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Rat IL-6 Antibody

Catalog #: AF506
50 Citations Datasheet / COA / SDS
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AF506
AF506-SP
Detection of Rat IL‑6 by Western Blot.
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Citations (50)
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Rat IL-6 Antibody Summary

Species Reactivity
Rat
Specificity
Detects rat and mouse IL-6 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant cotton rat IL‑6 is observed, and less than 1% cross-reactivity with recombinant human IL-6 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant rat IL-6
Phe25-Thr211
Accession # P20607
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Immunocytochemistry
5-15 µg/mL
See below
Neutralization
Measured by its ability to neutralize IL‑6-induced proliferation in the T1165.85.2.1 mouse plasmacytoma cell line. Nordan, R.P. and M. Potter (1986) Science 233:566. The Neutralization Dose (ND50) is typically <0.5 µg/mL in the presence of 0.6 ng/mL Recombinant Rat IL‑6.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Rat IL-6 antibody by Western Blot. View Larger

Detection of Rat IL‑6 by Western Blot. Western blot shows lysates of NR8383 rat alveolar macrophage cell line untreated (-) or treated (+) with LPS. PVDF membrane was probed with 1 µg/mL of Goat Anti-Rat IL-6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF506) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for IL-6 at approximately 22 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry View Larger

IL‑6 in NR8383 Rat Cell Line. IL‑6 was detected in immersion fixed NR8383 rat alveolar macrophage cell line using Goat Anti-Rat IL‑6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF506) at 5 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to cyoplasm. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Neutralization Cell Proliferation Induced by IL‑6 and Neutralization by Rat IL‑6 Antibody. View Larger

Cell Proliferation Induced by IL‑6 and Neutralization by Rat IL‑6 Antibody. Recombinant Rat IL-6 (Catalog # 506-RL) stimulates proliferation in the T1165.85.2.1 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Rat IL-6 (0.6 ng/mL) is neutralized (green line) by increasing concentrations of Rat IL-6 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF506). The ND50 is typically <0.5 µg/mL.

Immunohistochemistry-Frozen Detection of Porcine IL-6 by Immunohistochemistry-Frozen View Larger

Detection of Porcine IL-6 by Immunohistochemistry-Frozen Diverse localization of measured cytokines in P7 brains. Representative pictures (100× magnification) of immunohistochemical stainings of IL-1 beta (Α), IL-10 (B), IL-6 (C) and TNF-alpha (D). Cytokines are stained with DAB (brown color) and counterstained with cresyl violet. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/23351591), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Rat IL-6 by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Rat IL-6 by Immunocytochemistry/ Immunofluorescence Diverse localization of measured cytokines in P7 brains. Representative pictures (100× magnification) of immunohistochemical stainings of IL-1 beta (Α), IL-10 (B), IL-6 (C) and TNF-alpha (D). Cytokines are stained with DAB (brown color) and counterstained with cresyl violet. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/23351591), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-6

Interleukin-6 (IL-6) is a pleiotropic, alpha -helical, phosphorylated and variably glycosylated cytokine that plays important roles in the acute phase reaction, inflammation, hematopoiesis, bone metabolism, and cancer progression. Mature rat IL-6 is 187 amino acids (aa) in length that is typically expressed as a 22-28 kDA molecular weight protein. Rat IL-6 shares 39% and 85% aa sequence identity with human and mouse IL-6, respectively. Alternative splicing generates several isoforms with internal deletions, some of which exhibit antagonistic properties. IL-6 induces signaling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6 R alpha) and a signal transducing subunit (gp130). IL-6 binds to IL-6 R alpha, triggering IL-6 R alpha association with gp130 and gp130 dimerization. gp130 is also a component of the receptors for CLC, CNTF, CT-1, IL-11, IL-27, LIF, and OSM. Soluble forms of IL-6 R alpha are generated by both alternative splicing and proteolytic cleavage. In a mechanism known as trans-signaling, complexes of soluble IL-6 and IL-6 R alpha elicit responses from gp130-expressing cells that lack cell surface IL-6 R alpha. Trans-signaling enables a wider range of cell types to respond to IL-6, as the expression of gp130 is ubiquitous, while that of IL-6 R alpha is predominantly restricted to hepatocytes, monocytes, and resting lymphocytes. Soluble splice forms of gp130 block trans-signaling from IL-6/IL-6 R alpha but not from other cytokines that use gp130 as a co-receptor. IL-6, along with TNF-alpha and IL-1, function to drive the acute inflammatory response and the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. When dysregulated, it contributes to chronic inflammation in obesity, insulin resistance, inflammatory bowel disease, arthritis, sepsis, and atherosclerosis. IL-6 can also function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise. In addition, it enhances hematopoietic stem cell proliferation and the differentiation of Th17 cells, memory B cells, and plasma cells.

Long Name
Interleukin 6
Entrez Gene IDs
3569 (Human); 16193 (Mouse); 24498 (Rat); 399500 (Porcine); 280826 (Bovine); 403985 (Canine); 102138971 (Cynomolgus Monkey); 100034196 (Equine); 493687 (Feline); 463288 (Primate); 100008733 (Rabbit)
Alternate Names
B-cell differentiation factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CTL differentiation factor ; HSF; hybridoma growth factor; IFNB2; IFN-beta-2; IL6; IL-6; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; interleukin-6; MGI-2A

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Citations for Rat IL-6 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

50 Citations: Showing 1 - 10
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  1. Amino acid sequence conservation of the algesic fragment of myelin basic protein is required for its interaction with CDK5 and function in pain
    Authors: Andrei V. Chernov, Albert G. Remacle, Swathi K. Hullugundi, Piotr Cieplak, Mila Angert, Jennifer Dolkas et al.
    The FEBS Journal
  2. Nuclear Factor kappa B Inhibition Reduces Lung Vascular Lumen Obliteration in Severe Pulmonary Hypertension in Rats
    Authors: Daniela Farkas, Aysar A. Alhussaini, Donatas Kraskauskas, Vita Kraskauskiene, Carlyne D. Cool, Mark R. Nicolls et al.
    American Journal of Respiratory Cell and Molecular Biology
  3. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
    Authors: Jinrui Dong, Sivakumar Viswanathan, Eleonora Adami, Sebastian Schafer, Fathima F Kuthubudeen, Anissa A Widjaja et al.
    eLife
  4. Investigations into Hypoxia and Oxidative Stress at the Optic Nerve Head in a Rat Model of Glaucoma
    Authors: Glyn Chidlow, John P. M. Wood, Robert J. Casson
    Frontiers in Neuroscience
  5. Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia
    Authors: Andrea V. Loureiro, Lauro I. Moura-Neto, Conceição S. Martins, Pedro I. M. Silva, Matheus B.S. Lopes, Renata F. C. Leitão et al.
    Frontiers in Immunology
  6. Metabolic Syndrome Exacerbates Pulmonary Hypertension due to Left Heart Disease
    Authors: Benoît Ranchoux, Valérie Nadeau, Alice Bourgeois, Steeve Provencher, Éve Tremblay, Junichi Omura et al.
    Circulation Research
  7. Adenine Nucleotide Translocase 1 Expression Modulates the Immune Response in Ischemic Hearts
    Authors: F Yergöz, J Friebel, N Kränkel, U Rauch-Kroe, HP Schultheis, U Landmesser, A Dörner
    Cells, 2021-08-19;10(8):.
  8. Interleukin 6 decreases nociceptor expression of the potassium channel KV1.4 in a rat model of hand–arm vibration syndrome
    Authors: Pedro Alvarez, Oliver Bogen, Jon D. Levine
    Pain
  9. Spinal activity of interleukin 6 mediates myelin basic protein-induced allodynia
    Authors: Justin S. Ko, Kelly A. Eddinger, Mila Angert, Andrei V. Chernov, Jennifer Dolkas, Alex Y. Strongin et al.
    Brain, Behavior, and Immunity
  10. Cerebellar Cytokine Expression in a Rat Model for Fetal Asphyctic Preconditioning and Perinatal Asphyxia
    Authors: Evi Vlassaks, Tomasz Brudek, Bente Pakkenberg, Antonio W. D. Gavilanes
    The Cerebellum
  11. Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction
    Authors: Marc Jonathan George, Nur Hayati Jasmin, Valerie Taylor Cummings, Angela Richard-Loendt, Francesca Launchbury, Kevin Woollard et al.
    JACC: Basic to Translational Science
  12. Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation
    Authors: M Leibinger, A Müller, P Gobrecht, H Diekmann, A Andreadaki, D Fischer
    Cell Death & Disease
  13. An unbiased proteomics approach to identify the senescence-associated secretory phenotype of human bone marrow-derived mesenchymal stem cells
    Authors: RM Samsonraj, SF Law, A Chandra, RJ Pignolo
    Bone Reports, 2023-03-21;18(0):101674.
    Species: Human
    Sample Types: Cell Culture Supernates
  14. Effects of Energy Drink Acute Assumption in Gastrointestinal Tract of Rats
    Authors: M Nasi, A De Gaetano, G Carnevale, L Bertoni, V Selleri, G Zanini, A Pisciotta, S Caramaschi, L Reggiani B, A Farinetti, A Cossarizza, M Pinti, A Manenti, AV Mattioli
    Nutrients, 2022-05-04;14(9):.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  15. Protective Effects of Growth Differentiation Factor-6 on the Intervertebral Disc: An In Vitro and In Vivo Study
    Authors: K Miyazaki, S Miyazaki, T Yurube, Y Takeoka, Y Kanda, Z Zhang, Y Kakiuchi, R Tsujimoto, H Ohnishi, T Matsuo, M Ryu, R Kuroda, K Kakutani
    Cells, 2022-03-31;11(7):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  16. Enhancing fractalkine/CX3CR1 signalling pathway can reduce neuroinflammation by attenuating microglia activation in experimental diabetic retinopathy
    Authors: M Jiang, H Xie, C Zhang, T Wang, H Tian, L Lu, JY Xu, GT Xu, L Liu, J Zhang
    Journal of Cellular and Molecular Medicine, 2022-01-11;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  17. Neuronal ApoE4 stimulates C/EBPbeta activation, promoting Alzheimer's disease pathology in a mouse model
    Authors: ZH Wang, Y Xia, Z Wu, SS Kang, JC Zhang, P Liu, X Liu, W Song, V Huin, CM Dhaenens, SP Yu, XC Wang, K Ye
    Progress in neurobiology, 2021-12-24;209(0):102212.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  18. Interleukin-6 promotes microtubule stability in axons via Stat3 protein-protein interactions
    Authors: Wareham LK, Echevarria FD, Sousa JL et al.
    iScience
  19. ApoE4 activates C/EBP&beta/&delta-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease
    Authors: ZH Wang, Y Xia, P Liu, X Liu, L Edgington-, K Lei, SP Yu, XC Wang, K Ye
    Progress in neurobiology, 2021-03-11;0(0):102032.
    Species: Rat
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Neutralization, Western Blot
  20. Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury
    Authors: S Zilberman-, R Abu-Hamad, R Zarura, M Sova, Y Hachmo, M Stark, S Neuman, S Slavin, S Efrati
    PLoS ONE, 2019-09-12;14(9):e0222354.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: Fuorescense Microscopy
  21. Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation
    Authors: M Yamamoto, M Kim, H Imai, Y Itakura, G Ohtsuki
    Cell Rep, 2019-09-10;28(11):2923-2938.e8.
    Species: Rat
    Sample Types: Tissue Culture Supernates
    Applications: Western Blot
  22. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBP? in Alzheimer's Disease
    Authors: ZH Wang, J Xiang, X Liu, SP Yu, FP Manfredsso, IM Sandoval, S Wu, JZ Wang, K Ye
    Cell Rep, 2019-07-16;28(3):655-669.e5.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  23. Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia
    Authors: H Ding, Y Dai, Y Lei, Z Wang, D Liu, R Li, L Shen, N Gu, M Zheng, X Zhu, G Zhao, Y Hu
    Cell. Mol. Immunol., 2018-11-28;0(0):.
    Species: Rat
    Sample Types: In Vivo
    Applications: Neutralization
  24. Baicalein attenuates neuropathic pain and improves sciatic nerve function recovery in rats with partial sciatic nerve transection
    Authors: HC Lai, CH Lu, CS Wong, BF Lin, SM Chan, CY Kuo, ZF Wu
    J Chin Med Assoc, 2018-08-20;0(0):.
    Species: Rat
    Sample Types: Whole Tissue
  25. Early CALP2 expression and microglial activation are potential inducers of spinal IL-6 upregulation and bilateral pain following motor nerve injury
    Authors: SX Chen, SK Wang, PW Yao, GJ Liao, XD Na, YY Li, WA Zeng, XG Liu, Y Zang
    J. Neurochem., 2018-04-01;0(0):.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  26. Intrinsic Inflammation Is a Potential Anti-Epileptogenic Target in the Organotypic Hippocampal Slice Model
    Authors: SA Chong, S Balosso, C Vandenplas, G Szczesny, E Hanon, K Claes, X Van Damme, B Danis, J Van Eyll, C Wolff, A Vezzani, RM Kaminski, I Niespodzia
    Neurotherapeutics, 2018-04-01;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  27. Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-? oligomers
    Authors: MA Godoy, LM Saraiva, LRP Carvalho, A Vasconcelo, HJV Beiral, AB Ramos, LRP Silva, RB Leal, VHS Monteiro, CV Braga, CA Araujo-Sil, LC Sinis, VB Santos, THK Brunswick, CL Alcantara, APCA Lima, NLD Cunha E Si, A Galina, A Vieyra, FG De Felice, R Mendez-Ote, ST Ferreira
    J. Biol. Chem., 2017-12-28;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  28. Repeated water avoidance stress induces visceral hypersensitivity; role of IL-1, IL-6 and peripheral corticotropin-releasing factor
    Authors: T Nozu, S Miyagishi, R Nozu, K Takakusaki, T Okumura
    J. Gastroenterol. Hepatol, 2017-12-01;0(0):.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  29. Mu-opioid receptor and delta-opioid receptor differentially regulate microglial inflammatory response to control proopiomelanocortin neuronal apoptosis in the hypothalamus: effects of neonatal alcohol
    Authors: P Shrivastav, MA Cabrera, LG Chastain, NI Boyadjieva, S Jabbar, T Franklin, DK Sarkar
    J Neuroinflammation, 2017-04-14;14(1):83.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  30. Electrical stimulation induces IL-6 in skeletal muscle through extracellular ATP by activating Ca(2+) signals and an IL-6 autocrine loop.
    Authors: Bustamante M, Fernandez-Verdejo R, Jaimovich E, Buvinic S
    Am J Physiol Endocrinol Metab, 2014-02-11;306(8):E869-82.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  31. Microglia enhance neurogenesis and oligodendrogenesis in the early postnatal subventricular zone.
    Authors: Shigemoto-Mogami Y, Hoshikawa K, Goldman J, Sekino Y, Sato K
    J Neurosci, 2014-02-05;34(6):2231-43.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  32. Mechanisms involved in dual vasopressin/apelin neuron dysfunction during aging.
    Authors: Sauvant J, Delpech J, Palin K, De Mota N, Dudit J, Aubert A, Orcel H, Roux P, Laye S, Moos F, Llorens-Cortes C, Nadjar A
    PLoS ONE, 2014-02-05;9(2):e87421.
    Species: Rat
    Sample Types: In Vivo
    Applications: Neutralization
  33. Sublytic C5b-9 induces IL-6 and TGF-beta1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPbeta acetylation.
    Authors: Zhang J, Li Y, Shan K, Wang L, Qiu W, Lu Y, Zhao D, Zhu G, He F, Wang Y
    FASEB J, 2013-12-16;28(3):1511-25.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Synergistic induction of interferon alpha through TLR-3 and TLR-9 agonists identifies CD21 as interferon alpha receptor for the B cell response.
    Authors: Kim D, Niewiesk S
    PLoS Pathog, 2013-03-14;9(3):e1003233.
    Species: Rat
    Sample Types: Cell Culture Supernates
    Applications: Neutralization
  35. Serum-starved adipose-derived stromal cells ameliorate crescentic GN by promoting immunoregulatory macrophages.
    Authors: Furuhashi, Kazuhiro, Tsuboi, Naotake, Shimizu, Asuka, Katsuno, Takayuki, Kim, Hangsoo, Saka, Yosuke, Ozaki, Takenori, Sado, Yoshikaz, Imai, Enyu, Matsuo, Seiichi, Maruyama, Shoichi
    J Am Soc Nephrol, 2013-03-07;24(4):587-603.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  36. Fetal asphyctic preconditioning modulates the acute cytokine response thereby protecting against perinatal asphyxia in neonatal rats.
    Authors: Vlassaks E, Strackx E, Vles J, Nikiforou M, Martinez-Martinez P, Kramer B, Gavilanes A
    J Neuroinflammation, 2013-01-26;10(0):14.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  37. Astrocyte-derived interleukin-6 promotes specific neuronal differentiation of neural progenitor cells from adult hippocampus.
    Authors: Oh J, McCloskey MA, Blong CC
    J. Neurosci. Res., 2010-10-01;88(13):2798-809.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  38. Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed-onset muscle soreness).
    Authors: Murase S, Terazawa E, Queme F, Ota H, Matsuda T, Hirate K, Kozaki Y, Katanosaka K, Taguchi T, Urai H, Mizumura K
    J. Neurosci., 2010-03-10;30(10):3752-61.
    Species: Rat
    Sample Types: In Vivo
    Applications: Neutralization
  39. JAK/STAT3 pathway is activated in spinal cord microglia after peripheral nerve injury and contributes to neuropathic pain development in rat.
    Authors: Dominguez E, Rivat C, Pommier B, Mauborgne A, Pohl M
    J. Neurochem., 2008-07-12;107(1):50-60.
    Species: Rat
    Sample Types: In Vivo
    Applications: Neutralization
  40. Trauma and hemorrhage-induced acute hepatic insulin resistance: dominant role of tumor necrosis factor-alpha.
    Authors: Xu J, Kim HT, Ma Y, Zhao L, Zhai L, Kokorina N, Wang P, Messina JL
    Endocrinology, 2008-01-10;149(5):2369-82.
    Species: Rat
    Sample Types: In Vivo
    Applications: Neutralization
  41. Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells.
    Authors: Nakanishi M, Niidome T, Matsuda S, Akaike A, Kihara T, Sugimoto H
    Eur. J. Neurosci., 2007-02-01;25(3):649-58.
    Species: Rat
    Sample Types: Cell Culture Supernates
    Applications: Immunodepletion
  42. Identification of astrocyte-expressed factors that modulate neural stem/progenitor cell differentiation.
    Authors: Barkho BZ, Song H, Aimone JB
    Stem Cells Dev., 2006-06-01;15(3):407-21.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  43. Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage.
    Authors: Yang S, Hu S, Hsieh YC, Choudhry MA, Rue LW, Bland KI, Chaudry IH
    J. Mol. Cell. Cardiol., 2006-02-24;40(4):570-9.
    Species: Rat
    Sample Types:
    Applications: Neutralization
  44. Renal denervation reduces atrial remodeling in hypertensive rats with metabolic syndrome
    Authors: Simina-Ramona Selejan, Dominik Linz, Muriel Mauz, Mathias Hohl, Anh Khoa Dennis Huynh, Thimoteus Speer et al.
    Basic Research in Cardiology
  45. Interleukin-6 promotes microtubule stability in axons via Stat3 protein-protein interactions
    Authors: Wareham LK, Echevarria FD, Sousa JL et al.
    iScience
  46. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH
    Authors: J Dong, S Viswanatha, E Adami, BK Singh, SP Chothani, B Ng, WW Lim, J Zhou, M Tripathi, NSJ Ko, SG Shekeran, J Tan, SY Lim, M Wang, PM Lio, PM Yen, S Schafer, SA Cook, AA Widjaja
    Nature Communications, 2021-01-04;12(1):66.
  47. Adenosine receptors differentially mediate enteric glial cell death induced by Clostridioides difficile Toxins A and B
    Authors: Costa DVS, Shin JH, Goldbeck SM et al.
    Frontiers in immunology
  48. Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury
    Authors: Yujun Luo, Beibei Wang, Jianhua Liu, Faxin Ma, Dongling Luo, Zhongwen Zheng et al.
    Aging (Albany NY)
  49. Spinal cord injury and its underlying mechanism in rats with temporal lobe epilepsy
    Authors: Jinjie Liu, Zanhua Liu, Guoliang Liu, Kai Gao, Hengjie Zhou, Yongbo Zhao et al.
    Experimental and Therapeutic Medicine
  50. Pyruvate kinase M2 (PKM2) improve symptoms of post‐ischemic stroke depression by activating VEGF to mediate the MAPK/ERK pathway
    Authors: Yun Feng, Xuebin Li, Jie Wang, Xiaohua Huang, Lanqing Meng, Jianmin Huang
    Brain and Behavior

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