EY Shin, EG Kim
Experimental & Molecular Medicine, 2023-04-03;0(0):.  2023-04-03

Redundant Signaling as the Predominant mechanism for Resistance to Antibodies Targeting IGF-1R in Cells Derived from Childhood Sarcoma
Authors: TJ Shacklefor, S Hariharan, AV Vaseva, K Alagoa, M Espinoza, HK Bid, F Li, H Zhong, DA Phelps, RD Roberts, H Cam, CA London, DC Guttridge, Y Chen, M Rao, Y Shiio, PJ Houghton
Molecular Cancer Therapeutics, 2023-04-03;0(0):.  2023-04-03

Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors
Authors: R Tiedt, FJ King, C Stamm, MJ Niederst, S Delach, S Zumstein-M, J Meltzer, IJ Mulford, E Labrot, BS Engstler, S Baltschuka, G Kerr, J Golji, D Wyss, C Schnell, E Ainscow, JA Engelman, WR Sellers, J Barretina, G Caponigro, DG Porta
Cell Reports, 2023-03-23;42(4):112297.  2023-03-23

IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis
Authors: W Lin, R Niu, SM Park, Y Zou, SS Kim, X Xia, S Xing, Q Yang, X Sun, Z Yuan, S Zhou, D Zhang, HJ Kwon, S Park, C Il Kim, H Koo, Y Liu, H Wu, M Zheng, H Yoo, B Shi, JB Park, J Yin
Nature Communications, 2023-03-22;14(1):1578.  2023-03-22

The 5-lipoxygenase/cyclooxygenase-2 (5-LOX/COX-2) cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis
Authors: F Nakashima, J Giménez-Ba, P Luis, S Presley, R Boer, M Chiusa, T Shibata, G Sulikowski, A Pozzi, C Schneider
The Journal of Biological Chemistry, 2023-02-21;0(0):103050.  2023-02-21

Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
Authors: CH Chang, BJ Lin, CH Chen, NL Nguyen, TH Hsieh, JH Su, MC Chen
Marine Drugs, 2023-01-21;21(2):.  2023-01-21

EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression
Authors: ZS Lin, CC Chung, YC Liu, CH Chang, HC Liu, YY Liang, TL Huang, TM Chen, CH Lee, CH Tang, MC Hung, YH Chen
Elife, 2023-01-09;12(0):.  2023-01-09

Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer
Authors: Lee, K;Lai, T;Lee, W;Chen, Y;Ho, K;Hung, W;Yang, Y;Chan, M;Hsieh, F;Chung, C;Chang, J;Chien, M;
Cancers  2023-01-01

Targeting Ras signaling excitability in cancer cells through combined inhibition of FAK and PI3K
Authors: Chen, C;Wang, S;Yang, J;Huang, C;
bioRxiv  2023-01-01

Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
Authors: SH Park, SJ Yoon, S Choi, J Jung, JY Park, YH Park, J Seo, J Lee, MS Lee, SJ Lee, MY Son, YL Cho, JS Kim, HJ Lee, J Jeong, DS Kim, YJ Park
Experimental & Molecular Medicine, 2022-11-09;0(0):.  2022-11-09

Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates Heparan Sulfate biosynthesis and shapes gastric cancer cell motility and invasion
Authors: C Marques, J Poças, C Gomes, I Faria-Ramo, CA Reis, RR Vivès, A Magalhães
The Journal of Biological Chemistry, 2022-09-28;0(0):102546.  2022-09-28

Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors
Authors: Y Kobayashi, GR Oxnard, EF Cohen, NR Mahadevan, JV Alessi, YP Hung, AA Bertram, DE Heppner, MF Ribeiro, KP Sacardo, R Saddi, MP Macedo, RB Blasco, J Li, KJ Kurppa, T Nguyen, E Voligny, G Ananda, R Chiarle, A Katz, MY Tolstoruko, LM Sholl, PA Jänne
Nature Communications, 2022-09-24;13(1):5614.  2022-09-24

Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells
Authors: M Krchniakov, S Paukovceko, P Chlapek, J Neradil, J Skoda, R Veselska
Frontiers in Pharmacology, 2022-09-07;13(0):976955.  2022-09-07

Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer
Authors: YF Wang, L Yu, ZL Hu, YF Fang, YY Shen, MF Song, Y Chen
Cell Death & Disease, 2022-08-29;13(8):748.  2022-08-29

Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors
Authors: SM Dieter, D Lovecchio, A Pataskar, MK Zowada, PR Körner, A Khalizieva, O van Tellin, D Jäger, H Glimm, R Agami
Oncogene, 2022-07-07;0(0):.  2022-07-07

KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy
Authors: MB Ryan, O Coker, A Sorokin, K Fella, H Barnes, E Wong, P Kanikarla, F Gao, Y Zhang, L Zhou, S Kopetz, RB Corcoran
Cell Reports, 2022-06-21;39(12):110993.  2022-06-21

EGFR inhibition reverses resistance to lenvatinib in hepatocellular carcinoma cells
Authors: X He, Y Hikiba, Y Suzuki, Y Nakamori, Y Kanemaru, M Sugimori, T Sato, A Nozaki, M Chuma, S Maeda
Scientific Reports, 2022-05-14;12(1):8007.  2022-05-14

Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer
Authors: AJ Weickhardt, DK Lau, M Hodgson-Ga, A Lavis, LJ Jenkins, N Vukelic, P Ioannidis, IY Luk, JM Mariadason
BMC Cancer, 2022-05-02;22(1):478.  2022-05-02

EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli
Authors: S Song, Z Yu, Y You, C Liu, X Xie, H Lv, F Xiao, Q Zhu, C Qin
Cell Death & Disease, 2022-04-15;13(4):351.  2022-04-15

Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion
Authors: C Gaiteiro, J Soares, M Relvas-San, A Peixoto, D Ferreira, P Paulo, A Brandão, E Fernandes, R Azevedo, C Palmeira, R Freitas, A Miranda, H Osório, J Prieto, L Lima, AMN Silva, LL Santos, JA Ferreira
Theranostics, 2022-03-28;12(7):3150-3177.  2022-03-28

Different HSP90 Inhibitors Exert Divergent Effect on Myxoid Liposarcoma In Vitro and In Vivo
Authors: C Vannas, L Andersson, S Dolatabadi, P Ranji, M Lindén, E Jonasson, A Ståhlberg, H Fagman, P Åman
Biomedicines, 2022-03-07;10(3):.  2022-03-07

Stem Cells From Human Exfoliated Deciduous Teeth-Conditioned Medium (SHED-CM) is a Promising Treatment for Amyotrophic Lateral Sclerosis
Authors: T Ueda, T Ito, M Inden, H Kurita, A Yamamoto, I Hozumi
Frontiers in Pharmacology, 2022-02-03;13(0):805379.  2022-02-03

Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar
Disease Models & Mechanisms, 2022-01-27;0(0):.  2022-01-27

Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma
Authors: L Scherschin, M Prem, I Kremenetsk, I Tinhofer, P Vajkoczy, AG Karbe, JS Onken
International Journal of Molecular Sciences, 2022-01-17;23(2):.  2022-01-17

Targeting SHP2 sensitizes differentiated thyroid carcinoma to the MEK inhibitor
Authors: J Zhi, J Yi, X Hou, W Wang, W Yang, L Hu, J Huang, S Guo, X Ruan, M Gao, X Zheng
American journal of cancer research, 2022-01-15;12(1):247-264.  2022-01-15

IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma
Authors: H Patel, R Mishra, N Yacoub, S Alanazi, MK Kilroy, JT Garrett
Cancers, 2021-11-22;13(22):.  2021-11-22

Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling Pathways
Authors: TA Mannsåker, T Hoang, SN Aasen, OV Bjørnstad, H Parajuli, T Sundstrøm, FA Thorsen
International Journal of Molecular Sciences, 2021-11-14;22(22):.  2021-11-14

ISL1 promotes enzalutamide resistance in castration-resistant prostate cancer (CRPC) through epithelial to mesenchymal transition (EMT)
Authors: JD Choi, TJ Kim, BC Jeong, HG Jeon, SS Jeon, MY Kang, SY Yeom, SI Seo
Scientific Reports, 2021-11-09;11(1):21984.  2021-11-09

Three newly established immortalized mesothelial cell lines exhibit morphological phenotypes corresponding to malignant mesothelioma epithelioid, intermediate, and sarcomatoid types, respectively
Authors: T Sato, H Nakanishi, K Akao, M Okuda, S Mukai, T Kiyono, Y Sekido
Cancer Cell International, 2021-10-18;21(1):546.  2021-10-18

Characterization of receptor tyrosine kinase activation and biological activity of toceranib phosphate in canine urothelial carcinoma cell lines
Authors: DI Korec, DS Louke, JT Breitbach, JA Geisler, BD Husbands, JM Fenger
Bmc Veterinary Research, 2021-10-02;17(1):320.  2021-10-02

Oral submucous fibrosis stimulates invasion and epithelial-mesenchymal transition in oral squamous cell carcinoma by activating MMP-2 and IGF-IR
Authors: PN Chen, CW Lin, SF Yang, YC Chang
Journal of Cellular and Molecular Medicine, 2021-09-15;0(0):.  2021-09-15

NOTCH1 signaling promotes protein stability of HER3 through the AKT pathway in squamous cell carcinoma of head and neck
Authors: YP Wang, IJ Liu, KC Chen, HC Wu
Oncogenesis, 2021-08-31;10(8):59.  2021-08-31

Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression
Authors: SJ Oh, KH Noh, KH Song, TW Kim
International Journal of Molecular Sciences, 2021-08-17;22(16):.  2021-08-17

Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration
Authors: P Ebner-Peki, L Krisch, M Wolf, S Hochmann, A Hoog, B Vári, K Muigg, R Poupardin, C Scharler, S Schmidhube, E Russe, H Stachelsch, A Schneeberg, K Schallmose, D Strunk
Theranostics, 2021-07-25;11(17):8430-8447.  2021-07-25

Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation
Authors: AC Harttrampf, MEM da Costa, A Renoult, E Daudigeos-, B Geoerger
BMC Cancer, 2021-07-20;21(1):833.  2021-07-20

New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRbeta Signaling
Authors: M Mahdal, J Neradil, P Mudry, S Paukovceko, I Staniczkov, J Urban, P Macsek, L Pazourek, T Tomas, R Veselska
Cancers, 2021-07-15;13(14):.  2021-07-15

Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR-mutant lung cancer with HIF-1alpha/TGF-alpha expression
Authors: K Nishii, K Ohashi, H Watanabe, G Makimoto, T Nakasuka, H Higo, K Ninomiya, Y Kato, T Kubo, K Rai, E Ichihara, K Hotta, M Tabata, Y Maeda, K Kiura
Oncology Letters, 2021-07-07;22(3):639.  2021-07-07

Identification of Phospho-Tyrosine Targets as a Strategy for the Treatment of Esophageal Adenocarcinoma Cells
Authors: J Lee, R Chen, T Mohanakuma, R Bremner, S Mittal, TP Fleming
OncoTargets and Therapy, 2021-06-21;14(0):3813-3820.  2021-06-21

Identification of Nucleolin as a Novel AEG-1-Interacting Protein in Breast Cancer via Interactome Profiling
Authors: SJ Lee, KM Choi, G Bang, SG Park, EB Kim, JW Choi, YH Chung, J Kim, SG Lee, E Kim, JY Kim
Cancers, 2021-06-07;13(11):.  2021-06-07

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
Authors: HH Lee, YN Wang, WH Yang, W Xia, Y Wei, LC Chan, YH Wang, Z Jiang, S Xu, J Yao, Y Qiu, YH Hsu, WL Hwang, M Yan, JH Cha, JL Hsu, J Shen, Y Ye, X Wu, MF Hou, LM Tseng, SC Wang, MR Pan, CH Yang, YL Wang, H Yamaguchi, D Pang, GN Hortobagyi, D Yu, MC Hung
Nature Communications, 2021-05-13;12(1):2788.  2021-05-13

The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells
Authors: S Hafner, M Schmiech, SJ Lang
Frontiers in Pharmacology, 2021-05-05;12(0):611657.  2021-05-05

LRIG1 is a conserved EGFR regulator involved in melanoma development, survival and treatment resistance
Authors: O Billing, Y Holmgren, D Nosek, H Hedman, O Hemmingsso
Oncogene, 2021-05-04;0(0):.  2021-05-04

DNA damage response- and JAK-dependent regulation of PD-L1 expression in head and neck squamous cell carcinoma (HNSCC) cells exposed to 5-fluorouracil (5-FU)
Authors: C Lailler, M Lamuraglia, F Racine, C Louandre, C Godin, B Chauffert, A Galmiche, Z Saidak
Translational Oncology, 2021-05-02;14(8):101110.  2021-05-02

Galectin?9 suppresses the tumor growth of colon cancer in�vitro and in�vivo
Authors: A Morishita, K Nomura, J Tani, K Fujita, H Iwama, K Takuma, M Nakahara, T Tadokoro, K Oura, T Chiyo, S Fujihara, T Niki, M Hirashima, A Nishiyama, T Himoto, T Masaki
Oncology reports, 2021-04-28;45(6):.  2021-04-28

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells
Authors: N Singh, NV Frey, B Engels, DM Barrett, O Shestova, P Ravikumar, KD Cummins, YG Lee, R Pajarillo, I Chun, A Shyu, SL Highfill, A Price, L Zhao, L Peng, B Granda, M Ramones, XM Lu, DA Christian, J Perazzelli, SF Lacey, NH Roy, JK Burkhardt, F Colomb, M Damra, M Abdel-Mohs, T Liu, D Liu, DM Standley, RM Young, JL Brogdon, SA Grupp, CH June, SL Maude, S Gill, M Ruella
Nature Medicine, 2021-04-22;0(0):.  2021-04-22

Identification of a Resistance Mechanism to IGF-IR Targeting in Human Triple Negative MDA-MB-231 Breast Cancer Cells
Authors: J Tsui, S Qi, S Perrino, M Leibovitch, P Brodt
Biomolecules, 2021-04-01;11(4):.  2021-04-01

Effect of cyclic mechanical loading on immunoinflammatory microenvironment in biofabricating hydroxyapatite scaffold for bone regeneration
Authors: P Zhang, X Liu, P Guo, X Li, Z He, Z Li, MJ Stoddart, S Grad, W Tian, D Chen, X Zou, Z Zhou, S Liu
Bioactive materials, 2021-03-09;6(10):3097-3108.  2021-03-09

Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations
Authors: B Royer-Poko, MA Busch, S Tenbusch, M Schmidt, M Beier, AD Woods, H Thiele, J Mora
Cancers, 2020-12-28;13(1):.  2020-12-28

HER3-Receptor-Mediated STAT3 Activation Plays a Central Role in Adaptive Resistance toward Vemurafenib in Melanoma
Authors: L Hüser, MM Kokkalenio, K Granados, J Dworacek, A Federico, M Vierthaler, D Novak, I Arkhypov, T Hielscher, V Umansky, P Altevogt, J Utikal
Cancers, 2020-12-14;12(12):.  2020-12-14

Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines
Authors: M Fuentes-Ba, MP Ventero, JA Encinar, P García-Mor, M Poveda-Del, E Pérez-Vale, VM Barberá, J Gallego-Pl, Á Rodríguez-, J Martín-Nie, M Saceda
Cancers, 2020-12-11;12(12):.  2020-12-11

ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL
Authors: S Pietrobono, G Anichini, C Sala, F Manetti, LL Almada, S Pepe, RM Carr, BD Paradise, JN Sarkaria, JI Davila, L Tofani, I Battisti, G Arrigoni, L Ying, C Zhang, H Li, A Meves, ME Fernandez-, B Stecca
Nat Commun, 2020-11-17;11(1):5865.  2020-11-17

Reduced EGFR and increased miR-221 is associated with increased resistance to temozolomide and radiotherapy in glioblastoma
Authors: Z Areeb, SF Stuart, AJ West, J Gomez, HPT Nguyen, L Paradiso, A Zulkifli, J Jones, AH Kaye, AP Morokoff, RB Luwor
Sci Rep, 2020-10-20;10(1):17768.  2020-10-20

Extracellular SQSTM1 mediates bacterial septic death in mice through insulin receptor signalling
Authors: B Zhou, J Liu, L Zeng, S Zhu, H Wang, TR Billiar, G Kroemer, DJ Klionsky, HJ Zeh, J Jiang, D Tang, R Kang
Nat Microbiol, 2020-10-19;0(0):.  2020-10-19

Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1
Authors: P Hollósi, L Váncza, K Karászi, K Dobos, B Péterfia, E Tátrai, P Tátrai, T Szarvas, S Paku, L Szilák, I Kovalszky
Biomolecules, 2020-09-23;10(10):.  2020-09-23

Sarmentosamide, an Anti-Aging Compound from a Marine-Derived Streptomyces sp. APmarine042
Authors: ES Lee, EY Lee, J Yoon, A Hong, SJ Nam, J Ko
Mar Drugs, 2020-09-10;18(9):.  2020-09-10

LC3B upregulation by NANOG promotes immune resistance and stem-like property through hyperactivation of EGFR signaling in immune-refractory tumor cells
Authors: S Kim, H Cho, SO Hong, SJ Oh, HJ Lee, E Cho, SR Woo, JS Song, JY Chung, SW Son, SM Yoon, YM Jeon, S Jeon, C Yee, KM Lee, SM Hewitt, JH Kim, KH Song, TW Kim
Autophagy, 2020-08-14;0(0):1-20.  2020-08-14

MDM2 Antagonists Induce a Paradoxical Activation of Erk1/2 through a P53-Dependent Mechanism in Dedifferentiated Liposarcomas: Implications for Combinatorial Strategies
Authors: S Roy, A Laroche-Cl, S Verbeke, MA Derieppe, A Italiano
Cancers (Basel), 2020-08-12;12(8):.  2020-08-12

CXCL14 Maintains hESC Self-Renewal through Binding to IGF-1R and Activation of the IGF-1R Pathway
Authors: CL Cheng, SC Yang, CY Lai, CK Wang, CF Chang, CY Lin, WJ Chen, PY Lin, HC Wu, N Ma, FL Lu, J Lu
Cells, 2020-07-16;9(7):.  2020-07-16

Drug resistance mechanisms in Japanese anaplastic lymphoma kinase-positive non-small cell lung cancer and the clinical responses based on the resistant mechanisms
Authors: N Yanagitani, K Uchibori, S Koike, M Tsukahara, S Kitazono, T Yoshizawa, A Horiike, F Ohyanagi, Y Tambo, S Nishikawa, N Fujita, R Katayama, M Nishio
Cancer Sci., 2020-02-08;111(3):932-939.  2020-02-08

Chondroitin sulfate synthase 1 enhances proliferation of glioblastoma by modulating PDGFRA stability
Authors: WC Liao, CK Liao, TJ Tseng, YJ Ho, YR Chen, KH Lin, TJ Lai, CT Lan, KC Wei, CH Liu
Oncogenesis, 2020-02-04;9(2):9.  2020-02-04

C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer
Authors: PC Lee, ST Chen, TC Kuo, TC Lin, MC Lin, J Huang, JS Hung, CL Hsu, HF Juan, PH Lee, MC Huang
Oncogene, 2020-01-31;0(0):.  2020-01-31

Differential Dependency of Human Pancreatic Cancer Cells on Targeting PTEN via PLK 1 Expression
Authors: J Lee, J Lee, W Sim, JH Kim
Cancers (Basel), 2020-01-23;12(2):.  2020-01-23

IGF2 autocrine-mediated IGF1R activation is a clinically relevant mechanism of osimertinib resistance in lung cancer
Authors: T Manabe, H Yasuda, H Terai, H Kagiwada, J Hamamoto, T Ebisudani, K Kobayashi, K Masuzawa, S Ikemura, I Kawada, Y Hayashi, K Fukui, K Horimoto, K Fukunaga, K Soejima
Mol. Cancer Res., 2020-01-15;0(0):.  2020-01-15

Serial Xenotransplantation in NSG Mice Promotes a Hybrid Epithelial/Mesenchymal Gene Expression Signature and Stemness in Rhabdomyosarcoma Cells
Authors: J Skoda, J Neradil, I Staniczkov, A Nunukova, P Macsek, K Borankova, V Dobrotkova, P Nemec, J Sterba, R Veselska
Cancers (Basel), 2020-01-13;12(1):.  2020-01-13

STAT3 Relays a Differential Response to Melanoma-Associated NRAS Mutations
Authors: J Kim, D Novak, C Sachpekidi, J Utikal, L Larribère
Cancers (Basel), 2020-01-02;12(1):.  2020-01-02

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors
Authors: MT Kuo, Y Long, WB Tsai, YY Li, HHW Chen, LG Feun, N Savaraj
Transl Oncol, 2019-12-27;13(2):355-364.  2019-12-27

Mechanisms of entrectinib resistance in a neuroblastoma xenograft model
Authors: SP MacFarland, K Naraparaju, R Iyer, P Guan, V Kolla, Y Hu, K Tan, GM Brodeur
Mol. Cancer Ther., 2019-12-23;0(0):.  2019-12-23

An investigation of the equine epidermal growth factor system during hyperinsulinemic laminitis
Authors: MA de Laat, RJ Spence, MN Sillence, CC Pollitt
PLoS ONE, 2019-12-05;14(12):e0225843.  2019-12-05

EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming
Authors: F Meng, L Wu, L Dong, AV Mitchell, C James Bloc, J Liu, H Zhang, Q Lu, WM Song, B Zhang, W Chen, J Hu, J Wang, Q Yang, M Hüttemann, G Wu
Nat Commun, 2019-11-06;10(1):5033.  2019-11-06

Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas
Authors: Q Zhang, JH Liu, JL Liu, CT Qi, L Yan, Y Chen, Q Yu
BMC Cancer, 2019-11-05;19(1):1044.  2019-11-05

Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra-SRS, with autocrine IGF-1R activation and metastatic potential to the lungs
Authors: S Nakai, S Yamada, H Outani, T Nakai, N Yasuda, H Mae, Y Imura, T Wakamatsu, H Tamiya, T Tanaka, K Hamada, A Tani, A Myoui, N Araki, T Ueda, H Yoshikawa, S Takenaka, N Naka
Sci Rep, 2019-11-01;9(1):15812.  2019-11-01

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
Authors: R Sulahian, JJ Kwon, KH Walsh, E Pailler, TL Bosse, M Thaker, D Almanza, JM Dempster, J Pan, F Piccioni, N Dumont, A Gonzalez, J Rennhack, B Nabet, JA Bachman, A Goodale, Y Lee, M Bagul, R Liao, A Navarro, TL Yuan, RWS Ng, S Raghavan, NS Gray, A Tsherniak, F Vazquez, DE Root, AJ Firestone, J Settleman, WC Hahn, AJ Aguirre
Cell Rep, 2019-10-01;29(1):118-134.e8.  2019-10-01

Epigenomic Profiling Discovers Trans-lineage SOX2 Partnerships Driving Tumor Heterogeneity in Lung Squamous Cell Carcinoma
Authors: T Sato, S Yoo, R Kong, A Sinha, P Chandraman, A Patel, M Fridrikh, O Nagano, T Masuko, MB Beasley, CA Powell, J Zhu, H Watanabe
Cancer Res., 2019-09-24;79(24):6084-6100.  2019-09-24

2-Deoxy-d-Glucose-Induced Metabolic Alteration in Human Oral Squamous SCC15 Cells: Involvement of N-Glycosylation of Axl and Met
Authors: N Lee, WJ Jang, JH Seo, S Lee, CH Jeong
Metabolites, 2019-09-17;9(9):.  2019-09-17

A Role of Agrin in Maintaining the Stability of Vascular Endothelial Growth Factor Receptor-2 during Tumor Angiogenesis
Authors: K Njah, S Chakrabort, B Qiu, S Arumugam, A Raju, AV Pobbati, M Lakshmanan, V Tergaonkar, G Thibault, X Wang, W Hong
Cell Rep, 2019-07-23;28(4):949-965.e7.  2019-07-23

EPHA2 feedback activation limits the response to PDEdelta inhibition in KRAS-dependent cancer cells
Authors: YH Chen, H Lv, N Shen, XM Wang, S Tang, B Xiong, J Ding, MY Geng, M Huang
Acta Pharmacol. Sin., 2019-07-17;41(2):270-277.  2019-07-17

Tumor-specific inhibitory action of decorin on different hepatoma cell lines
Authors: Z Horváth, A Reszegi, L Szilák, T Dankó, I Kovalszky, K Baghy
Cell. Signal., 2019-07-02;62(0):109354.  2019-07-02

Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
Authors: T Matsui, T Chiyo, H Kobara, S Fujihara, K Fujita, D Namima, M Nakahara, N Kobayashi, N Nishiyama, T Yachida, A Morishita, H Iwama, T Masaki
Int J Mol Sci, 2019-06-29;20(13):.  2019-06-29

Intrinsic Resistance to MEK Inhibition Through BET Protein Mediated Kinome Reprogramming in NF1-deficient Ovarian Cancer
Authors: AM Kurimchak, C Shelton, C Herrera-Mo, KE Duncan, J Chernoff, JS Duncan
Mol. Cancer Res., 2019-05-01;0(0):.  2019-05-01

Sonic hedgehog pathway activation is associated with cetuximab resistance and EPHB3 receptor induction in colorectal cancer
Authors: SH Park, MJ Jo, BR Kim, YA Jeong, YJ Na, JL Kim, S Jeong, HK Yun, DY Kim, BG Kim, SH Kang, SC Oh, DH Lee
Theranostics, 2019-04-12;9(8):2235-2251.  2019-04-12

Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach
Authors: Z Xiao, B Sperl, S Gärtner, T Nedelko, E Stacher-Pr, A Ullrich, PG Knyazev
Oncotarget, 2019-04-02;10(26):2546-2560.  2019-04-02

Modeling Patient-Derived Glioblastoma with Cerebral Organoids
Authors: A Linkous, D Balamatsia, M Snuderl, L Edwards, K Miyaguchi, T Milner, B Reich, L Cohen-Goul, A Storaska, Y Nakayama, E Schenkein, R Singhania, S Cirigliano, T Magdeldin, Y Lin, G Nanjangud, K Chadalavad, D Pisapia, C Liston, HA Fine
Cell Rep, 2019-03-19;26(12):3203-3211.e5.  2019-03-19

A multi-targeted probe-based strategy to identify signaling vulnerabilities in cancers
Authors: S Rao, G Du, M Hafner, K Subramania, PK Sorger, NS Gray
J. Biol. Chem., 2019-03-11;0(0):.  2019-03-11

Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis
Authors: L He, L Gao, C Shay, L Lang, F Lv, Y Teng
J. Exp. Clin. Cancer Res., 2019-02-18;38(1):84.  2019-02-18

Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer
Authors: R Graves-Dea, G Bogatcheva, S Rehman, Y Lu, JN Higginboth, B Singh
Oncotarget, 2019-02-12;10(13):1320-1333.  2019-02-12

Epithelial-to-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status
Authors: K Fukuda, S Takeuchi, S Arai, R Katayama, S Nanjo, A Tanimoto, A Nishiyama, T Nakagawa, H Taniguchi, T Suzuki, T Yamada, H Nishihara, H Ninomiya, Y Ishikawa, S Baba, K Takeuchi, A Horiike, N Yanagitani, M Nishio, S Yano
Cancer Res., 2019-02-08;0(0):.  2019-02-08

Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures
Authors: LM van der Wa, J Laoukili, JMJ Jongen, DA Raats, IHM Borel Rink, O Kranenburg
Sci Rep, 2019-01-28;9(1):819.  2019-01-28

SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors
Authors: TA Ahmed, C Adamopoulo, Z Karoulia, X Wu, R Sachidanan, SA Aaronson, PI Poulikakos
Cell Rep, 2019-01-02;26(1):65-78.e5.  2019-01-02

The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors
Authors: X Wang, J Ai, H Liu, X Peng, H Chen, Y Chen, Y Su, A Shen, X Huang, J Ding, M Geng
Mol. Cancer Ther., 2018-12-06;0(0):.  2018-12-06

Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
Authors: SH Choi, AR Kim, JK Nam, JM Kim, JY Kim, HR Seo, HJ Lee, J Cho, YJ Lee
Nat Commun, 2018-11-30;9(1):5108.  2018-11-30

Anticancer activity of paroxetine in human colon cancer cells: Involvement of MET and ERBB3
Authors: WJ Jang, SK Jung, TTL Vo, CH Jeong
J. Cell. Mol. Med., 2018-11-13;0(0):.  2018-11-13

TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling
Authors: STK Sin, Y Li, M Liu, S Ma, XY Guan
Gynecol. Oncol., 2018-11-12;0(0):.  2018-11-12

Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
Authors: J Heliste, A Jokilammi, I Paatero, D Chakrobort, C Stark, T Savunen, M Laaksonen, K Elenius
BMC Cardiovasc Disord, 2018-10-20;18(1):196.  2018-10-20

Targeting of FGF-Signaling Re-Sensitizes Gastrointestinal Stromal Tumors (GIST) to Imatinib In Vitro and In Vivo
Authors: S Boichuk, A Galembikov, P Dunaev, E Micheeva, E Valeeva, M Novikova, N Khromova, P Kopnin
Molecules, 2018-10-15;23(10):.  2018-10-15

Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma
Authors: U Painuly, V Ramakrishn, T Kimlinger, L Wellik, J Haug, W Gonsalves, L Bi, Z Huang, SV Rajkumar, S Kumar
Oncotarget, 2018-10-02;9(77):34582-34594.  2018-10-02

Reviving oncogenic addiction to MET bypassed by BRAF (G469A) mutation
Authors: AR Virzì, A Gentile, S Benvenuti, PM Comoglio
Proc. Natl. Acad. Sci. U.S.A., 2018-09-17;0(0):.  2018-09-17

Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target
Authors: E Yángüez, A Hunziker, MP Dobay, S Yildiz, S Schading, E Elshina, U Karakus, P Gehrig, J Grossmann, R Dijkman, M Schmolke, S Stertz
Nat Commun, 2018-09-11;9(1):3679.  2018-09-11

HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3K/mTOR inhibitor BEZ235 in breast cancer cells via suppressing RTK activation
Authors: S Sun, Y Zhang, J Zheng, B Duan, J Cui, Y Chen, W Deng, B Ye, L Liu, Y Chen, J Du, L Gu
Cell Death Dis, 2018-09-11;9(9):929.  2018-09-11

Effects of Sunitinib and Other Kinase Inhibitors on Cells Harboring a PDGFRB Mutation Associated with Infantile Myofibromatosis
Authors: M Sramek, J Neradil, P Macigova, P Mudry, K Polaskova, O Slaby, H Noskova, J Sterba, R Veselska
Int J Mol Sci, 2018-09-01;19(9):.  2018-09-01

Preclinical Evaluation of Nintedanib, a Triple Angiokinase Inhibitor, in Soft-Tissue Sarcoma: Potential Therapeutic implication for Synovial Sarcoma
Authors: PP Patwardhan, E Musi, GK Schwartz
Mol. Cancer Ther., 2018-08-30;0(0):.  2018-08-30

Silencing of MUC20 suppresses the malignant character of pancreatic ductal adenocarcinoma cells through inhibition of the HGF/MET pathway
Authors: ST Chen, TC Kuo, YY Liao, MC Lin, YW Tien, MC Huang
Oncogene, 2018-07-11;0(0):.  2018-07-11

Melatonin Synergizes with Sorafenib to Suppress Pancreatic Cancer via Melatonin Receptor and PDGFR-?/STAT3 Pathway
Authors: Z Fang, KH Jung, HH Yan, SJ Kim, M Rumman, JH Park, B Han, JE Lee, YW Kang, JH Lim, SS Hong
Cell. Physiol. Biochem., 2018-06-28;47(5):1751-1768.  2018-06-28

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3
Authors: SA Greenall, J Donoghue, TG Johns, TE Adams
Transl Oncol, 2018-06-22;11(4):971-978.  2018-06-22

Identification of FDA-approved oncology drugs with selective potency in high-risk childhood ependymoma
Authors: AM Donson, V Amani, EA Warner, AM Griesinger, DA Witt, JM Mulcahy Le, LM Hoffman, TC Hankinson, MH Handler, R Vibhakar, K Dorris, NK Foreman
Mol. Cancer Ther., 2018-06-20;0(0):.  2018-06-20

YES1 amplification is a mechanism of acquired resistance to EGFR inhibitors identified by transposon mutagenesis and clinical genomics
Authors: PD Fan, G Narzisi, AD Jayaprakas, E Venturini, N Robine, P Smibert, S Germer, HA Yu, EJ Jordan, PK Paik, YY Janjigian, JE Chaft, L Wang, AA Jungbluth, S Middha, L Spraggon, H Qiao, CM Lovly, MG Kris, GJ Riely, K Politi, H Varmus, M Ladanyi
Proc. Natl. Acad. Sci. U.S.A., 2018-06-06;115(26):E6030-E6038.  2018-06-06

A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib
Authors: AH Daneshmane, M Hojjat-Far, A Ghaderi, A Moshfegh, L Hansson, J Schultz, J Vågberg, S Byström, E Olsson, T Olin, A Österborg, H Mellstedt
PLoS ONE, 2018-06-01;13(6):e0198038.  2018-06-01

BET inhibition overcomes receptor tyrosine kinase-mediated cetuximab resistance in HNSCC
Authors: B Leonard, TM Brand, RA O'Keefe, E Lee, Y Zang, JD Kemmer, H Li, JR Grandis, NE Bhola
Cancer Res., 2018-05-23;0(0):.  2018-05-23

Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
Authors: B Haas, V Klinger, C Keksel, V Bonigut, D Kiefer, J Caspers, J Walther, M Wos-Magang, S Weickhardt, G Röhn, M Timmer, R Frötschl, N Eckstein
Cancer Cell Int., 2018-05-04;18(0):69.  2018-05-04

LAMB3 mediates metastatic tumor behavior in papillary thyroid cancer by regulating c-MET/Akt signals
Authors: SN Jung, HS Lim, L Liu, JW Chang, YC Lim, KS Rha, BS Koo
Sci Rep, 2018-02-09;8(1):2718.  2018-02-09

Lrig1 is a haploinsufficient tumor suppressor gene in malignant glioma
Authors: F Mao, C Holmlund, M Faraz, W Wang, T Bergenheim, S Kvarnbrink, M Johansson, R Henriksson, H Hedman
Oncogenesis, 2018-02-02;7(2):13.  2018-02-02

MET or NRAS amplification is an acquired resistance mechanism to the third-generation EGFR inhibitor naquotinib
Authors: K Ninomiya, K Ohashi, G Makimoto, S Tomida, H Higo, H Kayatani, T Ninomiya, T Kubo, E Ichihara, K Hotta, M Tabata, Y Maeda, K Kiura
Sci Rep, 2018-01-31;8(1):1955.  2018-01-31

Distinct dependencies on receptor tyrosine kinases in the regulation of MAPK signaling between BRAF V600E and non-V600E mutant lung cancers
Authors: H Kotani, Y Adachi, H Kitai, S Tomida, H Bando, AC Faber, T Yoshino, DC Voon, S Yano, H Ebi
Oncogene, 2018-01-19;0(0):.  2018-01-19

BRAF inhibition upregulates a variety of receptor tyrosine kinases and their downstream effector Gab2 in colorectal cancer cell lines
Authors: R Herr, S Halbach, M Heizmann, H Busch, M Boerries, T Brummer
Oncogene, 2018-01-12;0(0):.  2018-01-12

Protein C receptor stimulates multiple signaling pathways in breast cancer cells
Authors: D Wang, C Liu, J Wang, Y Jia, X Hu, H Jiang, ZM Shao, YA Zeng
J. Biol. Chem., 2017-12-07;0(0):.  2017-12-07

Differential Effects of EGFL6 on Tumor versus Wound Angiogenesis
Authors: K Noh, LS Mangala, HD Han, N Zhang, S Pradeep, SY Wu, S Ma, E Mora, R Rupaimoole, D Jiang, Y Wen, MMK Shahzad, Y Lyons, M Cho, W Hu, AS Nagaraja, M Haemmerle, CSL Mak, X Chen, KM Gharpure, H Deng, W Xiong, CV Kingsley, J Liu, N Jennings, MJ Birrer, RR Bouchard, G Lopez-Bere, RL Coleman, Z An, AK Sood
Cell Rep, 2017-12-05;21(10):2785-2795.  2017-12-05

High-Throughput Drug Screening Identifies Pazopanib and Clofilium Tosylate as Promising Treatments for Malignant Rhabdoid Tumors
Authors: C Chauvin, A Leruste, A Tauziede-E, M Andrianter, D Surdez, A Lescure, ZY Han, E Anthony, W Richer, S Baulande, M Bohec, S Zaidi, MM Aynaud, L Maillot, J Masliah-Pl, S Cairo, S Roman-Roma, O Delattre, E Del Nery, F Bourdeaut
Cell Rep, 2017-11-14;21(7):1737-1745.  2017-11-14

Overcoming resistance to cetuximab with honokiol, a small-molecule polyphenol
Authors: HE Pearson, M Iida, RA Orbuch, NK McDaniel, KP Nickel, RJ Kimple, J Arbiser, DL Wheeler
Mol. Cancer Ther., 2017-10-20;0(0):.  2017-10-20

EZH2 modifies sunitinib resistance in renal cell carcinoma by kinome reprogramming
Authors: R Adelaiye-O, J Budka, NP Damayanti, J Arrington, MW Ferris, CC Hsu, S Chintala, AR Orillion, KM Miles, L Shen, M Elbanna, E Ciamporcer, S Arisa, P Pettazzoni, GF Draetta, M Seshadri, BA Hancock, M Radovich, J Kota, M Buck, H Keilhack, BP McCarthy, SA Persohn, PR Territo, Y Zang, J Irudayaraj, AW Tao, P Hollenhors, R Pili
Cancer Res., 2017-10-04;0(0):.  2017-10-04

Telmisartan inhibits hepatocellular carcinoma cell proliferation in vitro by inducing cell cycle arrest
Authors: K Oura, T Tadokoro, S Fujihara, A Morishita, T Chiyo, E Samukawa, Y Yamana, K Fujita, T Sakamoto, T Nomura, H Yoneyama, H Kobara, H Mori, H Iwama, K Okano, Y Suzuki, T Masaki
Oncol. Rep., 2017-09-20;38(5):2825-2835.  2017-09-20

Insulin-like Growth Factor-1 signalling is essential for Mitochondrial Biogenesis and Mitophagy in cancer cells
Authors: A Lyons, M Coleman, S Riis, C Favre, CH O'Flanagan, AV Zhdanov, DB Papkovsky, SD Hursting, R O'Connor
J. Biol. Chem., 2017-08-18;0(0):.  2017-08-18

Dual�Targeting�of�Insulin�Receptor�and�KIT�in�Imatinib-Resistant�Gastrointestinal�Stromal�Tumors
Authors: W Chen, Y Kuang, HB Qiu, Z Cao, Y Tu, Q Sheng, G Eilers, Q He, HL Li, M Zhu, Y Wang, R Zhang, Y Wu, F Meng, JA Fletcher, WB Ou
Cancer Res., 2017-07-31;0(0):.  2017-07-31

Mucin 2 silencing promotes colon cancer metastasis through interleukin-6 signaling
Authors: HP Hsu, MD Lai, JC Lee, MC Yen, TY Weng, WC Chen, JH Fang, YL Chen
Sci Rep, 2017-07-19;7(1):5823.  2017-07-19

Altered Met Receptor Phosphorylation and LRP1 Mediated Uptake in Cells Lacking Carbohydrate-Dependent Lysosomal Targeting
Authors: M Aarnio-Pet, P Zhao, SH Yu, C Christian, H Flanagan-S, L Wells, R Steet
J. Biol. Chem., 2017-07-19;0(0):.  2017-07-19

In vitro Cytotoxic Activities of the Oral Platinum(IV) Prodrug Oxoplatin and HSP90 Inhibitor Ganetespib against a Panel of Gastric Cancer Cell Lines
Authors: L Klameth, B Rath, G Hamilton
J Cancer, 2017-07-01;8(10):1733-1743.  2017-07-01

Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells
Authors: R Mansouri, Y Jouan, E Hay, C Blin-Wakka, M Frain, A Ostertag, C Le Henaff, C Marty, V Geoffroy, PJ Marie, M Cohen-Sola, D Modrowski
Cell Death Dis, 2017-06-29;8(6):e2902.  2017-06-29

Podoplanin enhances lung cancer cell growth in vivo by inducing platelet aggregation
Authors: K Miyata, A Takemoto, S Okumura, M Nishio, N Fujita
Sci Rep, 2017-06-22;7(1):4059.  2017-06-22

Mechanisms of primary drug resistance in FGFR1 amplified lung cancer
Authors: F Malchers, MS Ercanoglu, D Schütte, R Castiglion, V Tischler, S Michels, I Dahmen, J Brägelmann, R Menon, JM Heuckmann, J George, S Ansén, ML Sos, A Soltermann, M Peifer, J Wolf, R Büttner, RK Thomas
Clin. Cancer Res., 2017-06-19;0(0):.  2017-06-19

Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
Authors: Benjamin Y Owusu, Shantasia Thomas, Phanindra Venukadas, Zhenfu Han, James W Janetka, Robert A Galemmo, Lidija Klampfer
Oncotarget, 2017-05-29;0(0):1949-2553.  2017-05-29

mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism
Authors: A Lampada, J O'Prey, G Szabadkai, KM Ryan, D Hochhauser, P Salomoni
Cell Death Differ., 2017-05-05;0(0):.  2017-05-05

Piperlongumine downregulates the expression of HER family in breast cancer cells
Authors: HO Jin, JA Park, HA Kim, YH Chang, YJ Hong, IC Park, JK Lee
Biochem. Biophys. Res. Commun., 2017-04-01;0(0):.  2017-04-01

BCL6 promotes glioma and serves as a therapeutic target
Authors: L Xu, Y Chen, M Dutra-Clar, A Mayakonda, M Hazawa, SE Savinoff, N Doan, JW Said, WH Yong, A Watkins, H Yang, LW Ding, YY Jiang, JW Tyner, J Ching, JP Kovalik, V Madan, SL Chan, M Müschen, JJ Breunig, DC Lin, HP Koeffler
Proc. Natl. Acad. Sci. U.S.A, 2017-03-29;0(0):.  2017-03-29

Induction of Neuroendocrine Differentiation in Prostate Cancer Cells by Dovitinib (TKI-258) and its Therapeutic Implications
Authors: SS Yadav, J Li, JA Stockert, B Herzog, J O'Connor, L Garzon-Man, R Parsons, AK Tewari, KK Yadav
Transl Oncol, 2017-03-24;10(3):357-366.  2017-03-24

Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer
Authors: C Li, B Singh, R Graves-Dea, H Ma, A Starchenko, WH Fry, Y Lu, Y Wang, G Bogatcheva, MP Khan, GL Milne, S Zhao, GD Ayers, N Li, H Hu, MK Washington, TJ Yeatman, OG McDonald, Q Liu, RJ Coffey
Proc. Natl. Acad. Sci. U.S.A, 2017-03-20;0(0):.  2017-03-20

Ectodomain Shedding of the Cell Adhesion Molecule Nectin-4 in Ovarian Cancer is Mediated by ADAM10 and ADAM17
Authors: PC Buchanan, KL Boylan, B Walcheck, R Heinze, MA Geller, PA Argenta, AP Skubitz
J. Biol. Chem, 2017-02-23;0(0):.  2017-02-23

Amplification of EGFR wild type alleles in non-small cell lung cancer cells confers acquired resistance to mutation-selective EGFR tyrosine kinase inhibitors
Authors: S Nukaga, H Yasuda, K Tsuchihara, J Hamamoto, K Masuzawa, I Kawada, K Naoki, S Matsumoto, S Mimaki, S Ikemura, K Goto, T Betsuyaku, K Soejima
Cancer Res, 2017-02-15;0(0):.  2017-02-15

Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS
Authors: E Saintas, L Abrahams, GT Ahmad, AM Ajakaiye, AS AlHumaidi, C Ashmore-Ha, I Clark, UK Dura, CN Fixmer, C Ike-Morris, M Mato Prado, D Mccullough, S Mishra, KM Schöler, H Timur, MD Williamson, M Alatsatian, B Bahsoun, E Blackburn, CE Hogwood, PE Lithgow, M Rowe, L Yiangou, F Rothweiler, J Cinatl, R Zehner, AJ Baines, MD Garrett, CW Gourlay, DK Griffin, WJ Gullick, E Hargreaves, MJ Howard, DR Lloyd, JS Rossman, CM Smales, AD Tsaousis, T von der Ha, MN Wass, M Michaelis
PLoS ONE, 2017-02-13;12(2):e0172140.  2017-02-13

MET copy number gain is associated with gefitinib resistance in leptomeningeal carcinomatosis of EGFR-mutant lung cancer
Authors: S Nanjo, S Arai, W Wang, S Takeuchi, T Yamada, A Hata, N Katakami, Y Okada, S Yano
Mol. Cancer Ther, 2017-01-30;0(0):.  2017-01-30

EphA2 is a functional receptor for the growth factor progranulin
Authors: Thomas Neill
J. Cell Biol, 2016-11-30;215(5):687-703.  2016-11-30

Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the Downregulation of Epidermal Growth Factor Receptor
Authors: Maurizio Bifulco
Int. J. Cancer, 2016-11-16;0(0):.  2016-11-16

FRMD6 inhibits human glioblastoma growth and progression by negatively regulating activity of receptor tyrosine kinases
Authors: Y Xu, K Wang, Q Yu
Oncotarget, 2016-10-25;7(43):70080-70091.  2016-10-25

Antitumor efficacy of the heparan sulfate mimic roneparstat (SST0001) against sarcoma models involves multi-target inhibition of receptor tyrosine kinases
Authors: G Cassinelli, E Favini, L Dal Bo, M Tortoreto, M De Maglie, G Dagrada, S Pilotti, F Zunino, N Zaffaroni, C Lanzi
Oncotarget, 2016-07-26;7(30):47848-47863.  2016-07-26

Coronary vasculature patterning requires a novel endothelial ErbB2 holoreceptor
Nat Commun, 2016-06-30;7(0):12038.  2016-06-30

Establishment of a Conditionally Immortalized Wilms Tumor Cell Line with a Homozygous WT1 Deletion within a Heterozygous 11p13 Deletion and UPD Limited to 11p15
PLoS ONE, 2016-05-23;11(5):e0155561.  2016-05-23

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma
Authors: M Huang, T Liu, P Ma, RA Mitteer, Z Zhang, HJ Kim, E Yeo, D Zhang, P Cai, C Li, L Zhang, B Zhao, L Roccogrand, DM O'Rourke, N Dahmane, Y Gong, C Koumenis, Y Fan
J Clin Invest, 2016-04-04;0(0):.  2016-04-04

ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
Authors: Yoshida T, Song L, Bai Y, Kinose F, Li J, Ohaegbulam K, Munoz-Antonia T, Qu X, Eschrich S, Uramoto H, Tanaka F, Nasarre P, Gemmill R, Roche J, Drabkin H, Haura E
PLoS ONE, 2016-01-20;11(1):e0147344.  2016-01-20

ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1
Authors: T Yamaguchi, C Lu, L Ida, K Yanagisawa, J Usukura, J Cheng, N Hotta, Y Shimada, H Isomura, M Suzuki, T Fujimoto, T Takahashi
Nat Commun, 2016-01-04;7(0):10060.  2016-01-04

Activation of EGFR Bypass Signaling by TGF? Overexpression Induces Acquired Resistance to Alectinib in ALK-Translocated Lung Cancer Cells
Authors: T Tani, H Yasuda, J Hamamoto, A Kuroda, D Arai, K Ishioka, K Ohgino, M Miyawaki, I Kawada, K Naoki, Y Hayashi, T Betsuyaku, K Soejima
Mol. Cancer Ther., 2015-12-18;15(1):162-71.  2015-12-18

Impaired dynamin 2 function leads to increased AP-1 transcriptional activity through the JNK/c-Jun pathway.
Authors: Szymanska E, Skowronek A, Miaczynska M
Cell Signal, 2015-10-22;28(1):160-71.  2015-10-22

Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
Authors: Chung S, Dwabe S, Elshimali Y, Sukhija H, Aroh C, Vadgama J
PLoS ONE, 2015-08-10;10(8):e0134948.  2015-08-10

Biologically active LIL proteins built with minimal chemical diversity.
Authors: Heim E, Marston J, Federman R, Edwards A, Karabadzhak A, Petti L, Engelman D, DiMaio D
Proc Natl Acad Sci U S A, 2015-08-10;112(34):E4717-25.  2015-08-10

Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors.
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Cancer Res, 2015-04-02;75(10):2061-70.  2015-04-02

Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status.
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BMC Cancer, 2015-03-26;15(0):184.  2015-03-26

MITF Modulates Therapeutic Resistance through EGFR Signaling.
Authors: Ji Z, Erin Chen Y, Kumar R, Taylor M, Jenny Njauw C, Miao B, Frederick D, Wargo J, Flaherty K, Jonsson G, Tsao H
J Invest Dermatol, 2015-03-19;135(7):1863-72.  2015-03-19

Artificial human Met agonists based on macrocycle scaffolds.
Authors: Ito, Kenichir, Sakai, Katsuya, Suzuki, Yoshinor, Ozawa, Naoya, Hatta, Tomohisa, Natsume, Tohru, Matsumoto, Kunio, Suga, Hiroaki
Nat Commun, 2015-03-11;6(0):6373.  2015-03-11

Extracellular superoxide dismutase regulates the expression of small gtpase regulatory proteins GEFs, GAPs, and GDI.
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PLoS ONE, 2015-03-09;10(3):e0121441.  2015-03-09

Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer.
Authors: Song A, Kim T, Kim D, Kim S, Keam B, Lee S, Heo D
Clin Cancer Res, 2015-02-16;21(10):2379-87.  2015-02-16

Preclinical trials for prevention of tumor progression of hepatocellular carcinoma by LZ-8 targeting c-Met dependent and independent pathways.
Authors: Wu, Jia-Ru, Hu, Chi-Tan, You, Ren-In, Ma, Pei-Ling, Pan, Siou-Mei, Lee, Ming-Che, Wu, Wen-Shen
PLoS ONE, 2015-01-21;10(1):e0114495.  2015-01-21

LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation.
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J Virol, 2014-12-17;89(5):2590-602.  2014-12-17

Regulation of prostate stromal fibroblasts by the PIM1 protein kinase.
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Cell Signal, 2014-10-28;27(1):135-46.  2014-10-28

A phase I study of continuous oral dosing of OSI-906, a dual inhibitor of insulin-like growth factor-1 and insulin receptors, in patients with advanced solid tumors.
Authors: Puzanov I, Lindsay C, Goff L, Sosman J, Gilbert J, Berlin J, Poondru S, Simantov R, Gedrich R, Stephens A, Chan E, Evans T
Clin Cancer Res, 2014-09-11;21(4):701-11.  2014-09-11

Combined targeting of mTOR and c-MET signaling pathways for effective management of epithelioid sarcoma.
Authors: Imura, Yoshinor, Yasui, Hirohiko, Outani, Hidetats, Wakamatsu, Toru, Hamada, Kenichir, Nakai, Takaaki, Yamada, Shutaro, Myoui, Akira, Araki, Nobuhito, Ueda, Takafumi, Itoh, Kazuyuki, Yoshikawa, Hideki, Naka, Norifumi
Mol Cancer, 2014-08-07;13(0):185.  2014-08-07

Transgenic expression of the N525S-tuberin variant in Tsc2 mutant (Eker) rats causes dominant embryonic lethality.
Authors: Shiono, Masatosh, Kobayashi, Toshiyuk, Takahashi, Riichi, Ueda, Masatsug, Ishioka, Chikashi, Hino, Okio
Sci Rep, 2014-08-04;4(0):5927.  2014-08-04

Establishment of a novel clear cell sarcoma cell line (Hewga-CCS), and investigation of the antitumor effects of pazopanib on Hewga-CCS.
Authors: Outani, Hidetats, Tanaka, Takaaki, Wakamatsu, Toru, Imura, Yoshinor, Hamada, Kenichir, Araki, Nobuhito, Itoh, Kazuyuki, Yoshikawa, Hideki, Naka, Norifumi
BMC Cancer, 2014-06-19;14(0):455.  2014-06-19

Ligand-associated ERBB2/3 activation confers acquired resistance to FGFR inhibition in FGFR3-dependent cancer cells.
Authors: Wang, J, Mikse, O, Liao, R G, Li, Y, Tan, L, Janne, P A, Gray, N S, Wong, K-K, Hammerman, P S
Oncogene, 2014-06-09;34(17):2167-77.  2014-06-09

MicroRNA-133a suppresses multiple oncogenic membrane receptors and cell invasion in non-small cell lung carcinoma.
Authors: Wang, Lu-Kai, Hsiao, Tzu-Hung, Hong, Tse-Ming, Chen, Hsuan-Yu, Kao, Shih-Han, Wang, Wen-Lung, Yu, Sung-Lia, Lin, Ching-We, Yang, Pan-Chyr
PLoS ONE, 2014-05-09;9(5):e96765.  2014-05-09

Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling.
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BMC Cancer, 2014-04-30;14(0):302.  2014-04-30

Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis.
Authors: Calero R, Morchon E, Johnsen J, Serrano R
PLoS ONE, 2014-04-23;9(4):e95628.  2014-04-23

Expressed glycosylphosphatidylinositol-anchored horseradish peroxidase identifies co-clustering molecules in individual lipid raft domains.
Authors: Miyagawa-Yamaguchi, Arisa, Kotani, Norihiro, Honke, Koichi
PLoS ONE, 2014-03-26;9(3):e93054.  2014-03-26

JNK signaling mediates EPHA2-dependent tumor cell proliferation, motility, and cancer stem cell-like properties in non-small cell lung cancer.
Authors: Song W, Ma Y, Wang J, Brantley-Sieders D, Chen J
Cancer Res, 2014-03-07;74(9):2444-54.  2014-03-07

Improvement of human keratinocyte migration by a redox active bioelectric dressing.
Authors: Banerjee J, Das Ghatak P, Roy S, Khanna S, Sequin E, Bellman K, Dickinson B, Suri P, Subramaniam V, Chang C, Sen C
PLoS ONE, 2014-03-03;9(3):e89239.  2014-03-03

Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells.
Authors: Sakanyan V, Angelini M, Le Bechec M, Lecocq M, Benaiteau F, Rousseau B, Gyulkhandanyan A, Gyulkhandanyan L, Loge C, Reiter E, Roussakis C, Fleury F
Sci Rep, 2014-02-05;4(0):3977.  2014-02-05

Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma.
Authors: Carlino M, Todd J, Gowrishankar K, Mijatov B, Pupo G, Fung C, Snoyman S, Hersey P, Long G, Kefford R, Rizos H
Mol Oncol, 2014-01-15;8(3):544-54.  2014-01-15

Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRbeta aptamer.
Authors: Camorani S, Esposito C, Rienzo A, Catuogno S, Iaboni M, Condorelli G, de Franciscis V, Cerchia L
Mol Ther, 2014-01-02;22(4):828-41.  2014-01-02

Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer.
Authors: Davies, Kurtis D, Mahale, Sakshi, Astling, David P, Aisner, Dara L, Le, Anh T, Hinz, Trista K, Vaishnavi, Aria, Bunn, Paul A J, Heasley, Lynn E, Tan, Aik-Choo, Camidge, D Ross, Varella-Garcia, Marileil, Doebele, Robert C
PLoS ONE, 2013-12-13;8(12):e82236.  2013-12-13

The uremic toxin adsorbent AST-120 abrogates cardiorenal injury following myocardial infarction.
Authors: Lekawanvijit S, Kumfu S, Wang B, Manabe M, Nishijima F, Kelly D, Krum H, Kompa A
PLoS ONE, 2013-12-13;8(12):e83687.  2013-12-13

Liver kinase B1 expression promotes phosphatase activity and abrogation of receptor tyrosine kinase phosphorylation in human cancer cells.
Authors: Okon I, Coughlan K, Zou M
J Biol Chem, 2013-11-27;289(3):1639-48.  2013-11-27

Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin.
Authors: de-Freitas-Junior J, Carvalho S, Dias A, Oliveira P, Cabral J, Seruca R, Oliveira C, Morgado-Diaz J, Reis C, Pinho S
PLoS ONE, 2013-11-25;8(11):e81579.  2013-11-25

EGFR signaling in the HGG-02 glioblastoma cell line with an unusual loss of EGFR gene copy.
Authors: Skoda J, Neradil J, Zitterbart K, Sterba J, Veselska R
Oncol Rep, 2013-11-20;31(1):480-7.  2013-11-20

Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets.
Authors: Drake J, Graham N, Lee J, Stoyanova T, Faltermeier C, Sud S, Titz B, Huang J, Pienta K, Graeber T, Witte O
Proc Natl Acad Sci U S A, 2013-11-18;110(49):E4762-9.  2013-11-18

Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency.
Authors: Son M, Seol B, Han Y, Cho Y
Hum Mol Genet, 2013-11-11;23(7):1802-16.  2013-11-11

A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor alpha.
Authors: Lei H, Kazlauskas A
Mol Cell Biol, 2013-11-04;34(1):110-22.  2013-11-04

Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up.
Authors: Ugurel S, Mentzel T, Utikal J, Helmbold P, Mohr P, Pfohler C, Schiller M, Hauschild A, Hein R, Kampgen E, Kellner I, Leverkus M, Becker J, Strobel P, Schadendorf D
Clin Cancer Res, 2013-10-30;20(2):499-510.  2013-10-30

An EGFR wild type-EGFRvIII-HB-EGF feed-forward loop regulates the activation of EGFRvIII.
Authors: Li L, Chakraborty S, Yang C, Hatanpaa K, Cipher D, Puliyappadamba V, Rehman A, Jiwani A, Mickey B, Madden C, Raisanen J, Burma S, Saha D, Wang Z, Pingle S, Kesari S, Boothman D, Habib A
Oncogene, 2013-09-30;33(33):4253-64.  2013-09-30

Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.
Authors: Kwon, Heung Su, Johnson, Thomas V, Joe, Myung Ku, Abu-Asab, Mones, Zhang, Jun, Chan, Chi Chao, Tomarev, Stanisla
J Biol Chem, 2013-07-29;288(37):26357-71.  2013-07-29

MEK inhibition affects STAT3 signaling and invasion in human melanoma cell lines.
Authors: Vultur A, Villanueva J, Krepler C, Rajan G, Chen Q, Xiao M, Li L, Gimotty P, Wilson M, Hayden J, Keeney F, Nathanson K, Herlyn M
Oncogene, 2013-04-29;33(14):1850-61.  2013-04-29

Host cell entry of respiratory syncytial virus involves macropinocytosis followed by proteolytic activation of the F protein.
Authors: Krzyzaniak M, Zumstein M, Gerez J, Picotti P, Helenius A
PLoS Pathog, 2013-04-11;9(4):e1003309.  2013-04-11

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.
Authors: Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy C, Wetzel K, George E, Popa M, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither L, Bentires-Alj M
Proc Natl Acad Sci U S A, 2013-02-19;110(11):E1026-34.  2013-02-19

Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migration.
Authors: Lee H, Bennett A
Mol Cell Biol, 2013-01-28;33(7):1430-41.  2013-01-28

Active kinase profiling, genetic and pharmacological data define mTOR as an important common target in triple-negative breast cancer.
Authors: Montero J, Esparis-Ogando A, Re-Louhau M, Seoane S, Abad M, Calero R, Ocana A, Pandiella A
Oncogene, 2012-12-17;33(2):148-56.  2012-12-17

Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27.
Authors: Lin, Shih-Pei, Lee, Yi-Ting, Wang, Jir-You, Miller, Stephani, Chiou, Shih-Hwa, Hung, Mien-Chi, Hung, Shih-Chi
PLoS ONE, 2012-11-20;7(11):e49605.  2012-11-20

Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma.
Authors: Purushothaman, Anurag, Babitz, Stephen, Sanderson, Ralph D
J Biol Chem, 2012-10-09;287(49):41288-96.  2012-10-09

Evaluation of tyrosine kinase inhibitor combinations for glioblastoma therapy.
Authors: Joshi, Avadhut, Loilome, Watchari, Siu, I-Mei, Tyler, Betty, Gallia, Gary L, Riggins, Gregory
PLoS ONE, 2012-10-02;7(10):e44372.  2012-10-02

Fibroblast Growth Factor Receptor 3 (FGFR3) Associated with the CD20 Antigen Regulates the Rituximab-induced Proliferation Inhibition in B-cell Lymphoma Cells.
Authors: Kotani N, Ishiura Y, Yamashita R, Ohnishi T, Honke K
J Biol Chem, 2012-08-29;287(44):37109-18.  2012-08-29

Identifying and targeting ROS1 gene fusions in non-small cell lung cancer.
Clin. Cancer Res., 2012-08-23;18(17):4570-9.  2012-08-23

Prostaglandin E(2) induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway.
J. Immunol., 2012-07-27;189(5):2563-73.  2012-07-27

PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma.
Authors: Ho A, Vasudeva S, Lae M, Saito T, Barbashina V, Antonescu C, Ladanyi M, Schwartz G
Cancer Res, 2012-07-10;72(17):4515-25.  2012-07-10

Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.
Authors: Duncan J, Whittle M, Nakamura K, Abell A, Midland A, Zawistowski J, Johnson N, Granger D, Jordan N, Darr D, Usary J, Kuan P, Smalley D, Major B, He X, Hoadley K, Zhou B, Sharpless N, Perou C, Kim W, Gomez S, Chen X, Jin J, Frye S, Earp H, Graves L, Johnson G
Cell, 2012-04-13;149(2):307-21.  2012-04-13

Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.
Authors: Oliveras-Ferraros C, Cufi S, Queralt B, Vazquez-Martin A, Martin-Castillo B, de Llorens R, Bosch-Barrera J, Brunet J, Menendez JA
Br. J. Cancer, 2012-04-10;106(8):1406-14.  2012-04-10

Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors.
Authors: Bai Y, Li J, Fang B, Edwards A, Zhang G, Bui M, Eschrich S, Altiok S, Koomen J, Haura E
Cancer Res, 2012-03-29;72(10):2501-11.  2012-03-29

Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition.
Authors: Gowrishankar K, Snoyman S, Pupo GM, Becker TM, Kefford RF, Rizos H
J. Invest. Dermatol., 2012-03-22;132(7):1850-9.  2012-03-22

Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency.
Authors: Ball SG, Shuttleworth A, Kielty CM
Stem Cells, 2012-03-01;30(3):548-60.  2012-03-01

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).
Authors: Poulikakos PI, Persaud Y, Janakiraman M
Nature, 2011-11-23;480(7377):387-90.  2011-11-23

MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway.
Authors: Lorenzon E, Colladel R, Andreuzzi E, Marastoni S, Todaro F, Schiappacassi M, Ligresti G, Colombatti A, Mongiat M
Oncogene, 2011-10-24;31(26):3136-47.  2011-10-24

Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane.
Authors: Tang WH, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, Tacconelli S, Capone M, Evangelista V, Levantesi G, Wen L, Martin K, Minuz P, Rade J, Patrignani P, Hwa J
J. Clin. Invest., 2011-10-17;121(11):4462-76.  2011-10-17

Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation.
Authors: Jiao Y, Ou W, Meng F
Mol. Cancer, 2011-09-30;10(0):125.  2011-09-30

Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification.
Authors: Tanizaki J, Okamoto I, Sakai K
Br. J. Cancer, 2011-08-16;105(6):807-13.  2011-08-16

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
Authors: Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoel M, Raffelsberger W, Poch O, McKeating JA, Brino L, Baumert TF
Nat. Med., 2011-04-24;17(5):589-95.  2011-04-24

Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2.
Authors: Tanabe H, Kuribayashi K, Tsuji N
Int. J. Oncol., 2011-04-18;39(1):33-40.  2011-04-18

The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation.
Authors: Karki R, Lang SM, Means RE
PLoS Pathog., 2011-04-07;7(4):e1001331.  2011-04-07

Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.
Authors: Carrasco-Garcia E, Saceda M, Grasso S, Rocamora-Reverte L, Conde M, Gomez-Martinez A, Garcia-Morales P, Ferragut JA, Martinez-Lacaci I
Exp. Cell Res., 2011-04-01;317(10):1476-89.  2011-04-01

Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells.
Authors: Ding VM, Boersema PJ, Foong LY
PLoS ONE, 2011-03-17;6(3):e17538.  2011-03-17

Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion.
Authors: Henriksson ML, Edin S, Dahlin AM, Oldenborg PA, Oberg Ã…, Van Guelpen B, Rutegard J, Stenling R, Palmqvist R
Am. J. Pathol., 2011-03-01;178(3):1387-94.  2011-03-01

Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors.
Authors: Chakrabarty A, Sanchez V, Kuba MG, Rinehart C, Arteaga CL
Proc. Natl. Acad. Sci. U.S.A., 2011-02-28;109(8):2718-23.  2011-02-28

18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer.
Authors: McKinley ET, Bugaj JE, Zhao P, Guleryuz S, Mantis C, Gokhale PC, Wild R, Manning HC
Clin. Cancer Res., 2011-01-21;17(10):3332-40.  2011-01-21

Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.
Authors: Ou WB, Hubert C, Corson JM, Bueno R, Flynn DL, Sugarbaker DJ, Fletcher JA
Neoplasia, 2011-01-01;13(1):12-22.  2011-01-01

Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
Authors: Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis M, Cipolla AK, Wubbenhorst B, Xu X, Gimotty PA, Kee D, Santiago-Walker AE, Letrero R, D'Andrea K, Pushparajan A, Hayden JE, Brown KD, Laquerre S, McArthur GA, Sosman JA, Nathanson KL, Herlyn M
Cancer Cell, 2010-12-14;18(6):683-95.  2010-12-14

A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma.
Authors: Godshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban R, Kidd KK, Weidhaas JB, Slack FJ
Oncogene, 2010-11-29;30(13):1542-50.  2010-11-29

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
Authors: Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, Chodon T, Nelson SF, McArthur G, Sosman JA, Ribas A, Lo RS
Nature, 2010-11-24;468(7326):973-7.  2010-11-24

Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation.
Authors: Csepeggi C, Jiang M, Kojima F
J. Biol. Chem., 2010-11-17;286(3):2078-87.  2010-11-17

Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer.
Authors: Suda K, Murakami I, Katayama T, Tomizawa K, Osada H, Sekido Y, Maehara Y, Yatabe Y, Mitsudomi T
Clin. Cancer Res., 2010-11-09;16(22):5489-98.  2010-11-09

The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.
Authors: Flanigan SA, Pitts TM, Eckhardt SG, Tentler JJ, Tan AC, Thorburn A, Leong S
Clin. Cancer Res., 2010-10-13;16(22):5436-46.  2010-10-13

Pathway-focused proteomic signatures in HER2-overexpressing breast cancer with a basal-like phenotype: new insights into de novo resistance to trastuzumab (Herceptin).
Authors: Oliveras-Ferraros C, Vazquez-Martin A, Martin-Castillo B, Perez-Martinez MC, Cufi S, Del Barco S, Bernado L, Brunet J, Lopez-Bonet E, Menendez JA
Int. J. Oncol., 2010-09-01;37(3):669-78.  2010-09-01

Coactivated platelet-derived growth factor receptor alpha and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.
Authors: Dewaele B, Floris G, Finalet-Ferreiro J, Fletcher CD, Coindre JM, Guillou L, Hogendoorn PC, Wozniak A, Vanspauwen V, Schoffski P, Marynen P, Vandenberghe P, Sciot R, Debiec-Rychter M
Cancer Res., 2010-08-04;70(18):7304-14.  2010-08-04

Somatic cell plasticity and Niemann-pick type C2 protein: adipocyte differentiation and function.
Authors: Csepeggi C, Jiang M, Frolov A
J. Biol. Chem., 2010-07-22;285(39):30347-54.  2010-07-22

Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch.
Authors: Ding W, Knox TR, Tschumper RC
Blood, 2010-07-06;116(16):2984-93.  2010-07-06

Sunitinib in metastatic thymic carcinomas: laboratory findings and initial clinical experience.
Authors: Strobel P, Bargou R, Wolff A, Spitzer D, Manegold C, Dimitrakopoulou-Strauss A, Strauss L, Sauer C, Mayer F, Hohenberger P, Marx A
Br. J. Cancer, 2010-06-22;103(2):196-200.  2010-06-22

Functional mapping of receptor tyrosine kinases in myxoid liposarcoma.
Authors: Negri T, Virdis E, Brich S, Bozzi F, Tamborini E, Tarantino E, Jocolle G, Cassinelli G, Grosso F, Sanfilippo R, Casalini P, Greco A, Pierotti MA, Pilotti S
Clin. Cancer Res., 2010-06-03;16(14):3581-93.  2010-06-03

Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response.
Authors: Stacchiotti S, Negri T, Palassini E, Conca E, Gronchi A, Morosi C, Messina A, Pastorino U, Pierotti MA, Casali PG, Pilotti S
Mol. Cancer Ther., 2010-05-01;9(5):1286-97.  2010-05-01

Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells.
Authors: Kang HG, Jenabi JM, Liu XF, Reynolds CP, Triche TJ, Sorensen PH
Mol. Cancer Ther., 2010-04-27;9(5):1396-407.  2010-04-27

VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
Eur. J. Cancer, 2010-01-22;46(5):974-82.  2010-01-22

Human cancers converge at the HIF-2alpha oncogenic axis.
Authors: Franovic A, Holterman CE, Payette J, Lee S
Proc. Natl. Acad. Sci. U.S.A., 2009-12-02;106(50):21306-11.  2009-12-02

Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction.
Authors: Cook SA, Varela-Carver A, Mongillo M
Eur. Heart J., 2009-10-01;31(1):100-11.  2009-10-01

Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells.
Authors: Yoon YK, Kim HP, Han SW, Hur HS, Oh do Y, Im SA, Bang YJ, Kim TY
Mol. Cancer Ther., 2009-09-15;8(9):2526-36.  2009-09-15

EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines.
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Clin. Cancer Res., 2009-09-08;15(18):5753-61.  2009-09-08

A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells.
Authors: Eiselleova L, Matulka K, Kriz V, Kunova M, Schmidtova Z, Neradil J, Tichy B, Dvorakova D, Pospisilova S, Hampl A, Dvorak P
Stem Cells, 2009-08-01;27(8):1847-57.  2009-08-01

Decorin is a novel antagonistic ligand of the Met receptor.
Authors: Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
J. Cell Biol., 2009-05-11;185(4):743-54.  2009-05-11

Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.
Authors: Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, Kondo Y, Osada H, Usami N, Yokoi K, Ueda Y, Yatabe Y, Ito M, Horio Y, Hida T, Sekido Y
Carcinogenesis, 2009-04-20;30(7):1097-105.  2009-04-20

Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells.
Authors: Eckstein N, Servan K, Hildebrandt B, Politz A, von Jonquieres G, Wolf-Kummeth S, Napierski I, Hamacher A, Kassack MU, Budczies J, Beier M, Dietel M, Royer-Pokora B, Denkert C, Royer HD
Cancer Res., 2009-03-24;69(7):2996-3003.  2009-03-24

Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells.
Authors: Kobayashi T, Furukawa Y, Kikuchi J, Ito C, Miyata Y, Muto S, Tanaka A, Kusano E
Kidney Int., 2009-02-25;75(11):1173-83.  2009-02-25

Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells.
Authors: Agarwal S, Zerillo C, Kolmakova J, Christensen JG, Harris LN, Rimm DL, Digiovanna MP, Stern DF
Br. J. Cancer, 2009-02-24;100(6):941-9.  2009-02-24

A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells.
Authors: Kashiwagi K, Virgona N, Harada K, Kido W, Yano Y, Ando A, Hagiwara K, Yano T
Life Sci., 2009-02-14;84(19):650-6.  2009-02-14

Response to sunitinib malate in advanced alveolar soft part sarcoma.
Authors: Stacchiotti S, Tamborini E, Marrari A, Brich S, Rota SA, Orsenigo M, Crippa F, Morosi C, Gronchi A, Pierotti MA, Casali PG, Pilotti S
Clin. Cancer Res., 2009-02-01;15(3):1096-104.  2009-02-01

Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response.
Authors: Marston E, Weston V, Jesson J, Maina E, McConville C, Agathanggelou A, Skowronska A, Mapp K, Sameith K, Powell JE, Lawson S, Kearns P, Falciani F, Taylor M, Stankovic T
Blood, 2008-10-21;113(1):117-26.  2008-10-21

Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors.
Authors: Buck E, Eyzaguirre A, Rosenfeld-Franklin M, Thomson S, Mulvihill M, Barr S, Brown E, O'Connor M, Yao Y, Pachter J, Miglarese M, Epstein D, Iwata KK, Haley JD, Gibson NW, Ji QS
Cancer Res., 2008-10-15;68(20):8322-32.  2008-10-15

Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
Authors: Shimamura T, Li D, Ji H, Haringsma HJ, Liniker E, Borgman CL, Lowell AM, Minami Y, McNamara K, Perera SA, Zaghlul S, Thomas RK, Greulich H, Kobayashi S, Chirieac LR, Padera RF, Kubo S, Takahashi M, Tenen DG, Meyerson M, Wong KK, Shapiro GI
Cancer Res., 2008-07-15;68(14):5827-38.  2008-07-15

EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.
Authors: Koivunen JP, Mermel C, Zejnullahu K, Murphy C, Lifshits E, Holmes AJ, Choi HG, Kim J, Chiang D, Thomas R, Lee J, Richards WG, Sugarbaker DJ, Ducko C, Lindeman N, Marcoux JP, Engelman JA, Gray NS, Lee C, Meyerson M, Janne PA
Clin. Cancer Res., 2008-07-01;14(13):4275-83.  2008-07-01

Molecular characterization of pediatric gastrointestinal stromal tumors.
Authors: Agaram NP, Laquaglia MP, Ustun B, Guo T, Wong GC, Socci ND, Maki RG, DeMatteo RP, Besmer P, Antonescu CR
Clin. Cancer Res., 2008-05-15;14(10):3204-15.  2008-05-15

Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells.
Authors: Mueller KL, Hunter LA, Ethier SP, Boerner JL
Cancer Res., 2008-05-01;68(9):3314-22.  2008-05-01

Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
Authors: Yu L, Saile K, Swartz CD, He H, Zheng X, Kissling GE, Di X, Lucas S, Robboy SJ, Dixon D
Mol. Med., 2008-05-01;14(5):264-75.  2008-05-01

FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.
Authors: Kunii K, Davis L, Gorenstein J, Hatch H, Yashiro M, Di Bacco A, Elbi C, Lutterbach B
Cancer Res., 2008-04-01;68(7):2340-8.  2008-04-01

Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells.
Authors: Eckstein N, Servan K, Girard L, Cai D, von Jonquieres G, Jaehde U, Kassack MU, Gazdar AF, Minna JD, Royer HD
J. Biol. Chem., 2007-10-17;283(2):739-50.  2007-10-17

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.
Authors: Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA
Science, 2007-09-13;318(5848):287-90.  2007-09-13

Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling.
Authors: Wang L, Schulz TC, Sherrer ES, Dauphin DS, Shin S, Nelson AM, Ware CB, Zhan M, Song CZ, Chen X, Brimble SN, McLean A, Galeano MJ, Uhl EW, D'Amour KA, Chesnut JD, Rao MS, Blau CA, Robins AJ
Blood, 2007-08-29;110(12):4111-9.  2007-08-29

Fibulin-5 binds human smooth-muscle cells through alpha5beta1 and alpha4beta1 integrins, but does not support receptor activation.
Authors: Lomas AC, Mellody KT, Freeman LJ, Bax DV, Shuttleworth CA, Kielty CM
Biochem. J., 2007-08-01;405(3):417-28.  2007-08-01

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Authors: Ball SG, Shuttleworth CA, Kielty CM
J. Cell Biol., 2007-04-30;177(3):489-500.  2007-04-30

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.
Authors: Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Janne PA
Science, 2007-04-26;316(5827):1039-43.  2007-04-26

E-cadherin cell-cell adhesion in ewing tumor cells mediates suppression of anoikis through activation of the ErbB4 tyrosine kinase.
Authors: Kang HG, Jenabi JM, Zhang J, Keshelava N, Shimada H, May WA, Ng T, Reynolds CP, Triche TJ, Sorensen PH
Cancer Res., 2007-04-01;67(7):3094-105.  2007-04-01

Des-gamma-carboxyl prothrombin-promoted vascular endothelial cell proliferation and migration.
Authors: Fujikawa T, Shiraha H, Ueda N, Takaoka N, Nakanishi Y, Matsuo N, Tanaka S, Nishina S, Suzuki M, Takaki A, Sakaguchi K, Shiratori Y
J. Biol. Chem., 2007-01-25;282(12):8741-8.  2007-01-25

Trastuzumab in combination with heregulin-activated Her-2 (erbB-2) triggers a receptor-enhanced chemosensitivity effect in the absence of Her-2 overexpression.
Authors: Menendez JA, Mehmi I, Lupu R
J. Clin. Oncol., 2006-07-17;24(23):3735-46.  2006-07-17

Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.
Authors: Cohen EE, Lingen MW, Zhu B, Zhu H, Straza MW, Pierce C, Martin LE, Rosner MR
Cancer Res., 2006-06-15;66(12):6296-303.  2006-06-15