Proteome Profiler Human Angiogenesis Array Kit
Proteome Profiler Human Angiogenesis Array Kit Summary
A membrane-based antibody array for the parallel determination of the relative levels of selected angiogenesis-related proteins. Validated for analyte detection in cell culture supernates, cell lysates, tissue lysates, serum, plasma and saliva.
Key Benefits
- Detects 55 human angiogenesis-related proteins simultaneously
- Requires no specialized equipment
- Compatible with LI-COR* and chemiluminescence detection
Principle of the Assay
The Proteome Profiler Human Angiogenesis Array Kit is a membrane-based sandwich immunoassay. Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2). Captured proteins are visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of bound analyte. Analytes include soluble growth and differentiation factors, extracellular matrix components, proteases, membrane-bound receptors, and intracellular signaling molecules.
Why Use an Antibody Array to Detect Angiogenesis-Related Proteins?
Determining the expression of multiple proteins in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple proteins in a single sample can be cost-effective and also save time and sample.
- 4 Array Membranes
- 4-Well Multi-dish
- Array Buffers
- Wash Buffer
- Antibody Detection Cocktail
- Streptavidin-HRP
- Chemiluminescent Detection Reagents
- Transparency Overlay Template
- Detailed Protocol
For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.
Stability and Storage
Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.
Simultaneously detect the relative levels of these angiogenesis-related proteins in a single sample. | ||
Activin A | FGF-7/KGF | PD-ECGF |
ADAMTS-1 | GDNF | PDGF-AA |
Angiogenin | GM-CSF | PDGF-AB/PDGF-BB |
Angiopoietin-1 | HB-EGF | Persephin |
Angiopoietin-2 | HGF | CXCL4/PF4 |
Angiostatin/Plasminogen | IGFBP-1 | PlGF |
Amphiregulin | IGFBP-2 | Prolactin |
Artemin | IGFBP-3 | Serpin B5/Maspin |
Tissue Factor/Factor III | IL-1 beta | Serpin E1/PAI-1 |
CXCL16 | CXCL8/IL-8 | Serpin F1/PEDF |
DPPIV/CD26 | LAP (TGF-beta 1) | TIMP-1 |
EGF | Leptin | TIMP-4 |
EG-VEGF | CCL2/MCP-1 | Thrombospondin-1 |
Endoglin/CD105 | CCL3/MIP-1 alpha | Thrombospondin-2 |
Endostatin/Collagen XVIII | MMP-8 | uPA |
Endothelin-1 | MMP-9 | Vasohibin |
FGF acidic | NRG1-beta 1 | VEGF |
FGF basic | Pentraxin 3 | VEGF-C |
FGF-4 |
Assays for analytes represented in the Human Angiogenesis Antibody Array Kit
Quantikine® ELISA Kits | DuoSet® ELISA Development Systems | Quantikine® HS (High Sensitivity) ELISA Kits | QuantiGlo® Chemiluminescent ELISA Kits | |
Activin A | DAC00B | DY338 | ||
ADAMTS-1 | DY2197 | |||
Angiogenin | DAN00 | DY265 | ||
Angiopoietin-1 | DANG10 | DY923 | ||
Angiopoietin-2 | DANG20 | DY623 | ||
Angiostatin/Plasminogen | ||||
Amphiregulin | DY262 | |||
Artemin | DY2589 | |||
Tissue Factor/Factor III | DCF300 | DY2339 | ||
CXCL16 | DCX160 | DY1164 | ||
DPPIV/CD26 | DY1180 | |||
EGF | DEG00 | DY236 | ||
EG-VEGF | DY1209 | |||
Endoglin | DNDG00 | DY1097 | ||
Endostatin/Collagen XVII | DNST0 | DY1098 | ||
Endothelin-1 | DET100 | QET00B | ||
FGF acidic | DFA00B | DY232 | ||
FGF basic | DFB50 | DY233 | HSFB00D | |
FGF-4 | DY235 | |||
FGF-7/KGF | DKG00 | DY251 | ||
GDNF | DY212 | |||
GM-CSF | DGM00 | DY215 | HSGM0 | |
HB-EGF | DY259 | |||
HGF | DHG00 | DY294 | ||
IGFBP-1 | DY871 | |||
IGFBP-2 | DGB200 | DY674 | ||
IGFBP-3 | DGB300 | DY675 | ||
IL-1 beta | DLB50 | DY201 | HSLB00D | QLB00B |
CXCL8/IL-8 | D8000C | DY208 | HS800 | Q8000B |
TGF-beta1 (LAP) | DB100B | DY240 | ||
Leptin | DLP00 | DY398 | ||
CCL2/MCP-1 | DCP00 | DY279 | ||
CCL3/MIP-1 alpha | DMA00 | DY270 | ||
MMP-8 | DMP800 | DY908 | ||
MMP-9 | DMP900 | DY911 | ||
NRG1-beta1 | DY377 | |||
Pentraxin 3 | DPTX30 | DY1826 | ||
PD-ECGF | ||||
PDGF-AA | DAA00B | DY221 | ||
PDGF-AB/PDGF-BB | DHD00C, DBB00 | DY222, DY220 | ||
Persephin | ||||
CXCL4/PF4 | DY795 | |||
PlGF | DPG00 | DY264 | ||
Prolactin | DPRL00 | DY682 | ||
Serpin B5/Maspin | ||||
Serpin E1/PAI-1 | DSE100 | DY1786 | ||
Serpin F1/PEDF | ||||
TIMP-1 | DTM100 | DY970 | ||
TIMP-4 | DTM400 | DY974 | ||
Thrombospondin-1 | DTSP10 | DY3074 | ||
Thrombospondin-2 | DTSP20 | DY1635 | ||
uPA | DUPA00 | DY1310 | ||
Vasohibin | ||||
VEGF | DVE00 | DY293B | QVE00B | |
VEGF-C | DVEC00 | DY752B |
Specifications
Product Datasheets
Scientific Data
Profiling Angiogenesis-Related Proteins in Human Cancer Tissues. A) The Proteome Profiler Human Angiogenesis Antibody Array (Catalog # ARY007) was used to profile angiogenesis-related proteins in tissues from human prostate, ovarian, and breast cancers. B) Histogram profiles for select analytes were generated by quantifying the mean spot pixel densities from the array membrane using image software.
The Human Angiogenesis Array detects multiple analytes in cell culture supernates. A. THP-1 human acute monocytic leukemia cell line treated with 1 µg/mL Recombinant Human IFN-gamma (Catalog # 285-IF) for 8 hours and 1 µg/mL lipopolysaccharide (LPS) for 16 hours. B. HUVEC human umbilical vein endothelial cells treated with 10 mg/ml of LPS for 24 hours. 500 µL of supernate was used for each array shown. Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.
The Human Angiogenesis Array detects multiple analytes in tissue lysate, serum, and plasma. Representative membranes and selective quantification are shown for human ovarian cancer tissue lysate (A., 200 µg), serum (B., 100 µL), and EDTA plasma (C., 100 µL). Array images were collected and analyzed using the LI-COR Odyssey Infrared Imaging System.
Citations for Proteome Profiler Human Angiogenesis Array Kit
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Heme: A link between hemorrhage and retinopathy of prematurity progression
Authors: Gáll, T;Peth?, D;Erdélyi, K;Egri, V;Balla, JG;Nagy, A;Nagy, A;Póliska, S;Gram, M;Gábriel, R;Nagy, P;Balla, J;Balla, G;
Redox biology 2024-10-01
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Molecular and Functional Cargo of Plasma-Derived Exosomes in Patients with Hereditary Hemorrhagic Telangiectasia
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Prevascularized spongy-like hydrogels maintain their angiogenic potential after prolonged hypothermic storage
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Bioactive materials 2024-07-01
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Expression of hsa-miRNA-15b, -99b, -181a and Their Relationship to Angiogenesis in Renal Cell Carcinoma
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Mitochondrial transfer mediates endothelial cell engraftment through mitophagy
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Nature 2024-05-01
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PP2A Affects Angiogenesis via Its Interaction with a Novel Phosphorylation Site of TSP1
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International journal of molecular sciences 2024-02-03
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The Effects of Preeclamptic Milieu on Cord Blood Derived Endothelial Colony-Forming Cells
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Effects of an Adipose Mesenchymal Stem Cell-Derived Conditioned medium and TGF-?1 on Human Keratinocytes In Vitro
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Combination of Phenethyl Isothiocyanate and Dasatinib Inhibits Hepatocellular Carcinoma Metastatic Potential through FAK/STAT3/Cadherin Signalling and Reduction of VEGF Secretion
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The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson's disease
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Augmenting the Angiogenic Profile and Functionality of Cord Blood Endothelial Colony-Forming Cells by Indirect Priming with Bone-Marrow-Derived Mesenchymal Stromal Cells
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Liver X Receptor Agonist Inhibits Oxidized Low-Density Lipoprotein Induced Choroidal Neovascularization via the NF-kappaB Signaling Pathway
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The D405N Mutation in the Spike Protein of SARS-CoV-2 Omicron BA.5 Inhibits Spike/Integrins Interaction and Viral Infection of Human Lung Microvascular Endothelial Cells
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Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis
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Proceedings of the National Academy of Sciences of the United States of America, 2022-12-27;120(1):e2208541120. 2022-12-27
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RNF213 Loss-of-Function Promotes Angiogenesis of Cerebral Microvascular Endothelial Cells in a Cellular State Dependent Manner
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Secretome from human adipose-derived mesenchymal stem cells promotes blood vessel formation and pericyte coverage in experimental skin repair
Authors: BM Silveira, TO Ribeiro, RS Freitas, ACO Carreira, MS Gonçalves, M Sogayar, R Meyer, A Birbrair, V Fortuna
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PARP Inhibitor Inhibits the Vasculogenic Mimicry through a NF-kappaB-PTX3 Axis Signaling in Breast Cancer Cells
Authors: J Chivot, N Ferrand, A Fert, P Van Dreden, R Morichon, M Sabbah
International Journal of Molecular Sciences, 2022-12-18;23(24):. 2022-12-18
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Growth Factor-Free Vascularization of Marine-Origin Collagen Sponges Using Cryopreserved Stromal Vascular Fractions from Human Adipose Tissue
Authors: S Freitas-Ri, GS Diogo, C Oliveira, A Martins, TH Silva, M Jarnalo, R Horta, RL Reis, RP Pirraco
Marine Drugs, 2022-09-30;20(10):. 2022-09-30
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The Stability and Anti-Angiogenic Properties of Titanium Dioxide Nanoparticles (TiO2NPs) Using Caco-2 Cells
Authors: OM David, KL Lategan, MF de Cortale, EJ Pool
Biomolecules, 2022-09-21;12(10):. 2022-09-21
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MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer
Authors: Y Gao, Y Fang, Y Huang, R Ma, X Chen, F Wang, X Pei, Y Gao, X Chen, X Liu, J Shan, P Li
Cell Death & Disease, 2022-09-21;13(9):810. 2022-09-21
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Overexpression of mir-135b and mir-210 in mesenchymal stromal cells for the enrichment of extracellular vesicles with angiogenic factors
Authors: JMF Vieira, LN Zamproni, CHC Wendt, K Rocha de M, RS Lindoso, S Won Han
PLoS ONE, 2022-08-16;17(8):e0272962. 2022-08-16
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Angiogenic Potential of Co-Cultured Human Umbilical Vein Endothelial Cells and Adipose Stromal Cells in Customizable 3D Engineered Collagen Sheets
Authors: P Nessbach, S Schwarz, TD Becke, H Clausen-Sc, HG Machens, S Sudhop
Journal of functional biomaterials, 2022-07-29;13(3):. 2022-07-29
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WNK1 collaborates with TGF-beta in endothelial cell junction turnover and angiogenesis
Authors: AB Jaykumar, S Plumber, DM Barry, D Binns, C Wichaidit, M Grzemska, S Earnest, EJ Goldsmith, O Cleaver, MH Cobb
Proceedings of the National Academy of Sciences of the United States of America, 2022-07-22;119(30):e2203743119. 2022-07-22
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Two New Potential Therapeutic Approaches in Radiation Cystitis Derived from Mesenchymal Stem Cells: Extracellular Vesicles and Conditioned Medium
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Biology, 2022-06-28;11(7):. 2022-06-28
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Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood-brain barrier function
Authors: BS Casas, G Vitória, CP Prieto, M Casas, C Chacón, M Uhrig, F Ezquer, M Ezquer, SK Rehen, V Palma
Molecular Psychiatry, 2022-06-15;0(0):. 2022-06-15
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Development of secretome-based strategies to improve cell culture protocols in tissue engineering
Authors: O Cases-Pere, C Blanco-Eli, J Chato-Astr, C Miranda-Fe, F Campos, PV Crespo, I Sánchez-Mo, M Alaminos, MA Martín-Pie, I Garzón
Oncogene, 2022-06-15;12(1):10003. 2022-06-15
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FASN promotes lymph node metastasis in cervical cancer via cholesterol reprogramming and lymphangiogenesis
Authors: Q Du, P Liu, C Zhang, T Liu, W Wang, C Shang, J Wu, Y Liao, Y Chen, J Huang, H Tan, Y Zhao, M Xia, J Liu, S Yao
Cell Death & Disease, 2022-05-21;13(5):488. 2022-05-21
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The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2
Authors: M Ehsani, S Bartsch, SMM Rasa, J Dittmann, T Pungsrinon, L Neubert, SS Huettner, R Kotolloshi, K Schindler, A Ahmad, AS Mosig, L Adam, A Ori, F Neri, A Berndt, MO Grimm, A Baniahmad
Oncogene, 2022-05-05;0(0):. 2022-05-05
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Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects
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Cancer Medicine, 2022-04-17;0(0):. 2022-04-17
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A novel mechanism for A-to-I RNA-edited AZIN1 in promoting tumor angiogenesis in colorectal cancer
Authors: Y Wei, H Zhang, Q Feng, S Wang, Y Shao, J Wu, G Jin, W Lin, X Peng, X Xu
Cell Death & Disease, 2022-04-02;13(4):294. 2022-04-02
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SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an alphavbeta3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing Antibodies
Authors: A Bugatti, F Filippini, M Bardelli, A Zani, P Chiodelli, S Messali, A Caruso, F Caccuri
Viruses, 2022-03-29;14(4):. 2022-03-29
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Strategy for improving cell-mediated vascularized soft tissue formation in a hydrogen peroxide-triggered chemically-crosslinked hydrogel
Authors: SY Wei, TH Chen, FS Kao, YJ Hsu, YC Chen
Journal of tissue engineering, 2022-03-11;13(0):2041731422108. 2022-03-11
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PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients
Authors: Y Qin, J Zhang, S Babapoor-F, B Applewhite, M Deshpande, H Megarity, M Flores-Bel, S Aparicio-D, T Ma, Y Rui, SY Tzeng, JJ Green, MV Canto-Sole, S Montaner, A Sodhi
Science Advances, 2022-03-02;8(9):eabm1896. 2022-03-02
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Staphylococcus aureus beta-Toxin Exerts Anti-angiogenic Effects by Inhibiting Re-endothelialization and Neovessel Formation
Authors: PM Tran, SS Tang, W Salgado-Pa
Frontiers in Microbiology, 2022-02-03;13(0):840236. 2022-02-03
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Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction
Authors: I Marei, O Chidiac, B Thomas, J Pasquier, S Dargham, A Robay, M Vakayil, M Jameesh, C Triggle, A Rafii, A Jayyousi, J Al Suwaidi, C Abi Khalil
Cardiovascular Diabetology, 2022-02-02;21(1):17. 2022-02-02
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Secretome from Human Mesenchymal Stem Cells-Derived Endothelial Cells Promotes Wound Healing in a Type-2 Diabetes Mouse Model
Authors: V Ormazabal, E Nova-Lampe, D Rojas, FA Zúñiga, C Escudero, P Lagos, A Moreno, Y Pavez, C Reyes, M Yáñez, M Vidal, G Cabrera-Vi, K Oporto, C Aguayo
International Journal of Molecular Sciences, 2022-01-15;23(2):. 2022-01-15
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High glucose induced inflammation is inhibited by copper chelation via rescuing mitochondrial fusion protein 2 in retinal pigment epithelial cells
Authors: M Aloysius D, KN Sulochana, SRB Devi
Cellular Signalling, 2022-01-06;0(0):110244. 2022-01-06
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Lightwave-reinforced stem cells with enhanced wound healing efficacy
Authors: YJ Kim, HR Jeon, SW Kim, YH Kim, GB Im, J Im, SH Um, SM Cho, JR Lee, HY Kim, YK Joung, DI Kim, SH Bhang
Journal of tissue engineering, 2021-12-18;12(0):2041731421106. 2021-12-18
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Nano-Sized Extracellular Matrix Particles Lead to Therapeutic Improvement for Cutaneous Wound and Hindlimb Ischemia
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International Journal of Molecular Sciences, 2021-12-09;22(24):. 2021-12-09
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Evaluating the Effect of Lenvatinib on Sorafenib-Resistant Hepatocellular Carcinoma Cells
Authors: T Shi, H Iwama, K Fujita, H Kobara, N Nishiyama, S Fujihara, Y Goda, H Yoneyama, A Morishita, J Tani, M Yamada, M Nakahara, K Takuma, T Masaki
International Journal of Molecular Sciences, 2021-12-02;22(23):. 2021-12-02
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The Regeneration of Large-Sized and Vascularized Adipose Tissue Using a Tailored Elastic Scaffold and dECM Hydrogels
Authors: SH Kim, D Kim, M Cha, SH Kim, Y Jung
International Journal of Molecular Sciences, 2021-11-22;22(22):. 2021-11-22
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MMP9 secreted from mononuclear cell quality and quantity culture mediates STAT3 phosphorylation and fibroblast migration in wounds
Authors: T Nishikai-Y, M Kado, H Hagiwara, S Fujimura, H Mizuno, R Tanaka
Regenerative Therapy, 2021-11-04;18(0):464-471. 2021-11-04
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CMAHP promotes metastasis by reducing ubiquitination of Snail and inducing angiogenesis via GM-CSF overexpression in gastric cancer
Authors: HW Huang, CY Chen, YH Huang, CT Yeh, CS Wang, CC Chang, KH Lin
Oncogene, 2021-10-29;0(0):. 2021-10-29
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ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype
Authors: H Sheldon, J Alexander, E Bridges, L Moreira, S Reilly, KH Ang, D Wang, S Lin, S Haider, AH Banham, AL Harris
International Journal of Molecular Sciences, 2021-10-19;22(20):. 2021-10-19
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LTBP4 affects renal fibrosis by influencing angiogenesis and altering mitochondrial structure
Authors: CT Su, TM Jao, Z Urban, YJ Huang, DHW See, YC Tsai, WC Lin, JW Huang
Cell Death & Disease, 2021-10-13;12(10):943. 2021-10-13
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Eicosanoid regulation of debris-stimulated metastasis
Authors: J Deng, H Yang, VM Haak, J Yang, FC Kipper, C Barksdale, SH Hwang, A Gartung, DR Bielenberg, S Subbian, KK Ho, X Ye, D Fan, Y Sun, BD Hammock, D Panigrahy
Proceedings of the National Academy of Sciences of the United States of America, 2021-10-12;118(41):. 2021-10-12
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Dexamethasone enhances the efficacy of atorvastatin in inhibiting excessively inflammation-induced abnormal angiogenesis by regulating macrophages
Authors: Z Gong, D Zhan, M Nie, X Li, C Gao, X Liu, T Xiang, J Yuan, W Jiang, J Huang, W Quan, D Wang, Y Tian, H Yuan, J Zhang, R Jiang
Journal of Neuroinflammation, 2021-09-15;18(1):203. 2021-09-15
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Identification of soluble tissue-derived biomarkers from human thyroid tissue explants maintained on a microfluidic device
Authors: A Riley, H Jones, J England, D Kuvshinov, V Green, J Greenman
Oncology Letters, 2021-09-13;22(5):780. 2021-09-13
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Construction of transplantable artificial vascular tissue based on adipose tissue-derived mesenchymal stromal cells by a cell coating and cryopreservation technique
Authors: Y Asano, D Okano, M Matsusaki, T Watabe, Y Yoshimatsu, M Akashi, H Shimoda
Scientific Reports, 2021-09-09;11(1):17989. 2021-09-09
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CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
Authors: S Ma, LS Mangala, W Hu, E Bayaktar, A Yokoi, W Hu, S Pradeep, S Lee, PD Piehowski, A Villar-Pra, SY Wu, MH McGuire, OD Lara, C Rodriguez-, CJ LaFargue, NB Jennings, KD Rodland, T Liu, V Kundra, PT Ram, S Ramakrishn, G Lopez-Bere, RL Coleman, AK Sood
Cell Reports, 2021-08-17;36(7):109549. 2021-08-17
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Keratin-Alginate Sponges Support Healing of Partial-Thickness Burns
Authors: ZK Moay, LTH Nguyen, P Hartrianti, DP Lunny, D Leavesley, YO Kok, SJ Chong, AWC Chua, SI Tee, KW Ng
International Journal of Molecular Sciences, 2021-08-10;22(16):. 2021-08-10
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Systems analysis identifies endothelin 1 axis blockade for enhancing the anti-tumor effect of multikinase inhibitor
Authors: CY Hwang, SJ Yu, JK Won, SM Park, H Noh, S Lee, EJ Cho, JH Lee, KB Lee, YJ Kim, KS Suh, JH Yoon, KH Cho
Cancer Gene Therapy, 2021-08-06;0(0):. 2021-08-06
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SARS-CoV-2 Infection Remodels the Phenotype and Promotes Angiogenesis of Primary Human Lung Endothelial Cells
Authors: F Caccuri, A Bugatti, A Zani, A De Palma, D Di Silvest, E Manocha, F Filippini, S Messali, P Chiodelli, G Campisi, S Fiorentini, F Facchetti, P Mauri, A Caruso
Microorganisms, 2021-07-03;9(7):. 2021-07-03
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Serum-Derived Small Extracellular Vesicles From Diabetic Mice Impair Angiogenic Property of Microvascular Endothelial Cells: Role of EZH2
Authors: Z Cheng, V Naga Srika, MM Truongcao, M Cimini, G Huang, C Wang, C Benedict, C Gonzalez, V Mallaredy, DA Goukassian, SK Verma, R Kishore
Journal of the American Heart Association, 2021-05-14;10(10):e019755. 2021-05-14
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Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes
Authors: E Nassar, N Hassan, EA El-Ghonaim, H Hassan, MS Abdullah, TV Rottke, L Kiesel, B Greve, SA Ibrahim, M Götte
Cancers, 2021-05-12;13(10):. 2021-05-12
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Low RECK Expression Is Part of the Cervical Carcinogenesis Mechanisms
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Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles
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International Journal of Molecular Sciences, 2021-04-09;22(8):. 2021-04-09
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Regenerative Therapy, 2021-03-27;18(0):38-50. 2021-03-27
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Syndecan-1 Overexpressing Mesothelioma Cells Inhibit Proliferation, Wound Healing, and Tube Formation of Endothelial Cells
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The ER stress response mediator ERO1 triggers cancer metastasis by favoring the angiogenic switch in hypoxic conditions
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Oncogene, 2021-02-02;0(0):. 2021-02-02
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RUNX3 Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis
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Ricinus communis Butanol Fraction Inhibits MCF-7 Breast Cancer Cell Migration, Adhesion, and Invasiveness
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Integrative cancer therapies, 2021-01-01;20(0):1534735420977. 2021-01-01
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In vitro modeling of solid tumor interactions with perfused blood vessels
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Sci Rep, 2020-11-19;10(1):20142. 2020-11-19
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Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel model
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J Neuroinflammation, 2020-11-18;17(1):346. 2020-11-18
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Human mesenchymal stromal/stem cells recruit resident pericytes and induce blood vessels maturation to repair experimental spinal cord injury in rats
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Sci Rep, 2020-11-11;10(1):19604. 2020-11-11
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FEBS Open Bio, 2020-11-09;0(0):. 2020-11-09
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PLoS ONE, 2020-10-29;15(10):e0241423. 2020-10-29
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Occurrence of Fibrotic Tumor Vessels in Grade I Meningiomas Is Strongly Associated with Vessel Density, Expression of VEGF, PlGF, IGFBP-3 and Tumor Recurrence
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Cancers (Basel), 2020-10-21;12(10):. 2020-10-21
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Bioact Mater, 2020-09-01;6(2):326-332. 2020-09-01
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Decidual glycodelin-A polarizes human monocytes towards a decidual macrophage-like phenotype via siglec-7
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J. Cell. Sci., 2020-07-23;0(0):. 2020-07-23
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Resveratrol Promotes Tumor Microvessel Growth via Endoglin and Extracellular Signal-Regulated Kinase Signaling Pathway and Enhances the Anticancer Efficacy of Gemcitabine against Lung Cancer
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Cancers (Basel), 2020-04-15;12(4):. 2020-04-15
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Human Peripheral Blood-Derived Endothelial Colony-Forming Cells Are Highly Similar to Mature Vascular Endothelial Cells yet Demonstrate a Transitional Transcriptomic Signature
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Cells, 2020-04-03;9(4):. 2020-04-03
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Metastasis-associated fibroblasts promote angiogenesis in metastasized pancreatic cancer via the CXCL8 and the CCL2 axes
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Sci Rep, 2020-03-25;10(1):5420. 2020-03-25
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DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-&kappaB and sensitize to alkylating chemotherapy
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BMC Biol., 2020-03-24;18(1):32. 2020-03-24
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An Active and Soft Hydrogel Actuator to Stimulate Live Cell Clusters by Self-folding
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Polymers (Basel), 2020-03-05;12(3):. 2020-03-05
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Secretome of Senescent Adipose-Derived Mesenchymal Stem Cells Negatively Regulates Angiogenesis
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Int J Mol Sci, 2020-03-05;21(5):. 2020-03-05
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Helicobacter Pylori Targets the EPHA2 Receptor Tyrosine Kinase in Gastric Cells Modulating Key Cellular Functions
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Cells, 2020-02-24;9(2):. 2020-02-24
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ECM Mimetic Electrospun Porous Poly (L-lactic acid) (PLLA) Scaffolds as Potential Substrates for Cardiac Tissue Engineering
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Polymers (Basel), 2020-02-14;12(2):. 2020-02-14
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HB-EGF-EGFR Signaling in Bone Marrow Endothelial Cells Mediates Angiogenesis Associated with Multiple Myeloma
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Cancers (Basel), 2020-01-10;12(1):. 2020-01-10
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Proteomic Profiling Reveals the Ambivalent Character of the Mesenchymal Stem Cell Secretome: Assessing the Effect of Preconditioned Media on Isolated Human Islets
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Cell Transplant, 2020-01-01;29(0):9636897209523. 2020-01-01
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Hematoma-derived exosomes of chronic subdural hematoma promote abnormal angiogenesis and inhibit hematoma absorption through miR-144-5p
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Aging (Albany NY), 2019-12-16;11(24):12147-12164. 2019-12-16
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The efficacy of conditioned medium released by tonsil-derived mesenchymal stem cells in a chronic murine colitis model
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PLoS ONE, 2019-12-02;14(12):e0225739. 2019-12-02
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Natural Histogel-Based Bio-Scaffolds for Sustaining Angiogenesis in Beige Adipose Tissue
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Cells, 2019-11-18;8(11):. 2019-11-18
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Patient-Specific iPSC Model of a Genetic Vascular Dementia Syndrome Reveals Failure of Mural Cells to Stabilize Capillary Structures
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Stem Cell Reports, 2019-10-31;13(5):817-831. 2019-10-31
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B-Cell Activating Factor Enhances Hepatocyte-Driven Angiogenesis via B-Cell CLL/Lymphoma 10/Nuclear Factor-KappaB Signaling during Liver Regeneration
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Int J Mol Sci, 2019-10-10;20(20):. 2019-10-10
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TGFBI Protein Is Increased in the Urine of Patients with High-Grade Urothelial Carcinomas, and Promotes Cell Proliferation and Migration
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Int J Mol Sci, 2019-09-11;20(18):. 2019-09-11
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Harnessing Induced Essentiality: Targeting Carbonic Anhydrase IX and Angiogenesis Reduces Lung Metastasis of Triple Negative Breast Cancer Xenografts
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Cancers (Basel), 2019-07-17;11(7):. 2019-07-17
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Telmisartan Inhibits Cell Proliferation and Tumor Growth of Esophageal Squamous Cell Carcinoma by Inducing S-Phase Arrest In Vitro and In Vivo
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Int J Mol Sci, 2019-06-29;20(13):. 2019-06-29
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Characterization of the Angiogenic Potential of Human Regulatory Macrophages (Mreg) after Ischemia/Reperfusion Injury In Vitro
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Stem Cells Int, 2019-06-25;2019(0):3725863. 2019-06-25
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Extracellular Nanovesicles Secreted by Human Osteosarcoma Cells Promote Angiogenesis
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Cancers (Basel), 2019-06-05;11(6):. 2019-06-05
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Impaired Regeneration Potential in Urinary Stem Cells Diagnosed from the Patients with Diabetic Nephropathy
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Theranostics, 2019-05-31;9(14):4221-4232. 2019-05-31
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Thrombin Preconditioning of Extracellular Vesicles Derived from Mesenchymal Stem Cells Accelerates Cutaneous Wound Healing by Boosting Their Biogenesis and Enriching Cargo Content
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J Clin Med, 2019-04-18;8(4):. 2019-04-18
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The Composition of Hyperacute Serum and Platelet-Rich Plasma Is Markedly Different despite the Similar Production Method
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Int J Mol Sci, 2019-02-08;20(3):. 2019-02-08
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Protein array profiling of circulating angiogenesis-related factors during bevacizumab containing treatment in metastatic colorectal cancer
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PLoS ONE, 2018-12-28;13(12):e0209838. 2018-12-28
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Mitochondrial dysfunction is a key determinant of the rare disease lymphangioleiomyomatosis and provides a novel therapeutic target
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Oncogene, 2018-12-20;0(0):. 2018-12-20
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Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells
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Front Pharmacol, 2018-12-10;9(0):1455. 2018-12-10
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Homotypic and Heterotypic Activation of the Notch Pathway in Multiple Myeloma-Enhanced Angiogenesis: A Novel Therapeutic Target?
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Neoplasia, 2018-12-05;21(1):93-105. 2018-12-05
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A Subset of Paracrine Factors as Efficient Biomarkers for Predicting Vascular Regenerative Efficacy of Mesenchymal Stromal/Stem Cells
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Stem Cells, 2018-10-08;0(0):. 2018-10-08
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Nintedanib inhibits growth of human prostate carcinoma cells by modulating both cell cycle and angiogenesis regulators
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Sci Rep, 2018-06-22;8(1):9540. 2018-06-22
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Intranasal delivery of VEGF enhances compensatory lung growth in mice
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PLoS ONE, 2018-06-07;13(6):e0198700. 2018-06-07
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Increased platelet factor 4 and aberrant permeability of follicular fluid in PCOS
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J. Formos. Med. Assoc., 2018-05-18;0(0):. 2018-05-18
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Extracellular Matrix composition modulates PDAC parenchymal and stem cell plasticity and behavior through the secretome
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FEBS J., 2018-04-27;0(0):. 2018-04-27
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Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions
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Arterioscler. Thromb. Vasc. Biol., 2018-03-29;0(0):. 2018-03-29
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Human dental pulp stromal cell conditioned medium alters endothelial cell behavior
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Stem Cell Res Ther, 2018-03-21;9(1):69. 2018-03-21
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Multipotent Adult Progenitor Cells Support Lymphatic Regeneration at Multiple Anatomical Levels during Wound Healing and Lymphedema
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Sci Rep, 2018-03-01;8(1):3852. 2018-03-01
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hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis
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Transl Psychiatry, 2018-02-22;8(1):48. 2018-02-22
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Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide
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Nucleic Acids Res., 2018-02-16;0(0):. 2018-02-16
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Plocabulin, a novel tubulin-binding agent, inhibits angiogenesis by modulation of microtubule dynamics in endothelial cells
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BMC Cancer, 2018-02-07;18(1):164. 2018-02-07
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Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin� protein MP0250: a preclinical study
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Oncotarget, 2018-01-30;9(17):13366-13381. 2018-01-30
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Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379
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Oncogene, 2018-01-25;0(0):. 2018-01-25
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Stimulation of Interferon-Stimulated Gene 20 by Thyroid Hormone Enhances Angiogenesis in Liver Cancer
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Neoplasia, 2017-11-29;20(1):57-68. 2017-11-29
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Neuroprotective Effects of Human Mesenchymal Stem Cells and Platelet-Derived Growth Factor on Human Retinal Ganglion Cells
Authors: A Osborne, J Sanderson, KR Martin
Stem Cells, 2017-10-31;0(0):. 2017-10-31
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Combination curcumin and (-)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway
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Oncogenesis, 2017-10-02;6(10):e384. 2017-10-02
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Metabolically conditioned media derived from bone marrow stromal cells or human skin fibroblasts act as effective chemoattractants for mesenchymal stem cells
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Stem Cell Res Ther, 2017-09-29;8(1):212. 2017-09-29
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Sonic hedgehog (SHH) signaling improves the angiogenic potential of Wharton's jelly-derived mesenchymal stem cells�(WJ-MSC)
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Stem Cell Res Ther, 2017-09-29;8(1):203. 2017-09-29
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Therapeutic potential of an anti-angiogenic multimodal biomimetic peptide in hepatocellular carcinoma
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Oncotarget, 2017-09-21;8(60):101520-101534. 2017-09-21
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SCO-spondin oligopeptide inhibits angiogenesis in glioblastoma
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Oncotarget, 2017-09-12;8(49):85969-85983. 2017-09-12
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Cell Spheroids with Enhanced Aggressiveness to Mimic Human Liver Cancer In Vitro and In Vivo
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Sci Rep, 2017-09-05;7(1):10499. 2017-09-05
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Cell. Signal., 2017-07-28;39(0):44-54. 2017-07-28
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Cancer Res., 2017-07-28;0(0):. 2017-07-28
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Methyltransferase G9a promotes cervical cancer angiogenesis and decreases patient survival
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Oncotarget, 2017-07-07;8(37):62081-62098. 2017-07-07
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Human adipose-derived mesenchymal stem cell-secreted CXCL1 and CXCL8 facilitate breast tumor growth by promoting angiogenesis
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Stem Cells, 2017-06-05;0(0):. 2017-06-05
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CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect
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JCI Insight, 2017-01-26;2(2):e89906. 2017-01-26
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Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism
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J Hematol Oncol, 2017-01-18;10(1):19. 2017-01-18
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NF-?B Signaling Activation Induced by Chloroquine Requires Autophagosome, p62 Protein, and c-Jun N-terminal Kinase (JNK) Signaling and Promotes Tumor Cell Resistance
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Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
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Autophagy, 2017-01-01;0(0):0. 2017-01-01
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The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts
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Identification of neuronal and angiogenic growth factors in an in vitroblood-brain barrier model system: Relevance in barrier integrity and tight junction formation and complexity
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Microvasc. Res, 2016-12-15;0(0):. 2016-12-15
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Synergic effects of VEGF-A and SDF-1 on the angiogenic properties of endothelial progenitor cells
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VLDL and LDL, but not HDL, promote breast cancer cell proliferation, metastasis and angiogenesis
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Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor
Stem Cell Res Ther, 2016-11-29;7(1):173. 2016-11-29
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Ethanol extract of Lophatheri Herba exhibits anti-cancer activity in human cancer cells by suppression of metastatic and angiogenic potential
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Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment
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The Development of an Angiogenic Protein Signature in Ovarian Cancer Ascites as a Tool for Biologic and Prognostic Profiling
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PLoS ONE, 2016-06-03;11(6):e0156403. 2016-06-03
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IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
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Prostacyclin-producing human mesenchymal cells target H19 lncRNA to augment endogenous progenitor function in hindlimb ischaemia
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Identification of Novel Biomarkers for Metastatic Colorectal Cancer Using Angiogenesis-Antibody Array and Intracellular Signaling Array.
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Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?
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Intratumoral CD14+ Cells and Circulating CD14+HLA-DRlo/neg Monocytes Correlate with Decreased Survival in Patients with Clear Cell Renal Cell Carcinoma.
Authors: Gustafson M, Lin Y, Bleeker J, Warad D, Tollefson M, Crispen P, Bulur P, Harrington S, Laborde R, Gastineau D, Leibovich B, Cheville J, Kwon E, Dietz A
Clin Cancer Res, 2015-05-21;21(18):4224-33. 2015-05-21
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CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.
Authors: Mazumdar, Sohini, Arendt, Lisa M, Phillips, Sarah, Sedic, Maja, Kuperwasser, Charlott, Gill, Grace
PLoS ONE, 2015-03-20;10(3):e0121281. 2015-03-20
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Deficiency of endothelium-specific transcription factor Sox17 induces intracranial aneurysm.
Authors: Lee S, Kim I, Ahn J, Woo D, Kim S, Song S, Koh G, Kim H, Jeon B, Kim I
2015-01-16;0(0):. 2015-01-16
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Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells.
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Stem Cells Dev, 2014-12-22;24(7):869-78. 2014-12-22
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Sourcing of an alternative pericyte-like cell type from peripheral blood in clinically relevant numbers for therapeutic angiogenic applications.
Authors: Blocki A, Wang Y, Koch M, Goralczyk A, Beyer S, Agarwal N, Lee M, Moonshi S, Dewavrin J, Peh P, Schwarz H, Bhakoo K, Raghunath M
Mol Ther, 2014-12-12;23(3):510-22. 2014-12-12
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Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model.
Authors: Bussche L, Van de Walle G
Stem Cells Transl Med, 2014-10-13;3(12):1514-25. 2014-10-13
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Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis.
Authors: Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A
Nat Commun, 2014-09-02;5(0):4715. 2014-09-02
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Lymphatic endothelial cells support tumor growth in breast cancer.
Authors: Lee, Esak, Pandey, Niranjan, Popel, Aleksand
Sci Rep, 2014-07-28;4(0):5853. 2014-07-28
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Ionizing radiation induces tumor cell lysyl oxidase secretion.
Authors: Shen C, Sharma A, Vuong D, Erler J, Pruschy M, Broggini-Tenzer A
BMC Cancer, 2014-07-22;14(0):532. 2014-07-22
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Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.
Authors: Wilson C, Naves T, Vincent F, Melloni B, Bonnaud F, Lalloue F, Jauberteau M
J Cell Sci, 2014-07-18;127(0):3983-97. 2014-07-18
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RECK controls breast cancer metastasis by modulating a convergent, STAT3-dependent neoangiogenic switch.
Authors: Walsh, L A, Roy, D M, Reyngold, M, Giri, D, Snyder, A, Turcan, S, Badwe, C R, Lyman, J, Bromberg, J, King, T A, Chan, T A
Oncogene, 2014-06-16;34(17):2189-203. 2014-06-16
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Lysophosphatidic acid enhanced the angiogenic capability of human chondrocytes by regulating Gi/NF-kB-dependent angiogenic factor expression.
Authors: Chuang, Yi-Wen, Chang, Wen-Ming, Chen, Kai-Hua, Hong, Chang-Ze, Chang, Pey-Jium, Hsu, Hung-Chi
PLoS ONE, 2014-05-30;9(5):e95180. 2014-05-30
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Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells.
Authors: Ruma I, Putranto E, Kondo E, Watanabe R, Saito K, Inoue Y, Yamamoto K, Nakata S, Kaihata M, Murata H, Sakaguchi M
Int J Oncol, 2014-04-24;45(1):209-18. 2014-04-24
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Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFbeta signaling.
Authors: Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson C, Mukhopadhyay N, Fisher P, Sarkar D
FEBS Open Bio, 2014-04-01;4(0):353-61. 2014-04-01
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Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin.
Authors: Hutzen, Brian, Bid, Hemant K, Houghton, Peter J, Pierson, Christop, Powell, Kimerly, Bratasz, Anna, Raffel, Corey, Studebaker, Adam W
BMC Cancer, 2014-03-19;14(0):206. 2014-03-19
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Surgical sutures filled with adipose-derived stem cells promote wound healing.
Authors: Reckhenrich A, Kirsch B, Wahl E, Schenck T, Rezaeian F, Harder Y, Foehr P, Machens H, Egana J
PLoS ONE, 2014-03-13;9(3):e91169. 2014-03-13
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Histone deacetylase-3 mediates positive feedback relationship between anaphylaxis and tumor metastasis.
Authors: Eom S, Kim Y, Park D, Lee H, Lee Y, Choe J, Kim Y, Jeoung D
J Biol Chem, 2014-03-11;289(17):12126-44. 2014-03-11
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Mesenchymal stromal cells: inhibiting PDGF receptors or depleting fibronectin induces mesodermal progenitors with endothelial potential.
Authors: Ball S, Worthington J, Canfield A, Merry C, Kielty C
Stem Cells, 2014-03-01;32(3):694-705. 2014-03-01
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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
Authors: Wojciak-Stothard B, Abdul-Salam V, Lao K, Tsang H, Irwin D, Lisk C, Loomis Z, Stenmark K, Edwards J, Yuspa S, Howard L, Edwards R, Rhodes C, Gibbs J, Wharton J, Zhao L, Wilkins M
Circulation, 2014-02-06;129(17):1770-80. 2014-02-06
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Fibroblasts derived from human pluripotent stem cells activate angiogenic responses in vitro and in vivo.
Authors: Shamis Y, Silva E, Hewitt K, Brudno Y, Levenberg S, Mooney D, Garlick J
PLoS ONE, 2013-12-30;8(12):e83755. 2013-12-30
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PTEN expression is involved in the invasive properties of HNSCC: a key protein to consider in locoregional recurrence.
Authors: Mriouah J, Boura C, Gargouri M, Plenat F, Faivre B
Int J Oncol, 2013-12-19;44(3):709-16. 2013-12-19
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A metabolic shift favoring sphingosine 1-phosphate at the expense of ceramide controls glioblastoma angiogenesis.
Authors: Abuhusain, Hazem J, Matin, Azadeh, Qiao, Qiao, Shen, Han, Kain, Nupur, Day, Bryan W, Stringer, Brett W, Daniels, Benjamin, Laaksonen, Maarit A, Teo, Charlie, McDonald, Kerrie L, Don, Anthony
J Biol Chem, 2013-11-21;288(52):37355-64. 2013-11-21
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Angiogenesis stimulated by human kallikrein-related peptidase 12 acting via a platelet-derived growth factor B-dependent paracrine pathway.
Authors: Kryza T, Achard C, Parent C, Marchand-Adam S, Guillon-Munos A, Iochmann S, Korkmaz B, Respaud R, Courty Y, Heuze-Vourc'h N
FASEB J, 2013-11-13;28(2):740-51. 2013-11-13
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Functional and molecular characterization of ex vivo cultured epiretinal membrane cells from human proliferative diabetic retinopathy.
Authors: Vereb Z, Lumi X, Andjelic S, Globocnik-Petrovic M, Urbancic M, Hawlina M, Facsko A, Petrovski G
Biomed Res Int, 2013-10-01;2013(0):492376. 2013-10-01
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A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma.
Authors: Box C, Mendiola M, Gowan S, Box G, Valenti M, Brandon A, Al-Lazikani B, Rogers S, Wilkins A, Harrington K, Eccles S
Eur J Cancer, 2013-04-10;49(0):2512-21. 2013-04-10
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Inhibition of TGF-β signaling by the fungal lactones (S)-curvularin, dehydrocurvularin, oxacyclododecindione and galiellalactone.
Cytokine, 2012-11-05;61(1):285-96. 2012-11-05
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Age-related changes in expression and function of Toll-like receptors in human skin.
Authors: Iram N, Mildner M, Prior M, Petzelbauer P, Fiala C, Hacker S, Schoppl A, Tschachler E, Elbe-Burger A
Development, 2012-10-03;139(22):4210-9. 2012-10-03
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Tumor-initiating cells of various tumor types exhibit differential angiogenic properties and react differently to antiangiogenic drugs.
Authors: Benayoun L, Gingis-Velitski S, Voloshin T, Segal E, Segev R, Munster M, Bril R, Satchi-Fainaro R, Scherer S, Shaked Y
Stem Cells, 2012-09-01;30(9):1831-41. 2012-09-01
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Ultraviolet B preconditioning enhances the hair growth-promoting effects of adipose-derived stem cells via generation of reactive oxygen species.
Stem Cells Dev, 2012-08-13;22(1):158-68. 2012-08-13
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Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.
Authors: Porter, Donald C, Farmaki, Elena, Altilia, Serena, Schools, Gary P, West, Deborah, Chen, Mengqian, Chang, Bey-Dih, Puzyrev, Anatoliy, Lim, Chang-uk, Rokow-Kittell, Rebecca, Friedhoff, Lawrence, Papavassiliou, Athanasi, Kalurupalle, Swathi, Hurteau, Gregory, Shi, Jun, Baran, Phil S, Gyorffy, Balazs, Wentland, Mark P, Broude, Eugenia, Kiaris, Hippokra, Roninson, Igor B
Proc Natl Acad Sci U S A, 2012-08-06;109(34):13799-804. 2012-08-06
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Met Receptor Tyrosine Kinase Signaling Induces Secretion of the Angiogenic Chemokine Interleukin-8/CXCL8 in Pancreatic Cancer.
Authors: Hill KS, Gaziova I, Harrigal L
PLoS ONE, 2012-07-17;7(7):e40420. 2012-07-17
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Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway.
EMBO J., 2012-07-06;31(17):3513-23. 2012-07-06
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Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche.
Authors: Sceneay J, Chow M, Chen A, Halse H, Wong C, Andrews D, Sloan E, Parker B, Bowtell D, Smyth M, Moller A
Cancer Res, 2012-07-02;72(16):3906-11. 2012-07-02
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Differentiation state determines neural effects on microvascular endothelial cells.
Authors: Muffley L, Pan S, Smith A, Ga M, Hocking A, Gibran N
Exp Cell Res, 2012-06-07;318(16):2085-93. 2012-06-07
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Highly invasive melanoma cells activate the vascular endothelium via an MMP-2/integrin alphavbeta5-induced secretion of VEGF-A.
Am. J. Pathol., 2012-05-31;181(2):693-705. 2012-05-31
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Multifunction protein staphylococcal nuclease domain containing 1 (SND1) promotes tumor angiogenesis in human hepatocellular carcinoma through novel pathway that involves nuclear factor κB and miR-221.
Authors: Santhekadur PK, Das SK, Gredler R, Chen D, Srivastava J, Robertson C, Baldwin AS, Fisher PB, Sarkar D
J. Biol. Chem., 2012-03-06;287(17):13952-8. 2012-03-06
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The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells.
Authors: Rittig K, Dolderer JH, Balletshofer B, Machann J, Schick F, Meile T, Kuper M, Stock UA, Staiger H, Machicao F, Schaller HE, Konigsrainer A, Haring HU, Siegel-Axel DI
Diabetologia, 2012-02-13;55(5):1514-25. 2012-02-13
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Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9).
Authors: Santhekadur PK, Gredler R, Chen D
J. Biol. Chem., 2011-12-13;287(5):3425-32. 2011-12-13
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Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior.
Authors: Heinke J, Kerber M, Rahner S
Oncogene, 2011-10-24;31(24):2919-30. 2011-10-24
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Human amniotic fluid-derived mesenchymal stem cells as therapeutic vehicles: a novel approach for the treatment of bladder cancer.
Authors: Bitsika V, Roubelakis MG, Zagoura D, Trohatou O, Makridakis M, Pappa KI, Marini FC, Vlahou A, Anagnou NP
Stem Cells Dev., 2011-10-11;21(7):1097-111. 2011-10-11
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Protein profiling of angiogenesis-related growth factors in laryngeal carcinoma: Pattern of protein expression in relation to tumour progression.
Authors: Korampalli TS, Green VL, Greenman J
Int. J. Oncol., 2011-07-08;39(4):1033-9. 2011-07-08
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LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma.
Authors: Dormoy V, Beraud C, Lindner V, Thomas L, Coquard C, Barthelmebs M, Jacqmin D, Lang H, Massfelder T
Oncogene, 2010-12-06;30(15):1753-63. 2010-12-06
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Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms.
Authors: Kachgal S, Putnam AJ
Angiogenesis, 2010-11-21;14(1):47-59. 2010-11-21
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Involvement of autocrine CXCL12/CXCR4 system in the regulation of ovarian carcinoma cell invasion.
Authors: Miyanishi N, Suzuki Y, Simizu S, Kuwabara Y, Banno K, Umezawa K
Biochem. Biophys. Res. Commun., 2010-11-06;403(1):154-9. 2010-11-06
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Syndecan-1 knock-down in decidualized human endometrial stromal cells leads to significant changes in cytokine and angiogenic factor expression patterns.
Authors: Baston-Bust DM, Gotte M, Janni W, Krussel JS, Hess AP
Reprod. Biol. Endocrinol., 2010-11-02;8(0):133. 2010-11-02
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Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis.
Authors: Bordoli MR, Stiehl DP, Borsig L, Kristiansen G, Hausladen S, Schraml P, Wenger RH, Camenisch G
Oncogene, 2010-09-20;30(5):548-60. 2010-09-20
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MBP-1 inhibits breast cancer growth and metastasis in immunocompetent mice.
Authors: Kanda T, Raychoudhuri A, Steele R, Sagartz JE, West C, Ray RB
Cancer Res., 2009-12-15;69(0):9354-9. 2009-12-15
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p53-mediated inhibition of angiogenesis in diffuse low-grade astrocytomas.
Authors: Gaiser T, Becker MR, Meyer J
Neurochem. Int., 2009-02-06;54(7):458-63. 2009-02-06
FAQs
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Will the Array identification number stamped on the Array membrane interfere with detection if it is not cut-off before the membrane is blocked?
The dye used for printing the Array identification number on the membranes will fluoresce and interfere with the LI-COR detection. It is critical that the number is cut off before beginning the experiment.
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What are the associated pathways each factor is involved in?
We do not have specific angiogenesis-related categorization of the target for this array, but we do have some informative material available in our website:
- https://www.rndsystems.com/research-area/angiogenesis
- https://www.novusbio.com/research-areas/cancer/angiogenesis
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Could you tell us whether this MMP-9 antibody can detect TIMP and MMP-9 complex?
We haven't performed a large amount of specificity testing per each spot in the arrays because these are qualitative screening tools. However, we would recommend treating the MMP-9 spot as a "Total MMP-9" detecting both free MMP-9 and MMP-9 in complex. If the MMP-9 spot turns out to be of high interest for the customer's study, they will want to examine this target in more detail with quantitative tools such as ELISA or Luminex.
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Which gene of the VEGF family is detected on E19 and E20
The VEGF spots are detecting VEGF-A.
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Does the Human Angiogenesis Proteome Profiler Array cross-react with other species like equines?
We have not tested this kit with equine samples. However, when looking at the cross reactivity with our Proteome Profiler Arrays, there are a few things to keep in mind. When the arrays are being designed, we look for the best antibodies that will work for the species stated. This does not mean there will not be any cross reactivity between species but it does suggest that the assay would not perform equally between species. While it is possible that some of the antibodies may detect the equine protein, different antibodies cross-react at different levels.
It is also important to note that the Proteome Profiler Arrays are designed to be used as a screening tool. This may be a good place to start if you are trying determine what may be having an increase or a decrease in signal. We recommend running one untreated sample and comparing them to your treated samples. Even though you may not have the exact same cross reactivity with each analyte, you may be able to detect the increase or decrease from your samples.
We have searched for citations that may have referenced using this kit with equine samples and were able to find 1. Here is the link to it: https://www.ncbi.nlm.nih.gov/pubmed/25313202.
Reviews for Proteome Profiler Human Angiogenesis Array Kit
Average Rating: 4.9 (Based on 10 Reviews)
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We ordered the Angiogenesis Array Kit for both mice and humans, and it is highly sensitive for both solid tumor and serum samples.
HepG2 lysate concentrated, DMEM FBS free, 300 ug loaded.
Worked well to look at THP-1 angiogenesis factors.
It worked well in cell culture supernatants using 125 ug of total protein per membrane.
Used it on Conditioned medium collected from Breast Cancer Cells treated with Angiotensin II to look into its effect on Angiogenesis. Angiogenesis array worked really well and very easy to use. It provided some new promising gene targets which we did not know before.
Human Angiogenesis Antibody Array was used to evaluate mesenchymal stem cells secretion profiles when seeded in various extracellular matrices. Great tool that ganarates lots of data!