TIM-3: Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
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"TIM-3" has 22 results in Products.
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Proteome Profiler Human XL Cytokine Array Kit
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
Human TIM-3 Alexa Fluor® 488-conjugated Antibody
Clone 344823 was used by HLDA to establish CD designation
Human TIM-3 Alexa Fluor® 700-conjugated Antibody
Clone 344823 was used by HLDA to establish CD designation
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